[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643750":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":73,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Helsinki University Central Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"adult patients undergoing cardiac surgery with cardiopulmonary bypass",null,"All adult (age 18-100 years) patients who underwent open-heart surgery with cardiopulmonary bypass (surgery with a main procedure code in the NCSP classification F category, \"Heart and Great Vessels of the Thorax\", performed on extracorporeal perfusion, procedure code FXA00) in Helsinki University Hospital between January 2021 and March 2026. Exclusion Criteria: Organ transplants (procedure code FQ), hemophilia, von Willebrand disease, or platelet function disorders (ICD-10 codes D65-D69) and essential thrombocythemia (ICD-10 code D75.2).",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Eero Juhani Pesonen, MD, PhD, docent","CONTACT","+358-40-5880781","eero.pesonen@hus.fi",[19],{"facility":20,"status":10,"city":21,"state":10,"zip":22,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Helsinki University Hospital, Meilahti Hospital","Helsinki","00029 HUS","Finland","FI",{"type":26,"coordinates":27},"Point",[28,29],24.93545,60.16952,{"lat":29,"lon":28},[32,34,36,39,41,43,45],{"name":33,"role":15,"phone":16,"phoneExt":10,"email":17},"Eero Pesonen, MD, PhD, docent",{"name":33,"role":35,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":37,"role":38,"phone":10,"phoneExt":10,"email":10},"Minna Ilmakunnas, MD, PhD, docent","SUB_INVESTIGATOR",{"name":40,"role":38,"phone":10,"phoneExt":10,"email":10},"Peter Raivio, MD, PhD, docent",{"name":42,"role":38,"phone":10,"phoneExt":10,"email":10},"Erika Wilkman, MD, PhD, docent",{"name":44,"role":38,"phone":10,"phoneExt":10,"email":10},"Liisa Petäjä, MD, PhD",{"name":46,"role":38,"phone":10,"phoneExt":10,"email":10},"Lotta Joenpolvi, medical student",{"type":35,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Eero Pesonen","MD, PhD, docent","100643750","ionized-calcium-and-bleeding-in-cardiac-surgery-100643750",false,"NCT07634042","Ionized Calcium and Bleeding in Cardiac Surgery","Plasma Ionized Calcium and Perioperative Bleeding in Cardiac Surgery.","Inclusion Criteria:\n\n* age 18-100 years\n* open-heart surgery with cardiopulmonary bypass (surgery with a main procedure code in the NCSP classification F category, \"Heart and Great Vessels of the Thorax\", performed on extracorporeal perfusion, procedure code FXA00)\n* between January 2021 and March 2026\n\nExclusion Criteria:\n\n* organ transplants (procedure code FQ)\n* hemophilia, von Willebrand disease, or platelet function disorders (ICD-10 codes D65-D69)\n* essential thrombocythemia (ICD-10 code D75.2)","ALL","18 Years","100 Years",{"count":61,"type":62},4300,"ESTIMATED","OBSERVATIONAL","This retrospective study investigates the association between perioperative plasma ionized calcium concentration and perioperative bleeding in open-heart surgery. Excluding patients who meet exclusion criteria, the study will include all applicable adult patients who underwent cardiac surgery at Helsinki University Hospital between January 2021 and March 2026. As clinical routine, during both cardiac surgery and the subsequent intensive care period, multiple blood gas analyses were performed, including measurements of plasma ionized calcium concentration. Time-weighted averages of all measurements will be calculated across different phases of surgery (pre-CPB, on -CPB, post-CPB) and the first 24 hours of ICU stay (0-6 h, 6-12 h, 12-24 h). Perioperative bleeding will be assessed using the Universal Definition of Perioperative Bleeding (UDPB) classification validated for cardiac surgery. In addition to chest drain output, this classification accounts for blood products administered to treat bleeding (red blood cells, platelets, and fresh frozen plasma), pharmacological coagulation factor concentrates (fibrinogen\u002Fcryoprecipitate, PCC, aFVIIa) and surgical interventions (open sternum, resternotomy). The association between plasma ionized calcium and UDPB class will be assessed with regression models. The primary analysis will be the association between time-weighted mean plasma ionized calcium level during the post-CPB phase as a continuous variable and dichotomous UDPB (UDPB 3-4 vs. UDPB 0-2) in patients who did not receive blood products during the post-CPB phase. One secondary and two sensitivity analyses will be performed",[66],"Cardiac Surgery Subjects",[68,69,70,71,72],"cardiac surgery","cardiopulmonary bypass","plasma ionized calcium","bleeding","perioperative bleeding","NOT_YET_RECRUITING","2026-06-03",{"date":76,"type":77},"2026-06-08","ACTUAL",{"date":79,"type":62},"2026-06-01",{"date":81,"type":62},"2029-12-31",{"name":5,"class":6},1]