[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634395":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":65,"collaborators":67,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":26,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":95,"whyStopped":26,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Foundation University Islamabad","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Oral Probiotics","EXPERIMENTAL","Participants receive oral probiotic sachets (Ecotec®) once daily for 12 weeks. Each sachet contains a combination of Lactobacillus acidophilus, Bifidobacterium species, Streptococcus thermophilus, and Lactobacillus delbrueckii. The sachet is dissolved in water and taken after meals.Describe the intervention(s) to be administered.\n\nFor drugs use generic name and include dosage form, dosage, frequency and duration.",[13],"Dietary Supplement: Probiotics",{"label":15,"type":16,"description":17,"interventionNames":18},"Oral Plecebo","PLACEBO_COMPARATOR","Participants receive a placebo sachet identical in appearance, taste, and packaging to the probiotic, administered once daily for 12 weeks. The placebo contains inactive ingredients with no therapeutic effect.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Probiotics","Participants will receive a standardized multi-strain oral probiotic (Ecotec sachet) once daily for 12 weeks alongside standard acne care. The formulation contains Lactobacillus and Bifidobacterium species aimed at modulating the gut-skin axis and reducing systemic inflammation.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Participants will receive a placebo sachet identical in appearance, taste, and packaging to the probiotic, administered once daily for 12 weeks alongside standard acne care. The placebo contains inert ingredients with no active probiotic strains, ensuring blinding and allowing accurate comparison of treatment outcomes.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Dr. Aima Tariq, FCPS, Fellowship in Derma","CONTACT","+923359844189","aimatariq1@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Dr. Arfan ul Bari, FCPS Derma","+923016547007","albariul@gmail.com",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Fauji Foundation Hospital, Rawalpindi","Rawalpindi","Punjab Province","46000","Pakistan","PK",{"type":50,"coordinates":51},"Point",[52,53],73.0479,33.59733,{"lat":53,"lon":52},[56,58,62],{"name":57,"role":34,"phone":35,"phoneExt":26,"email":36},"Dr. Aima Tariq, FCPS",{"name":59,"role":34,"phone":60,"phoneExt":26,"email":61},"Dr. Ayesha Saeed, Ph.D. Biotechnology","+923325756579","ayeshasaeed@fui.edu.pk",{"name":63,"role":64,"phone":26,"phoneExt":26,"email":26},"Aima Tariq, FCPS","PRINCIPAL_INVESTIGATOR",{"type":66,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[68],{"name":69,"class":6},"Fauji Foundation Hospital","100634395","investigating-the-efficacy-of-oral-probiotics-versus-placebo-in-pakistani-patients-with-moderate-acne-on-acne-lesion-count-and-systemic-inflammation-100634395",false,"NCT07539129","Investigating the Efficacy of Oral Probiotics Versus Placebo in Pakistani Patients With Moderate Acne on Acne Lesion Count and Systemic Inflammation","A Randomized Controlled Trial Investigating the Efficacy of Oral Probiotics Versus Placebo in Pakistani Patients With Moderate Acne on Acne Lesion Count and Systemic Inflammation (Interleukin-6) Levels","Acne vulgaris","Inclusion Criteria:\n\n* Male and female patients aged 15-35 years\n* Clinical diagnosis of moderate acne vulgaris\n* Fitzpatrick skin types III-V\n* Willing to provide informed consent and comply with study protocol\n\nExclusion Criteria:\n\n* Severe nodulocystic acne, acne conglobata, or acne fulminans\n* Oral antibiotics, isotretinoin, or hormonal therapy within past 4 weeks\n* Topical anti-acne therapy within past 2 weeks\n* Current probiotic supplementation\n* Chronic inflammatory or autoimmune disease\n* Pregnancy or lactation","ALL","15 Years","35 Years",{"count":82,"type":83},64,"ESTIMATED","INTERVENTIONAL",[86],"NA","This randomized controlled trial evaluates the efficacy of oral probiotics compared to placebo in Pakistani patients with moderate Acne Vulgaris. Acne is a multifactorial inflammatory disorder influenced by microbial colonization, seborrhea, and immune dysregulation. Rising antibiotic resistance necessitates alternative therapeutic approaches. Emerging evidence highlights the gut-skin axis, suggesting probiotics may reduce systemic inflammation and acne severity. A total of 64 patients will be randomized into probiotic and placebo groups and treated for 12 weeks. The primary outcome is reduction in total acne lesion count, while the secondary outcome is change in serum Interleukin-6 levels. Clinical assessment includes lesion counts, GAGS scoring, and standardized photography. IL-6 levels will be measured using ELISA at baseline and study completion. Data will be analyzed using SPSS with appropriate statistical tests, considering p ≤ 0.05 as significant. This study aims to provide evidence for probiotics as a safe, effective, and antibiotic-sparing option in acne management, particularly in South Asian populations.",[89],"Acne Vulgaris",[89,91,23,92,93,94],"Modrate Acne","Inflammatory markers","Interleukin 6","Ecotec TM","NOT_YET_RECRUITING","2026-04-13",{"date":98,"type":99},"2026-04-20","ACTUAL",{"date":101,"type":83},"2026-09-01",{"date":103,"type":83},"2027-08-01",{"name":5,"class":6},1]