[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570537":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":18,"responsibleParty":31,"collaborators":35,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":42,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":18,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":65,"whyStopped":18,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":18},{"fullName":5,"class":6},"Nottingham Trent University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"12-week physical activity programme","EXPERIMENTAL","Participants in this arm will engage in a structured 12-week walking program. They will complete sub-maximal fitness assessments and provide biological samples during visits to the university at baseline, week 6, and week 12. They will also complete questionnaires assessing IBS symptoms, quality of life (QoL), anxiety, depression, and other factors.",[13],"Behavioral: Physical Activity",{"label":15,"type":16,"description":17,"interventionNames":18},"No intervention control group","NO_INTERVENTION","Participants in this arm will not receive any intervention and will continue their usual lifestyle for the study duration. They will complete the same assessments as the intervention arm, including providing biological samples, undergoing sub-maximal fitness tests, and completing questionnaires at baseline, week 6, and week 12. This arm serves as a comparison group to evaluate the effects of the walking program.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Physical Activity","This intervention involves a structured 12-week walking program designed to increase routine physical activity among participants diagnosed with IBS. The intervention focuses on moderate-intensity walking, performed regularly, in line with World Health Organisation (WHO) guidelines with the aim of relieving IBS symptoms.\n\nKey elements include:\n\nParticipants will be guided to adhere to an individualised walking protocol, ensuring consistency in activity levels.\n\nPhysical activity levels will be monitored using self-reported diaries and wearable activity trackers to ensure compliance.\n\nParticipants will also attend three scheduled visits to the university (baseline, week 6, and week 12) for biological sample collection, sub-maximal fitness assessments, and the completion of validated questionnaires on IBS symptoms, quality of life (QoL), anxiety, and depression.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Hannah B Lindsell","CONTACT","+44 (0)115 848 5535","hannah.lindsell@ntu.ac.uk",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Hannah Lindsell","Ms",[36,38],{"name":37,"class":6},"Nottingham University Hospitals NHS Trust",{"name":39,"class":6},"University of Reading","100570537","investigating-the-gut-microbiome-and-symptomology-in-ibs-100570537",false,"NCT06708533","Investigating the Gut Microbiome and Symptomology in IBS","Investigating the Gut Microbiome and Symptomology in IBS: Mechanisms and Therapeutic Implications for Symptom Relief Through Prescribed Physical Activity in Clinical Practice","MICROFIT","Inclusion Criteria:\n\n* Be 18-64 years old\n* Have CLINCALLY DIAGNOSED IBS\n* Know your IBS-SUBTYPE (e.g., constipation, diarrhoea, mixed\u002Falternating)\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding\n* Organic gastrointestinal conditions (Inflammatory Bowel Disease, Coeliac Disease, Colorectal Cancer)\n* On medication with known influence on gastrointestinal motility (thyroid disease, diabetes mellitus, coeliac disease and neurological disease)\n* Have used antibiotics in the past 3 months\n* Currently using opioid pain medications (except occasional\u002Fnon-daily use of NSAIDs)\n* Regular consumption of pre- and probiotic foods\u002Fsupplements\n* Completing more than 300-minutes of PA per week","ALL","18 Years","64 Years",{"count":52,"type":53},40,"ESTIMATED","INTERVENTIONAL",[56],"NA","This intervention study explores whether a routine physical activity intervention can help manage or relieve symptoms of Irritable Bowel Syndrome (IBS) in adults who have been clinically diagnosed with IBS. The main questions it aims to answer is:\n\n• Primary Outcome: Does engaging in routine physical activity reduce the severity of IBS symptoms compared to baseline levels?\n\nComparison Group: Researchers will compare the intervention group (receiving the 12-week physical activity program) with a control group (receiving no intervention for 12-weeks).\n\nParticipant Activities and Interventions:\n\n* Complete a 12-week walking programme.\n* Visit the university on 3 occasions (baseline, week-6 and week-12) for biological sample collection and sub-maximal fitness assessments.\n* Complete a series of subjective health related questionnaires.",[59],"Irritable Bowel Syndrome (IBS)",[22,61,62,63,64],"Irritable Bowel Syndrome","Gut Microbiome","Exercise","IBS","NOT_YET_RECRUITING","2024-11-25",{"date":68,"type":69},"2024-11-27","ACTUAL",{"date":71,"type":53},"2025-03",{"date":73,"type":53},"2025-12",{"name":5,"class":6}]