[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100373374":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":62,"collaborators":64,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":10,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":10,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",[8,12,17],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy Control",null,"non-obese individuals without fatty liver disease",{"label":13,"type":10,"description":14,"interventionNames":15},"Obese wihtout non-alcoholic steatohepatitis","Body mass index greater than 30 without liver histological evidence of non-alcoholic fatty liver disease",[16],"Procedure: Bariatric Surgery",{"label":18,"type":10,"description":19,"interventionNames":20},"Obese Non-alcoholic steatohepatitis","Body mass index greater than 30 with liver histological evidence of non-alcoholic fatty liver disease",[16],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Bariatric Surgery","Already clinically indicated surgical procedures",[18,13],[28],"Upper GI surgery",[30],{"name":31,"affiliation":5,"role":32},"William Alazawi, MD Phd","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","+442078822308","w.alazawi@qmul.ac.uk",{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},"James Brindley, Md Phd","+442078827198","james.brindley@nhs.net",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Homerton University Hospital Foundation Trust","RECRUITING","London","Greater London","E9 6SR","United Kingdom","UK",{"type":52,"coordinates":53},"Point",[54,55],-0.12574,51.50853,{"lat":55,"lon":54},[58],{"name":59,"role":35,"phone":60,"phoneExt":10,"email":61},"Rosemary Mullett","+44208 510 5117","rosemary.mullett@nhs.net",{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[65,67,69],{"name":66,"class":6},"Homerton University Hospital NHS Foundation Trust",{"name":68,"class":6},"Barts & The London NHS Trust",{"name":70,"class":6},"King's College Hospital NHS Trust","100373374","investigating-pathological-mechanisms-in-non-alcoholic-fatty-liver-disease-100373374",false,"NCT04141592","Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease","Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease: Cross-sectional Comparative Study Between Patients and Healthy Controls","Inclusion Criteria:\n\n* Age ≥18 years\n* Confirmed non-alcoholic Fatty liver disease (diagnosed clinically, radiologically or histologically)\n* If diabetic, Diagnosed with Type 2 Diabetes Mellitus\n\nOR\n\n• Healthy Control: no diagnosis of any liver condition including NAFLD\n\no NAFLD excluded by Fibroscan Controlled Attenuation Parameter (CAP) score of \\\u003C222 dB\u002Fm\n\nExclusion Criteria:\n\n* Unwilling or unable to give informed consent\n* Type 1 Diabetes Mellitus\n* Other form of liver disease (other than NAFLD)\n\n  o Viral hepatitis, Auto-immune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis, haemochromatosis, Sarcoidosis, cystic fibrosis, sickle cell disease\n* Taking medication associated with liver dysfunction (except methotrexate)\n* Auto-immune disease which in the investigator's opinion may confound immune profiling\n* Concomitant immunosuppressive medications (except methotrexate, short course oral steroids or inhaled corticosteroids)\n* Currently pregnant\n* Any major organ transplant (excluding corneal or hair transplant)\n* Regular alcohol intake greater than 14 units a week for female participants and 21 units a week for male participants","ALL","18 Years",{"count":81,"type":82},153,"ESTIMATED","OBSERVATIONAL","To identify key characteristics of the tissue resident and peripherally circulating immune-phenotype in addition to blood markers, metabolic profile, faecal and oral microbiota in non-alcoholic fatty liver disease",[86],"Non-Alcoholic Fatty Liver Disease","2026-06-03",{"date":89,"type":90},"2026-06-05","ACTUAL",{"date":92,"type":90},"2019-03-05",{"date":94,"type":82},"2026-07-31",{"name":5,"class":6},1]