[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609005":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":24,"locations":30,"responsibleParty":43,"collaborators":11,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":11,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":11,"overallStatus":65,"whyStopped":11,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Assistance Publique Hopitaux De Marseille","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with Adolescent Idiopathic Scoliosis","EXPERIMENTAL",null,[13],"Radiation: MRI",{"label":15,"type":16,"description":17,"interventionNames":11},"Healthy subjects","NO_INTERVENTION","External control arm of 30 healthy volounteers from the Human Connectome project from where MRI images will be retrieved.",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"RADIATION","MRI","Brain and Spinal Cord MRI",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},"KAVOUNOUDIAS","CONTACT","+33(0)4 13 55 08 42","anne.kavounoudias@univ-amu.fr",[31],{"facility":32,"status":11,"city":33,"state":11,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":11},"Assistance Publique Hôpitaux de Marseille","Marseille","13354","France","FR",{"type":38,"coordinates":39},"Point",[40,41],5.38107,43.29695,{"lat":41,"lon":40},{"type":44,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100609005","investigating-proprioceptive-impairment-in-adolescents-with-idiopathic-scoliosis-ais-scolio-proprio-100609005",false,"NCT07208929","Investigating Proprioceptive Impairment in Adolescents With Idiopathic Scoliosis (AIS) (SCOLIO-PROPRIO)","Investigating Proprioceptive Impairment in Adolescents With Idiopathic Scoliosis (AIS)","SCOLIO-PROPRIO","Inclusion Criteria:\n\n* Adolescents diagnosed with Adolescent Idiopathic Scoliosis (AIS) and followed in the pediatric orthopedic surgery department, scheduled to undergo spinal fusion surgery (arthrodesis)\n* No history or clinical signs of neurological disorders\n* Aged between 10 and 18 years\n* Written informed consent obtained from both the adolescent and their legal guardians (parents)\n* Control Group only: Participants will be selected from open-access neuroimaging databases, matched to the patient group by age and sex.\n\nExclusion Criteria:\n\n* Presence of any other clinically significant condition that could be associated with spinal deformity\n* Insufficient proficiency in French to understand the informed consent form\n* Current treatment with psychotropic medication\n* Ongoing pregnancy or breastfeeding\n* Subject under legal or judicial supervision\n* Contraindications to brain MRI (including: pacemaker; electrically, magnetically, or mechanically activated implants; surgical clips; metallic sutures; staples; etc. - see MRI safety questionnaire annex)\n* Subject or their parent(s)\u002Flegal guardian(s) refuse to be informed of incidental findings detected during MRI\n* Claustrophobia","ALL","10 Years","18 Years",{"count":57,"type":58},60,"ESTIMATED","INTERVENTIONAL",[61],"NA","The goal of this interventionnal study is to learn if teenagers who have severe scoliosis (a curvature of the spine) have trouble sensing their body's position in space (this sense is called proprioception), which are directly linked to abnormalities in the part of the brain that controls movement and\u002For caused by the muscles on each side of the spine not being the same size or not developing in the same way.\n\nThe main question the investigators aim to answer are :\n\n* Do adolescents with severe scoliosis have problems with their sense of body position (proprioception)?\n* If so, are these proprioceptive issues linked to specific problems in the part of the brain that controls movement?\n* Are these proprioceptive issues also possibly linked to an uneven muscle structure on either side of the spinal curve?\n\nResearchers will compare the part of the brain that controls movement (ensorimotor brain network) of healthy subjects to that of the participants that will enroll in this study.\n\nParticipants will only have to do one more MRI that is not included in the routine of clinical management of scoliosis before surgery.\n\nData will also be retrieved from clinical practice Participants will answer questionnaires after the day of the surgery",[64],"Scoliosis Idiopathic Adolescent","NOT_YET_RECRUITING","2025-09-29",{"date":68,"type":69},"2025-10-06","ACTUAL",{"date":71,"type":58},"2025-10",{"date":73,"type":58},"2027-12",{"name":5,"class":6},1]