[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100380359":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":32,"responsibleParty":52,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Weight loss surgery",null,"Gastric bypass surgery will be followed by weight loss as standard of care. Liver fibrosis by elastography will be determined before surgery.",[13],"Procedure: Bariatric surgery",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Bariatric surgery","Evaluate liver fibrosis by elastography before gastric bypass surgery.",[9],[21],"Roux en Y gastric bypass, sleeve gastrectomy",[23],{"name":24,"affiliation":5,"role":25},"Elena Anna O De Filippis","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Keegan M Stewart","CONTACT","480-301-4164","stewart.keegan@mayo.edu",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Mayo Clinic in Arizona","RECRUITING","Scottsdale","Arizona","85259","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-111.89903,33.50921,{"lat":45,"lon":44},[48,50],{"name":49,"role":29,"phone":30,"phoneExt":10,"email":31},"Stewart Keegan",{"name":51,"role":25,"phone":10,"phoneExt":10,"email":10},"Elena De Filippis, MD,PhD",{"type":25,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Elena Anna (Eleanna) De Filippis, M.D., Ph.D.","Principal Investigator","100380359","investigating-the-link-between-type-2-immunity-and-nafld-in-human-obesity-100380359",false,"NCT04232566","Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity","Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity- AIM 1","Inclusion Criteria:\n\n* Undergoing gastric bypass surgery\n* Confirmed AUROC F=0 or F\\>2 liver fibrosis\n* Age 30-70 years\n* BMI greater than 40 kg\u002Fm2\n* Negative pregnancy test (female only)\n* Lab Values: Normal TSH\n\nExclusion Criteria:\n\n* Autoimmune diseases\n* Hepatitis B or C positive\n* Heavy alcohol use\n* Active smoking history\n* Active cancer history\n* History of asthma\n* History of COPD\n* Taking Plavix or Coumadin\n* Blood donation within past 2 months\n* Glucocorticoid Therapy\n* Taking antihistamine on regular basis",true,"ALL","30 Years","70 Years",{"count":67,"type":68},60,"ESTIMATED","OBSERVATIONAL","This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.",[72,73,74],"Obesity, Morbid","NASH - Nonalcoholic Steatohepatitis","Chronic Inflammation",[76,77,78,79],"obesity","nash","adipose tissue inflammation","insulin resistance","2026-01-26",{"date":82,"type":83},"2026-01-28","ACTUAL",{"date":85,"type":83},"2022-02-20",{"date":87,"type":68},"2027-12-30",{"name":5,"class":6},1]