[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631531":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":52,"collaborators":26,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":26,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":26,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":75,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"National Taiwan University Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Cold Atmospheric Plasma (CAP) + Standard Wound Care","EXPERIMENTAL","Participants in this arm will receive standard. Extracorporeal Life Support(ECLS) wound care in addition to cold atmospheric plasma (CAP) treatment. cold atmospheric plasma (CAP) will be applied directly to the cannulation site wound using a CE\u002FTFDA-approved medical device according to manufacturer guidelines. Treatment will be performed approximately 2-5 times per week, with an application duration of about 60-120 seconds per cm² of wound area. The procedure will be conducted by trained clinical personnel under sterile conditions.\n\nStandard wound care will include routine antiseptic dressing changes, maintenance of cannula site sterility, and systemic antibiotic therapy as clinically indicated. The combined approach aims to reduce bacterial burden, disrupt biofilm formation, modulate local inflammation, and promote wound healing.",[13,14],"Device: Cold Atmospheric Plasma (CAP) Therapy","Device: Standard wound care",{"label":16,"type":17,"description":18,"interventionNames":19},"Standard Wound Care","PLACEBO_COMPARATOR","Participants in this arm will receive standard extracorporeal life support (ECLS)E wound care alone without cold atmospheric plasma (CAP) treatment. Standard care will follow institutional wound management protocols and may include routine antiseptic dressing changes, maintenance of sterility around the cannulation site, regular wound assessment, and systemic antibiotic therapy as clinically indicated. This arm serves as the comparator for evaluating the additional effect of cold atmospheric plasma (CAP) on wound infection, microbial burden, inflammation, and healing outcomes.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Cold Atmospheric Plasma (CAP) Therapy","Cold atmospheric plasma (CAP) therapy is a non-thermal, non-invasive treatment that delivers ionized gas containing reactive oxygen and nitrogen species (RONS), ultraviolet photons, and transient electric fields to the wound surface. In this study, Cold atmospheric plasma (CAP) will be applied directly to extracorporeal life support (ECLS) cannulation site wounds using a CE\u002FTFDA-approved medical device, following manufacturer-recommended parameters (approximately 60-120 seconds per cm² per session, administered 2-5 times per week).\n\nThe treatment is performed under sterile conditions by trained clinical personnel and is used as an adjunct to standard wound care. Cold atmospheric plasma (CAP) is designed to reduce microbial load, including biofilm-associated organisms, modulate local inflammatory responses, and promote tissue regeneration without causing thermal damage to surrounding healthy tissue.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard wound care","Standard wound care consists of routine management of extracorporeal life support (ECLS) cannulation site wounds according to institutional protocols. This includes regular antiseptic dressing changes (e.g., chlorhexidine- or povidone-iodine-based solutions), maintenance of a sterile environment around the cannulation site, and careful monitoring for signs of infection or complications.\n\nAdditional care may include wound cleaning, debridement as clinically indicated, and the use of systemic antibiotics based on clinical judgment and microbiological findings. All procedures are performed by trained healthcare professionals following established clinical guidelines to support wound healing and prevent infection.",[9,16],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"CHIH-YANG CHAN","CONTACT","+886-975810806","chanchihyang@gmail.com",[38],{"facility":5,"status":39,"city":40,"state":26,"zip":26,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Taipei","Taiwan","TW",{"type":44,"coordinates":45},"Point",[46,47],121.52639,25.05306,{"lat":47,"lon":46},[50],{"name":33,"role":34,"phone":51,"phoneExt":26,"email":36},"+886-972651147",{"type":53,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100631531","investigating-the-impact-of-cold-atmospheric-plasma-treatment-on-wound-healing-at-cannulation-sites-in-patients-following-extracorporeal-life-support-100631531",false,"NCT07501897","Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Receiving extracorporeal life support (ECLS)\n* Presence of cannulation site wound requiring wound care\n\nExclusion Criteria:\n\n* Pre-existing severe dermatological conditions at the cannulation site\n* Severe coagulopathy precluding local intervention\n* Concurrent receipt of other experimental wound treatments\n* Life expectancy \\\u003C 48 hours","ALL","18 Years",{"count":63,"type":64},65,"ESTIMATED","INTERVENTIONAL",[67],"NA","This study aims to evaluate a new wound treatment called cold atmospheric plasma (CAP) for patients receiving extracorporeal life support (ECLS). Patients on extracorporeal life support (ECLS) often develop wounds at the sites where tubes are inserted, and these wounds can be difficult to heal and prone to infection.\n\ncold atmospheric plasma (CAP) is a gentle, non-heat treatment that can kill bacteria, reduce inflammation, and promote wound healing. In this study, patients will be randomly assigned to receive either standard wound care alone or standard care plus cold atmospheric plasma (CAP) treatment.\n\nResearchers will compare both groups to see whether cold atmospheric plasma (CAP) can reduce infection, improve healing speed, and decrease the need for additional procedures. The study will also monitor safety to ensure the treatment is well tolerated.\n\nThe goal is to find a more effective and safe way to improve wound healing in critically ill patients.",[70,71,72,73,74],"ExtraCorporeal Life Support (ECLS)","Wound Infection","Surgical Site Infection","Delayed Wound Healing","Biofilm-Associated Infection",[76,77],"Extracorporeal Life Support","cold atmospheric plasma","2026-03-25",{"date":80,"type":81},"2026-03-30","ACTUAL",{"date":83,"type":81},"2026-03-12",{"date":85,"type":64},"2026-12-31",{"name":5,"class":6},1]