[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556390":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":47,"collaborators":20,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":20,"eligibilityCriteria":55,"healthyVolunteers":52,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":20,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"SEEG recordings and SPES effects","EXPERIMENTAL","Single-pulse electrical stimulation (SPES) evokes transient neuronal responses that propagate through functional networks, providing a powerful tool to map brain connectivity. When delivered at low frequencies (0.05 Hz, every 20 s), SPES allows quantitative assessment of dynamic network interactions while avoiding long-term synaptic modifications. These stimulation-induced responses, recorded via stereoelectroencephalography (SEEG), reveal both local and distributed neural activity with millisecond precision.",[13],"Procedure: SEEG recordings and SPES",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","SEEG recordings and SPES","This study will utilize stereoelectroencephalography (SEEG) recordings combined with single-pulse electrical stimulation (SPES) to investigate functional brain connectivity and cortical excitability patterns in patients with epilepsy during both wakefulness and sleep states. The SEEG recordings will provide high-resolution intracranial electrophysiological data, while SPES will be employed to actively probe and quantify cortico-cortical connections. This combined approach will enable characterization of state-dependent neural network dynamics.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Liankun Ren, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","13681576621","renlk2022@outlook.com",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Beijing","Beijing Municipality","100000","China","CN",{"type":39,"coordinates":40},"Point",[41,42],116.39723,39.9075,{"lat":42,"lon":41},[45],{"name":23,"role":27,"phone":46,"phoneExt":20,"email":29},"+86 13681576621",{"type":24,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Liankun_Ren","Professor","100556390","investigating-the-functional-characteristics-during-wakefulness-and-sleep-based-on-seeg-100556390",false,"NCT06524479","Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG","Inclusion Criteria:\n\n* Drug-resistant focal epilepsy\n* Justified SEEG exploration in the context of presurgical assessment of epilepsy\n* Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis\n* Written non-opposition to study participation\n\nExclusion Criteria:\n\n* Pregnant women (Contraindication to SEEG exploration)\n* Subjects that experience surgical complications during the implant procedure will be excluded from the study","ALL","14 Years","65 Years",{"count":60,"type":61},20,"ESTIMATED","INTERVENTIONAL",[64],"NA","This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG. The collected data will be analyzed to investigate the functional connectivity during wakefulness and sleep states.",[67,68],"Refractory Epilepsy","Sleep",[70,71],"homeostatic sleep pressure","synaptic plasticity","2025-06-24",{"date":74,"type":75},"2025-06-27","ACTUAL",{"date":77,"type":75},"2024-07-08",{"date":79,"type":61},"2027-10-08",{"name":5,"class":6},1]