[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607348":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":49,"collaborators":20,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":20,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Nova Southeastern University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Transcutaneous electrical stimulation to reduce facial pain and improve jaw ROM in ALS and PLS.","EXPERIMENTAL","All 10 participants will receive a single TENS intervention, with electrodes placed over the masseter and TMJ regions. This intervention is designed to evaluate TENS as a potential treatment for reducing facial pain and improving jaw mobility and chewing function in individuals with ALS and PLS..",[13],"Device: Transcutaneous Electrical Nerve Stimulation to reduce facial pain and improve jaw range of motion in ALS and PLS",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Transcutaneous Electrical Nerve Stimulation to reduce facial pain and improve jaw range of motion in ALS and PLS","TENS intervention will be administered using a current-controlled TENS device that produces charge-balanced, symmetrical biphasic rectangular pulses. Participants will be seated and skin cleaned prior to applying 2 self-adhesive round surface electrodes (25mm) on each side of the face. One electrode (anode) will be placed over the masseter muscle belly, while the other (cathode) will be positioned over the TMJ. Electrode placement will be confirmed by palpation of the TMJ and Masseter. This set up will be mirrored on the opposite side. Once all 4 electrodes are in place, the TENS unit will be turned on.\n\nParticipants will remain seated. The TENS unit will be set to manual mode to deliver the stimulation at a frequency of 50 Hertz (Hz) and a pulse width of 200 microseconds (µseconds). Stimulation amplitudes will be gradually increased from 0 milliamps (mA) to each participant's tolerance level. The 30 minute TENS intervention will then take place.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Kayla Chomko, PT, DPT","CONTACT","954-817-5730","kayla.chomko@nova.edu",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Raquel Garcia, SLP.D, CCC-SLP, BCS-S","954-914-5447","rw602@nova.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Nova Southeastern University, David and Cathy Husman Neuroscience Institute","RECRUITING","Davie","Florida","33314","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-80.2331,26.06287,{"lat":44,"lon":43},[47,48],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},{"type":50,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100607348","investigating-the-impact-of-electrical-stimulation-on-facial-pain-jaw-movement-and-oral-health-in-people-with-motor-neuron-disease-100607348",false,"NCT07187388","Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.","The Impact of Transcutaneous Electrical Stimulation on Facial Pain, Jaw Mobility, and Oral Health in Individuals With Motor Neuron Disease.","MND","Inclusion Criteria:\n\n* Diagnosis of possible, probable, or definite ALS (El-Escorial Revisited) OR diagnosis of definite PLS by the treating neurologist and based on the consensus diagnostic criteria for PLS\n* Subjective report of jaw pain, indicated by a NRS score of \\> or = 3\u002F10.\n\nExclusion Criteria:\n\n* history of head or neck cancer\n* history of CVA\n* history of past facial surgery with hardware placement\n* history of pacemaker\n* diagnosis of significant cognitive impairment by the treating physician\n* history of seizures or diagnosis of epilepsy\n* open wound at the area of electrode placement\n* complete loss of sensation at the area of electrode placement","ALL","18 Years",{"count":62,"type":63},10,"ESTIMATED","INTERVENTIONAL",[66],"NA","The goal of this clinical trial is to evaluate the impact of non-invasive electrical stimulation, when placed on the facial muscles can reduce facial pain and improve jaw mobility, and chewing in individuals with Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS). The secondary goal is to evaluate the impact of non-invasive electrical stimulation on patient reported difficulty performing oral hygiene tasks in individuals with ALS and PLS. Participants will attend one in-person clinic visit and participate in one telephone interview 24 hours after the treatment. The clinic visit will include pre-intervention assessments, a single 30-minute treatment of electrical stimulation followed by post-intervention assessments.\n\nThe assessments will include a self-rating of jaw and facial pain, a range of motion test where participants will be asked to open their jaw as wide and as far to the side as possible, and a chewing efficiency test using a saltine cracker. Twenty-four hours later, participants will receive a follow-up phone call to self-rate their facial pain and report any difficulty performing oral hygiene tasks.\n\nThe treatment consists of a single 30-minute electrical stimulation session. Electrode pads will be placed on the participant's facial region, specifically over the masseter muscle belly and the TMJ area, while the participant is seated comfortably. The pads will be connected to an FDA-approved electrical stimulator, and the current will be adjusted to the participant's comfort level. Once set, the participant will remain seated for 30 minutes. At the end of the session, the stimulator will be turned off and the electrode pads removed.",[69,70,71],"Amyotrophic Lateral Sclerosis (ALS)","Primary Lateral Sclerosis (PLS)","Motor Neuron Disease, Amyotrophic Lateral Sclerosis",[73,74,75,76,77,57,78,79],"Amyotrophic Lateral Sclerosis","Primary Lateral Sclerosis","ALS","PLS","Motor Neuron Disease","Facial Pain","jaw pain","2026-05-22",{"date":82,"type":83},"2026-05-27","ACTUAL",{"date":85,"type":83},"2026-04-02",{"date":87,"type":63},"2026-08-13",{"name":5,"class":6},1]