[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614596":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":33,"locations":42,"responsibleParty":60,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":80,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Nottingham","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Chronic Knee Pain",null,"Adults with knee pain lasting over 3 months",[13],"Other: Central Pain Hypersensitivity",{"label":15,"type":10,"description":16,"interventionNames":17},"Fibromyalgia","Adults with Fibromyalgia",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Control Group","Adults without chronic pain conditions",[13],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Central Pain Hypersensitivity","No intervention carried out",[9,19,15],[28,31],{"name":29,"affiliation":5,"role":30},"Stephanie Smith, PhD","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":5,"role":30},"Mathew Piasecki, PhD",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Ben Lightowler, MSc","CONTACT","+44 (0)115 7484098","benjamin.lightowler@nottingham.ac.uk",{"name":29,"role":36,"phone":40,"phoneExt":10,"email":41},"+44 (0) 115 823 1942","Stephanie.Smith2@nottingham.ac.uk",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"University of Nottingham Graduate Entry Medicine and Health, Royal Derby Hospital, Uttoxeter Road, Derby","RECRUITING","Derby","Derbyshire","DE22 3DT","United Kingdom","UK",{"type":52,"coordinates":53},"Point",[54,55],-1.47663,52.92277,{"lat":55,"lon":54},[58],{"name":35,"role":36,"phone":59,"phoneExt":10,"email":38},"+44 (0)1332 724688",{"type":30,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Stephanie Smith","Dr Stephanie Smith","100614596","investigating-the-role-of-central-pain-hypersensitivity-in-skeletal-muscle-neural-drive-100614596",false,"NCT07281651","Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive","Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive, in People With Knee Pain, and in People With Fibromyalgia Syndrome (Pain-Neural Drive)","Pain-Drive","Inclusion Criteria:\n\nKnee pain group\n\n* History of knee pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months\n\nFibromyalgia group\n\n* Fibromyalgia diagnosis (participant self-reporting a previous diagnosis by a clinician)\n* Pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months\n\nControl group\n\n\\- Pain free individuals without known osteoarthritis\n\nExclusion Criteria:\n\n* BMI\\>35\n* Body weight of 250kg or higher\n* Pregnancy (women)\n* Inability to give consent\n* Inability to meet the requirements of clinical assessment\n* Performed strenuous physical exercise in the past 24 hours prior to testing\n* Consumed alcohol on day of testing\n* Consumed caffeine on day of testing",true,"ALL","40 Years",{"count":75,"type":76},135,"ESTIMATED","OBSERVATIONAL","Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia). Pain is often not directly related to the degree of muscle or joint damage. Adaptations of the central nervous system (brain, spinal cord and nerves) often occur in chronic musculoskeletal conditions and can influence how we feel pain (central pain hypersensitivity). Pain can impact on muscle activity and movement. Muscle activity is also governed by nerve signals from the central nervous system (neural drive).\n\nThe goal of this cross-sectional observational study is to investigate whether chronic musculoskeletal pain is associated with altered nerve signalling (neural drive) to skeletal muscles in adults 40 years or over with chronic knee pain, fibromyalgia and healthy pain free volunteers.\n\nThe main questions it aims to answer are:-\n\n* Is central pain hypersensitivity associated with altered nerve signalling to skeletal muscles in adults 40 years or over with chronic pain (knee pain and for fibromyalgia) as well as healthy volunteers?\n* Is altered nerve signalling to skeletal muscles associated with physical function and disability?\n\nParticipants will be asked to:-\n\n* Have sensory testing to determine how they feel pain\n* Complete static leg and arm muscle contractions with electrodes on the skin to measure muscle electrical activity\n* Complete questionnaires\n* Perform a short set of mobility tasks including walking, rising from a chair and balancing.",[9,15],[81,82,15,83,84,85,86],"Chronic Pain","Musculoskeletal Conditions","Muscle Function","Physical Functioning","Disability","Central Aspects of Pain","2025-12-01",{"date":89,"type":90},"2025-12-15","ACTUAL",{"date":92,"type":90},"2025-11-24",{"date":94,"type":76},"2026-09",{"name":5,"class":6},1]