[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544864":3},{"organization":4,"armGroups":7,"interventions":45,"overallOfficials":50,"centralContacts":69,"locations":75,"responsibleParty":91,"collaborators":94,"id":106,"slug":107,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":50,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":50,"overallStatus":77,"whyStopped":50,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Università Vita-Salute San Raffaele","OTHER",[8,14,19,24,30,35,40],{"label":9,"type":10,"description":11,"interventionNames":12},"Occipital tACS at IAF-2Hz","EXPERIMENTAL","Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency below the individual alpha frequency (IAF-2 Hz).",[13],"Procedure: Occipital tACS at IAF-2Hz",{"label":15,"type":10,"description":16,"interventionNames":17},"Occipital tACS at IAF+2Hz","Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency above the individual alpha frequency (IAF+2 Hz).",[18],"Procedure: Occipital tACS at IAF+2Hz",{"label":20,"type":10,"description":21,"interventionNames":22},"Frontal tACS at 4-7 Hz","Transcranial alternating current stimulation (tACS) at frontal sites to modulate the frontal brain areas' activity at a frequency within the theta band (4-7 Hz).",[23],"Procedure: Frontal tACS at 4-7 Hz",{"label":25,"type":26,"description":27,"interventionNames":28},"Sham\u002Fplacebo tACS","SHAM_COMPARATOR","Transcranial alternating current stimulation (tACS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective.",[29],"Procedure: Sham\u002Fplacebo tACS",{"label":31,"type":10,"description":32,"interventionNames":33},"Occipital tRNS","Stimulation at occipital sites with transcranial random noise stimulation (tRNS) to modulate occipital brain areas plasticity",[34],"Procedure: Occipital tRNS",{"label":36,"type":10,"description":37,"interventionNames":38},"Frontal tRNS","Stimulation at frontal sites with transcranial random noise stimulation (tRNS) to modulate frontal brain areas plasticity",[39],"Procedure: Frontal tRNS",{"label":41,"type":26,"description":42,"interventionNames":43},"Sham\u002Fplacebo tRNS","Transcranial random noise stimulation (tRNS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective.",[44],"Procedure: Sham\u002Fplacebo tRNS",[46,51,54,57,60,63,66],{"type":47,"name":9,"description":48,"armGroupLabels":49,"otherNames":50},"PROCEDURE","tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)",[9],null,{"type":47,"name":15,"description":52,"armGroupLabels":53,"otherNames":50},"tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)",[15],{"type":47,"name":20,"description":55,"armGroupLabels":56,"otherNames":50},"tACS applied to frontal areas at 4-7 Hz",[20],{"type":47,"name":31,"description":58,"armGroupLabels":59,"otherNames":50},"tRNS applied to occipital brain regions",[31],{"type":47,"name":36,"description":61,"armGroupLabels":62,"otherNames":50},"tRNS applied to frontal brain regions",[36],{"type":47,"name":25,"description":64,"armGroupLabels":65,"otherNames":50},"tACS is activated only for 30 seconds and then turned off, thus resulting ineffective",[25],{"type":47,"name":41,"description":67,"armGroupLabels":68,"otherNames":50},"tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective",[41],[70],{"name":71,"role":72,"phone":73,"phoneExt":50,"email":74},"Luca Ronconi, PhD","CONTACT","0226434887","ronconi.luca@unisr.it",[76],{"facility":5,"status":77,"city":78,"state":50,"zip":79,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":88},"RECRUITING","Milan","20132","Italy","IT",{"type":83,"coordinates":84},"Point",[85,86],9.18951,45.46427,{"lat":86,"lon":85},[89],{"name":90,"role":72,"phone":73,"phoneExt":50,"email":74},"Luca Ronconi",{"type":92,"investigatorFullName":90,"investigatorTitle":93,"investigatorAffiliation":5,"oldNameTitle":50,"oldOrganization":50},"PRINCIPAL_INVESTIGATOR","Professor",[95,98,100,102,104],{"name":96,"class":97},"Alessia Santoni","UNKNOWN",{"name":99,"class":97},"Sara Stottmeier",{"name":101,"class":97},"Klara Hemmerich",{"name":103,"class":97},"Giuseppe Di Dona",{"name":105,"class":97},"Luigi Ferini-Strambi","100544864","investigating-the-plasticity-of-human-predictive-coding-through-neuromodulation-100544864",false,"NCT06374433","Investigating the Plasticity of Human Predictive Coding Through Neuromodulation","Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers","PREDICOM","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study.\n* Aged 18-35 years.\n* Normal or corrected to normal vision, as per anamnestic investigation.\n\nExclusion Criteria:\n\n* Participants with a diagnosis of epilepsy (as per anamnestic investigation).\n* Participants with major neurological disorders (as per anamnestic investigation).\n* Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).\n* Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).",true,"ALL","18 Years","35 Years",{"count":119,"type":120},210,"ESTIMATED","INTERVENTIONAL",[123],"NA","The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.",[126],"Human Brain and Cognition","2024-06-13",{"date":129,"type":130},"2024-06-14","ACTUAL",{"date":127,"type":120},{"date":133,"type":120},"2026-12-31",{"name":5,"class":6},1]