[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592310":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":31,"centralContacts":36,"locations":30,"responsibleParty":45,"collaborators":48,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":30,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":30,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":82,"whyStopped":30,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":30},{"fullName":5,"class":6},"Nanyang Technological University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Transcranial Direct Current Stimulation (tDCS)","ACTIVE_COMPARATOR","In this condition, current intensity will be maintained between 0.6 to 0.7 mA for 20 minutes.",[13],"Device: Non-Invasive Brain Stimulation (tDCS \u002F tPCS \u002F sham-tPCS)",{"label":15,"type":16,"description":17,"interventionNames":18},"High Frequency Transcranial Pulsed Current Stimulation (HF-tPCS)","EXPERIMENTAL","In this condition, current will be introduced in pulses with intensity consistent between 0.6 to 0.7 mA. The duration of the stimulation is 20 minutes.",[13],{"label":20,"type":21,"description":22,"interventionNames":23},"Sham-tPCS","SHAM_COMPARATOR","In this condition, there will be a 30 seconds ramp-up phase to a current intensity between 0.6 to 0.7 mA followed by a 30 seconds ramp-down phase to 0 mA. The participant will, however, remain seated with the set-up for the remaining time until 20 minutes is up.",[13],[25],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Non-Invasive Brain Stimulation (tDCS \u002F tPCS \u002F sham-tPCS)","This is a novel non-invasive brain stimulation technique that we hope to be investigating, and this technique will be compared with an active control (tDCS) and a control (sham-tPCS).",[15,20,9],null,[32],{"name":33,"affiliation":34,"role":35},"Wei Peng Teo, Associate Professor","National Institute of Education, Nanyang Technological University, Singapore","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":30,"email":40},"CONTACT","(+65)67903704","weipeng.teo@nie.edu.sg",{"name":42,"role":38,"phone":43,"phoneExt":30,"email":44},"Shun Xin Koong","(+65)83078316","nie25.ksx@e.ntu.edu.sg",{"type":35,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Teo Wei Peng","Associate Professor",[49,52],{"name":50,"class":51},"Ministry of Education, Singapore","OTHER_GOV",{"name":53,"class":6},"National Institute of Education, Singapore","100592310","investigating-the-effectiveness-of-a-2-week-novel-non-invasive-brain-stimulation-technique-on-cognitive-outcomes-in-healthy-adults-100592310",false,"NCT06991764","Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults","Investigating the Effectiveness of a 2-week High-frequency Transcranial Pulsed-current Stimulation on Cognitive Outcomes in Healthy Adults: A Randomised, Double Blinded, Sham-controlled Study","Inclusion Criteria:\n\n* Male and female young (21 to 30 years) and older adults (60 to 75 years)\n* Right-handed\n* Must be a native English speaker\n* No clinical diagnosis of neurodevelopmental, mood, neurological or neurodegenerative disorders\n* Adults with cardiometabolic or cardiovascular conditions may participate if their condition is controlled and stable with medication and \u002F or lifestyle interventions\n\nExclusion Criteria:\n\n* Currently on long-term medication for pain or migraines \u002F headaches\n* Adults with metallic implants in the chest or head region\n* Adults with epilepsy, or known seizure or immediate family members that have had a seizure before\n* Had a recent head injury that resulted in a temporary loss of consciousness or of memory in the last 12 months\n* Had prior head surgery\n* Prone to fainting\n* Sensitive skin or prone to skin allergies",true,"ALL","21 Years","75 Years",{"count":66,"type":67},120,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults. The main questions it aims to answer are:\n\n1. Would a single session of anodal tPCS over the left prefrontal cortex improve working memory, task inhibition, and task switching in healthy young and older adults, compared to anodal transcranial direct current stimulation (tDCS) and sham-tPCS?\n2. Would repeated session of anodal-tPCS (2-weeks) lead to improvements in working memory, task inhibition, and task switching in healthy young and older adults, compared to tDCS and sham-tPCS?\n3. Will tPCS be better tolerated among healthy adults, compared to tDCS?\n\nResearchers will compare tPCS \u002F tDCS \u002F sham-tPCS to see if there are any differences in cognitive outcomes after 1 session and after repeated sessions, as well as to compare the tolerance of tPCS against tDCS and sham-tPCS.\n\nParticipants will be requested to:\n\n* Undergo 1 of 3 of the following conditions: tDCS \u002F tPCS \u002F sham-tPCS\n* Complete three sessions of cognitive tasks testing working memory, inhibition and task switching at baseline (pre-stimulation), after day 1 of brain stimulation and after 10 sessions of brain stimulation (post- repeated stimulation)\n* Undergo fNIRS-EEG brain measurements concurrently with the cognitive tasks",[9,73,74,75],"Ageing","Executive Functioning","Transcranial Electric Stimulation",[77,78,74,79,80,81,73],"Randomised Controlled Trial","Non-Invasive Brain Stimulation","Transcranial Direct Current Stimulation","Transcranial Pulsed Current Stimulation","Healthy Adults","NOT_YET_RECRUITING","2025-05-18",{"date":85,"type":86},"2025-05-28","ACTUAL",{"date":88,"type":67},"2025-06-01",{"date":90,"type":67},"2027-04-30",{"name":5,"class":6}]