[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510248":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":10,"centralContacts":39,"locations":49,"responsibleParty":67,"collaborators":69,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":10,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":10,"enrollmentInfo":82,"targetDuration":10,"studyType":85,"phases":10,"briefSummary":86,"conditions":87,"keywords":10,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Alberta","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Women with low rubella antibodies",null,"Women with rubella antibodies \\\u003C10 IU\u002FmL",[13,14,15,16],"Diagnostic Test: Serology for antibody levels - Baseline","Diagnostic Test: Serology to assess cell mediated immune (CMI) response - Baseline","Diagnostic Test: Serology for antibody levels - Post third dose of MMR vaccine","Diagnostic Test: Serology to assess CMI - Post third dose of MMR vaccine",{"label":18,"type":10,"description":19,"interventionNames":20},"Women with high rubella antibodies","Women with rubella antibodies ≥10 IU\u002FmL",[13,14],[22,27,31,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Serology for antibody levels - Baseline","Measurement of rubella IgG antibody levels at baseline",[18,9],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Serology to assess cell mediated immune (CMI) response - Baseline","Assessment of cell mediated immune (CMI) response to measles, mumps, rubella, and varicella at baseline.",[18,9],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Serology for antibody levels - Post third dose of MMR vaccine","Measurement of rubella IgG antibody levels post third dose of MMR vaccine",[9],{"type":23,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"Serology to assess CMI - Post third dose of MMR vaccine","Assessment of cell mediated response (CMI) to measles, mumps, rubella, and varicella post third dose of MMR vaccine.",[9],[40,45],{"name":41,"role":42,"phone":43,"phoneExt":10,"email":44},"Carmen Charlton, PhD","CONTACT","1 (780) 407-8975","carmen.charlton@albertahealthservices.ca",{"name":46,"role":42,"phone":47,"phoneExt":10,"email":48},"Michael H Mengel","17804925943","mmengel@ualberta.ca",[50],{"facility":5,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Edmonton","Alberta","T6G2R3","Canada","CA",{"type":58,"coordinates":59},"Point",[60,61],-113.46871,53.55014,{"lat":61,"lon":60},[64],{"name":65,"role":42,"phone":66,"phoneExt":10,"email":44},"Carmen Charlton","780-407-8975",{"type":68,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[70],{"name":71,"class":72},"Merck Canada Inc.","INDUSTRY","100510248","is-a-third-dose-of-mmrv-vaccine-beneficial-for-the-adult-population-in-alberta-100510248",false,"NCT05923970","Is a Third Dose of MMRV Vaccine Beneficial for the Adult Population in Alberta?","Is a Third Dose of Measles-mumps-rubella-(Varicella) Vaccine (MMR(V)) Vaccine Beneficial for the Adult Population in Alberta?","Inclusion Criteria:\n\n* Women who are pregnant and have undergone routine prenatal screening for rubella antibodies.\n\nExclusion Criteria:\n\n* Women younger than 18 years of age","FEMALE","18 Years",{"count":83,"type":84},200,"ESTIMATED","OBSERVATIONAL","The current recommendation for a full course of measles-mumps-rubella-(varicella) vaccine (MMR(V)) is two doses. The problem is, many individuals within the vaccinated cohort show antibody levels that are below the level considered to be protective, even after two doses of vaccine. Because of these waning antibody levels, it is currently unknown whether highly vaccinated populations are protected from infection against measles, mumps, rubella, or varicella should they be exposed to any of these viruses. The uncertainty of a woman's immune status is partly due to the type of testing that is used to indicate protection. While immunity to viral infection requires both a humoral and a cell mediated immune (CMI) response, only humoral (antibody) responses are measured routinely in the laboratory. This study will examine CMI responses and the role of a third dose of vaccine for previously vaccinated women whose antibody levels are below the cut off. This study will not administer vaccine, but rather will include women who have received a third dose of vaccination through routine health care follow up in the study cohort.",[88,89],"Vaccination Failure","Vaccine Response Impaired","2026-03-12",{"date":92,"type":93},"2026-03-16","ACTUAL",{"date":95,"type":93},"2024-11-09",{"date":97,"type":84},"2027-09-30",{"name":5,"class":6},1]