[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100392462":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":34,"centralContacts":38,"locations":48,"responsibleParty":70,"collaborators":10,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":10,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":10,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":10,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"ART Fertility Clinics LLC","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention",null,"The cortex of selected ovary will be punctured up to ten times. In the surgical report, the surgeon will state how many punctures have been done.",[13,14,15],"Procedure: Ovarian puncture","Other: Hormonal blood Test","Diagnostic Test: Transvaginal ultrasound",{"label":17,"type":10,"description":18,"interventionNames":10},"Control","No intervention",[20,25,29],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Ovarian puncture","Egg collection",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Hormonal blood Test","AMH (ng\u002Fml), FSH (IU\u002FmL), E2(pg\u002FmL), P4(ng\u002FmL), LH (IU\u002FmL)",[9],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"DIAGNOSTIC_TEST","Transvaginal ultrasound","Doppler of arteria ovarica. Resistance index",[9],[35],{"name":36,"affiliation":5,"role":37},"Laura Melado, PhD","PRINCIPAL_INVESTIGATOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"barbara Lawrenz, PhD","CONTACT","+97126528000","1108","jonalyn.edades@artfertilityclinics.com",{"name":46,"role":41,"phone":42,"phoneExt":47,"email":44},"Jonalyn Edades","1122",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Abu Dhabi","Abu Dhabi Emirate","60202","United Arab Emirates","AE",{"type":57,"coordinates":58},"Point",[59,60],54.39696,24.45118,{"lat":60,"lon":59},[63,66,69],{"name":64,"role":41,"phone":65,"phoneExt":10,"email":44},"Barbara Lawrenz, PhD","+97102 652 8000",{"name":67,"role":41,"phone":10,"phoneExt":68,"email":44},"jonalyn edades, RN","+97102 652 800",{"name":36,"role":37,"phone":10,"phoneExt":10,"email":10},{"type":37,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Laura Melado","Principal Investigator","100392462","is-there-a-role-for-mechanical-stimulation-in-ovarian-follicular-activation-100392462",false,"NCT04390308","Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?","Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation? A Randomized Control Trial.","Inclusion Criteria:\n\n* Signed and dated informed consent\n* Women 40 years of age and younger with documented primary ovarian insufficiency (12).\n* Normal Karyotype\n* BMI \\\u003C\u002F= 35 kg\u002Fm2\n* Oligo\u002Famenorrhea for at least 4 months\n* FSH \\> 25 IU\u002FmL\n* AMH \\\u003C\u002F= 0,1 ng\u002Fml\n* No evidence of follicles \\> 4mm\n* Must have two ovaries of approximately equal volume.\n* Willingness to undergo further fertility treatment, including IVF if there is evidence of response\n* A transvaginal scan including Doppler for arteria ovarica will be performed previously to the surgical procedure.\n\nExclusion Criteria:\n\n* Premature ovarian failure due to a genetic origin, such as Turner's Syndrome or chromosomal abnormality.\n* Oncological diseases (specially, skeletal system and blood).\n* Autoimmune diseases, for example, lupus erythematosus, etc.\n* Previous treatments including radiotherapy or chemotherapy.\n* Other conditions not suitable for surgical procedures and\u002For anesthesia.\n* Anticoagulant or antiaggregant treatment.\n* Acute and chronic infectious diseases.\n* Active substance abuse or dependence.\n* Major Mental health disorder.","FEMALE","18 Years","40 Years",{"count":84,"type":85},70,"ESTIMATED","OBSERVATIONAL","Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected. Most patients already had impaired or complete loss of fecundity when diagnosed. Hence, the treatment of POI is particularly tough. Currently, no optimal regimen exists to ameliorate ovarian function.",[89,90,91],"Infertility, Female","Premature Ovarian Failure","IVF","2025-02-17",{"date":94,"type":95},"2025-02-19","ACTUAL",{"date":97,"type":95},"2021-06-02",{"date":99,"type":85},"2025-12-31",{"name":5,"class":6},1]