[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544924":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":40,"centralContacts":45,"locations":55,"responsibleParty":74,"collaborators":77,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":10,"enrollmentInfo":91,"targetDuration":94,"studyType":95,"phases":10,"briefSummary":96,"conditions":97,"keywords":10,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"King Chulalongkorn Memorial Hospital","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitively healthy",null,"This cohort includes participants with or without subjective complaints whose results of cognitive examination are normal. Participants will undergo clinical, epidemiological, and cognitive assessments, as well as biospecimen collection every two years, over an 8-year follow-up period.",[13,14],"Diagnostic Test: Plasma tau phosphorylated at Thr217","Other: Neurocognitive examination",{"label":16,"type":10,"description":17,"interventionNames":18},"Mild cognitive impairment","This cohort includes participants whose results of cognitive examination are abnormal but have not met the criteria for dementia. Participants will undergo annual clinical, epidemiological, and cognitive assessments, as well as biospecimen collection, for a duration of six years.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Late onset dementia","This cohort includes participants with dementia whose symptoms onset after the age of 65. Participants will undergo annual clinical, epidemiological, and cognitive assessments, as well as biospecimen collection, for a duration of two years.",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Early onset dementia","This cohort includes participants with dementia whose symptoms onset before the age of 65. Participants will undergo annual clinical, epidemiological, and cognitive assessments, as well as biospecimen collection, for a duration of six years.",[13,14],[28,36],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DIAGNOSTIC_TEST","Plasma tau phosphorylated at Thr217","Plasma concentration of tau protein phosphorylated at Thr217 as measured on the Meso Scale Discovery, single molecule array (Simoa) or the in-house mass spectrometry platform.",[9,24,20,16],[34,35],"S-PLEX Human Tau (pT217) Kit","ALZpath pTau-217 CARe Advantage Kit",{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"Neurocognitive examination","Traditional (paper and pencil) neurocognitive\u002Fneuropsychiatric examination performed by certified psychologists. This includes: Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating (CDR), Wechsler Memory Scale - Fourth Edition (WMS-IV), Neuropsychiatric Inventory - Questionnaire (NPI-Q), Thai Geriatric Depression Scale (TGDS), General Anxiety Disorder - 7 (GAD-7), The Barthel activities of daily living (ADL) Index, Chula ADL Index.",[9,24,20,16],[41],{"name":42,"affiliation":43,"role":44},"Thiravat Hemachudha, M.D.","Chulalongkorn University","PRINCIPAL_INVESTIGATOR",[46,52],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Poosanu Thanapornsangsuth, M.D.","CONTACT","+66 (0)2 2564000","3561","poosanu.t@chula.ac.th",{"name":53,"role":48,"phone":10,"phoneExt":10,"email":54},"Thanakit Pongpitakmetha, M.D.","thanakit.p@chula.ac.th",[56],{"facility":5,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"RECRUITING","Pathum Wan","Bangkok","10330","Thailand","TH",{"type":64,"coordinates":65},"Point",[66,67],100.52329,13.73698,{"lat":67,"lon":66},[70],{"name":71,"role":48,"phone":72,"phoneExt":10,"email":73},"Adipa Chongsuksantikul, D.Eng.","+66 (0)84 1134443","adipar@gmail.com",{"type":44,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Poosanu Thanapornsangsuth","Doctor",[78],{"name":79,"class":80},"Health Systems Research Institute,Thailand","OTHER_GOV","100544924","investigating-neurocognitive-disorders-epidemiology-100544924",false,"NCT06375213","Investigating Neurocognitive Disorders Epidemiology","INDE","1. Cognitively Healthy Individuals\n\n   INCLUSION CRITERIA\n   * Demonstrate normal cognitive function within the expected range on objective cognitive tests.\n   * Proficient in speaking and understanding Thai without the need for a translator to participate.\n\n   EXCLUSION CRITERIA\n   * Significant neurological or uncontrolled psychiatric illness.\n   * Significant unstable systemic condition or end-stage organ failure that affects study participation.\n2. Mild Cognitive Impairment\n\n   INCLUSION CRITERIA\n   * Display impaired\u002Fabnormal performance on objective cognitive tests.\n   * Does not meet criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5).\n   * Proficient in speaking and understanding Thai without the need for a translator to participate.\n\n   EXCLUSION CRITERIA\n   * Significant neurological or uncontrolled psychiatric illness.\n   * Significant unstable systemic condition or end-stage organ failure that affects study participation.\n3. Late Onset Dementia\n\n   INCLUSION CRITERIA\n   * Display impaired\u002Fabnormal performance on objective cognitive tests.\n   * Meets criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5), including dementia due to Alzheimer's disease or other causes.\n   * Begins to experience symptoms, identified by the physician as a part of dementia continuum, occurring after the age of 65.\n   * Proficient in speaking and understanding Thai without the need for a translator to participate.\n\n   EXCLUSION CRITERIA\n   * Significant neurological or uncontrolled psychiatric illness.\n   * Significant unstable systemic condition or end-stage organ failure that affects study participation.\n4. Early Onset Dementia\n\nINCLUSION CRITERIA\n\n* Display impaired\u002Fabnormal performance on objective cognitive tests.\n* Meets criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5), including dementia due to Alzheimer's disease or other causes.\n* Begins to experience symptoms, identified by the physician as a part of dementia continuum, occurring before the age of 65.\n* Proficient in speaking and understanding Thai without the need for a translator to participate.\n\nEXCLUSION CRITERIA\n\n* Significant neurological or uncontrolled psychiatric illness.\n* Significant unstable systemic condition or end-stage organ failure that affects study participation.",true,"ALL","35 Years",{"count":92,"type":93},990,"ESTIMATED","8 Years","OBSERVATIONAL","This is a prospective cohort study with the main purpose of predicting progression neurocognitive disorders in Thai population. The main predictor variables to be evaluated are plasma phosphorylated tau (p-tau) level and cognitive test scores, which will be combined using statistical\u002Fcomputational modeling. Additionally, it seeks to evaluate biomarkers for diagnosing disease pathologies, understand their correlation with clinical outcomes, and explore the socioeconomic impact of neurocognitive disorders. The study invites both participants for biospecimen collection, structured interviews, and cognitive examinations and schedules follow-up visits annually or biennially.",[98,99,100],"Dementia","Cognitive Decline","Alzheimer Disease","2024-04-18",{"date":103,"type":104},"2024-04-22","ACTUAL",{"date":106,"type":104},"2023-08-24",{"date":108,"type":93},"2035-08-24",{"name":5,"class":6},1]