[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547615":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":46,"collaborators":48,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"University of Leicester","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intracerebral Haemorrhage Patients",null,"Patients with a clinical diagnosis of haemorrhagic stroke on CT imaging within 48 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic). This is a non-intervention study so no intervention will be given. However, the investigators will observe changes in cerebral haemodynamics of this group within 48 hours of stroke onset and within 3-7 days post-onset.",[13],"Device: Transcranial Doppler ultrasonography (TCD)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","Transcranial Doppler ultrasonography (TCD)","TCD will be used to measure cerebral blood velocity (CBv) in the middle and posterior cerebral arteries (MCA and PCA). Following confirmation of a suitable TCD window, participants will undergo a ten-minute rest period in the supine or semi-supine position. Continuous measurements of CBv, blood pressure (BP), heart rate, and end-tidal carbon dioxide will be recorded. Baseline BP will be measured using an automated BP device prior to each recording to allow calibration of the files offline for analysis. This will occur at the first visit and at follow-up, 4-7 days post-onset of intracerebral haemorrhage.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Jatinder Minhas, SFHEA","CONTACT","+44 116 252 3299","jm591@leicester.ac.uk",[27],{"facility":28,"status":29,"city":30,"state":10,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"University Hospitals of Leicester NHS Trust","RECRUITING","Leicester","LE1 5WW","United Kingdom","UK",{"type":35,"coordinates":36},"Point",[37,38],-1.13169,52.6386,{"lat":38,"lon":37},[41,44],{"name":42,"role":23,"phone":43,"phoneExt":10,"email":25},"Jatinder S Minhas, SFHEA","+441162523299",{"name":42,"role":45,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[49],{"name":50,"class":6},"University Hospitals, Leicester","100547615","ischaemic-lesions-in-acute-intracerebral-haemorrhage-100547615",false,"NCT06410274","Ischaemic Lesions in Acute Intracerebral Haemorrhage","Ischaemic Lesions in Acute Intracerebral Haemorrhage: Pathophysiological Investigation Using Novel Multimodal Cerebral and Systemic Haemodynamic Assessments","CHALLENGE-ICH","Inclusion Criteria:\n\n* Clinical diagnosis of a haemorrhagic stroke on CT imaging within 48 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic).\n* Male or female, aged 18 years or above.\n\nExclusion Criteria:\n\n* MRI imaging is contraindicated or unlikely to tolerate scanning process due to clinical instability (GCS \\\u003C8, unable to lie supine).\n* Patients requiring anaesthesia.\n* Male or Female, aged under 18 years.\n* Clinical diagnosis of stroke greater than 48 hours from onset","ALL","18 Years","120 Years",{"count":63,"type":64},120,"ESTIMATED","OBSERVATIONAL","The aim of this observational study is to determine how and why inadequate brain blood flow occurs after bleeding in patients with intracerebral haemorrhage (ICH). Treatment for strokes caused by burst blood vessels involves reducing blood pressure (BP) to stop the bleeding. However, this reduction in BP may affect blood flow, causing blockages in blood vessels within the brain. Fast breathing also affects brain blood flow. Therefore, participants will be asked to undergo a simple brain blood flow assessment using transcranial Doppler (TCD) within 48 hours upon admission to hospital. Patients will then have a follow-up TCD assessment at 4-7 days post-ICH onset, in addition to an MRI scan at \\>7 days. This research will help to confirm if blockages after bleeding are caused by reduced blood flow within the brain.",[68],"Intracerebral Haemorrhage",[70,71,72,73,74],"Stroke","Cerebral Autoregulation","Cerebral Blood Flow","Transcranial Doppler","Magnetic Resonance Imaging","2024-09-17",{"date":77,"type":78},"2024-09-19","ACTUAL",{"date":80,"type":78},"2024-06-01",{"date":82,"type":64},"2029-01-31",{"name":5,"class":6},1]