[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622691":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":40,"centralContacts":45,"locations":55,"responsibleParty":89,"collaborators":10,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":94,"sex":99,"minAge":100,"maxAge":10,"enrollmentInfo":101,"targetDuration":10,"studyType":104,"phases":10,"briefSummary":105,"conditions":106,"keywords":109,"overallStatus":114,"whyStopped":10,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Research Center Borstel","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Asthma",null,"Patients with Asthma",[13],"Other: Characterization of the neutrophil granulocyte epigenome",{"label":15,"type":10,"description":16,"interventionNames":17},"COPD","Patients with chronic obstructive pulmonary disease",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Viral pneumonia","Patients suffering from viral pneumonia, e.g. COVID-19 or Influenza",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Bacterial pneumonia","Patients suffering from bacterial pneumonia",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Tuberculosis","Patients treated for tuberculosis",[13,30],"Other: Characterization of the T-cell immune response to to various oxidatively modified mycobacterial antigens",[32,36],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":10},"Characterization of the neutrophil granulocyte epigenome","Characterization of epigenomic differences in neutrophils from patients with different lung diseases (asthma, COPD, pneumonia, tuberculosis, and viral pulmonary infections such as COVID-19 and influenza) by identifying disease-specific epigenetic and functional signatures",[9,23,15,27,19],{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"Characterization of the T-cell immune response to to various oxidatively modified mycobacterial antigens","Investigation of the response (activation\u002Fstimulation) of antigen-specific T cells from patients with tuberculosis to various oxidatively modified mycobacterial antigens, with the aim of determining whether changes in the redox status of these antigens measurably influence the adaptive immune response.",[27],[41],{"name":42,"affiliation":43,"role":44},"Jan Heyckendorf, Prof. Dr. med.","University Hospital Schleswig-Holstein","PRINCIPAL_INVESTIGATOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":10,"email":50},"Tobias Dallenga, Dr. rer. nat.","CONTACT","+49 4537 188 5561","tdallenga@fz-borstel.de",{"name":52,"role":48,"phone":53,"phoneExt":10,"email":54},"Niklas Koehler, Dr. med.","+49 4537 188 8080","studienzentrum@fz-borstel.de",[56,75],{"facility":57,"status":10,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Medical Service Center MVZ, Research Center Borstel, Leibniz Lung Center","Borstel","Schleswig-Holstein","23845","Germany","DE",{"type":64,"coordinates":65},"Point",[66,67],10.20407,53.81586,{"lat":67,"lon":66},[70,71],{"name":52,"role":48,"phone":53,"phoneExt":10,"email":54},{"name":72,"role":48,"phone":73,"phoneExt":10,"email":74},"Barbara Kalsdorf, PD Dr. med.","+49 4537 188 3510","lungenpraxis@fz-borstel.de",{"facility":76,"status":10,"city":77,"state":59,"zip":78,"country":61,"countryCode":62,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Department of Pulmonology, University Hospital Schleswig-Holstein","Kiel","24105",{"type":64,"coordinates":80},[81,82],10.13489,54.32133,{"lat":82,"lon":81},[85,88],{"name":42,"role":48,"phone":86,"phoneExt":10,"email":87},"+49 431 500-22223","Jan.Heyckendorf@uksh.de",{"name":42,"role":44,"phone":10,"phoneExt":10,"email":10},{"type":44,"investigatorFullName":90,"investigatorTitle":91,"investigatorAffiliation":43,"oldNameTitle":10,"oldOrganization":10},"Jan Heyckendorf","Prof. Dr. med. Jan Heyckendorf","100622691","investigation-of-the-effects-of-oxidized-antigens-on-the-t-cell-response-and-the-epigenetic-reprogramming-of-neutrophils-in-lung-diseases---oxigene---100622691",false,"NCT07386912","Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -","OXIGENE","Inclusion Criteria:\n\n* Diagnosis of an acute or chronic inflammatory lung disease, infectious or non-infectious, including asthma, COPD, pneumonia, tuberculosis, or viral pulmonary infection (e.g., COVID-19, influenza).\n* Age ≥ 18 years at the time of informed consent.\n* Ability to provide informed consent and consent to the collection and processing of clinical and laboratory data, as well as to the analysis of blood samples as part of study participation.\n* Sufficient physical condition to undergo a single venous blood draw (approximately 50 mL), as assessed by the treating physician.\n\nExclusion Criteria:\n\n* Active malignant disease or ongoing cancer therapy (e.g., chemotherapy or immunotherapy), due to potential immunological confounding.\n* Immunosuppressive therapy or known severe immunodeficiency that could interfere with the interpretation of cellular immune responses.\n* Pregnancy or breastfeeding, for general research-ethical reasons and to protect vulnerable populations.\n* Acute unstable clinical condition that, in the opinion of the treating physician, makes study participation unreasonable.\n* Known intolerance to blood sampling or relevant hematological disorders that could compromise the safety or feasibility of venipuncture.\n* Lack of capacity to provide informed consent or insufficient understanding of the study content despite supportive explanation.","ALL","18 Years",{"count":102,"type":103},100,"ESTIMATED","OBSERVATIONAL","The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections. By analyzing a single blood sample, the study examines how certain immune cells react during inflammation and infection, and whether lasting changes in these cells influence how strongly the body responds to disease. Although participants do not receive direct medical benefit, the results may help improve future diagnosis and treatment of lung diseases by providing deeper insight into immune responses.",[9,15,107,108,27],"Bacterial Pneumonia","Viral Pneumonia",[110,111,112,113],"neutrophil granulocytes","epigenome","oxidation","antigens","NOT_YET_RECRUITING","2026-01-27",{"date":117,"type":118},"2026-02-04","ACTUAL",{"date":120,"type":103},"2026-02-01",{"date":122,"type":103},"2030-12",{"name":5,"class":6},2]