[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579117":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":37,"locations":43,"responsibleParty":63,"collaborators":29,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":29,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":29,"enrollmentInfo":76,"targetDuration":29,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":46,"whyStopped":29,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Universita di Verona","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive Group (CG)","EXPERIMENTAL","60 minutes of cognitive training with a computerized device",[13],"Device: Cognitive rehabilitation: CG group",{"label":15,"type":10,"description":16,"interventionNames":17},"Motor Group (MG)","60 minutes of robot-assisted gait training with the G-EO System",[18],"Device: Motor rehabilitation: MG group",{"label":20,"type":10,"description":21,"interventionNames":22},"Combined Group (CbG)","30 minutes of cognitive training with a computerized device + 30 minutes of robot-assisted gait training with the G-EO System.",[23],"Device: Combined rehabilitation: CbG group",[25,30,33],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"DEVICE","Cognitive rehabilitation: CG group",[9],null,{"type":26,"name":31,"description":16,"armGroupLabels":32,"otherNames":29},"Motor rehabilitation: MG group",[15],{"type":26,"name":34,"description":35,"armGroupLabels":36,"otherNames":29},"Combined rehabilitation: CbG group","30 minutes of cognitive training with a computerized device + 30 minutes of robot-assisted gait training with the G-EO System. To mitigate the effects of fatigue in sequential training, the patients included in this group will undergo the cognitive (treatment CG) and motor (treatment MG) sessions in a counterbalanced order (half of the participants will follow the CG-MG sequence, and the other half will follow the MG-CG sequence). Five-minute breaks will be provided between the cognitive and motor sessions.",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},"Valentina Varalta","CONTACT","045 8124956","valentina.varalta@univr.it",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Sezione medicina fisica e riabilitativa dipartimento di neuroscienze","RECRUITING","Verona","verona","37134","Italy","IT",{"type":53,"coordinates":54},"Point",[55,56],10.9938,45.43854,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":61,"phoneExt":29,"email":62},"Nicola Smania, Direttore","045 8124573","nicola.smania@univr.it",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Nicola Smania, MD, Clinical Professor","Doctor","100579117","isolated-versus-combined-cognitive-and-motor-high-tech-rehabilitation-100579117",false,"NCT06820125","Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation","Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation in Patients with Multiple Sclerosis","Inclusion Criteria:\n\n* presence of mild (one or two neuropsychological tests below the cut-off score, 5th percentile) or severe (more than two neuropsychological tests below the cut-off score, 5th percentile) cognitive impairment,\n* mild to moderate walking disability with Expanded Disability Status Scale (EDSS) between 3 and 6,\n* no relapse or associated steroid use in the past three months,\n* adequate visual and auditory capacity to operate computer software.\n\nExclusion Criteria:\n\n* presence of other neurological disorders than MS,\n* major psychiatric disorders,\n* high levels of anxiety and\u002For depression (score\\>20 for Depression scale and up to 14 for Anxiety scale on Italian adaptation of the Depression, Anxiety and Stress Scale (DASS-21),\n* substance abuse,\n* any type of rehabilitation intervention in the month prior to recruitment\n* pharmacological therapy not well defined and\u002For changed during the study\n* presence of paroxysmal vertigo\n* lower limb botulinum toxin injections within the previous 12 weeks","ALL","18 Years",{"count":77,"type":78},48,"ESTIMATED","INTERVENTIONAL",[81],"NA","The first aim of this project is to investigate the effects of different high-tech neurorehabilitation interventions (cognitive, motor, and combined cognitive-motor) on both cognitive and motor disability outcomes in people with multiple sclerosis (MS).\n\nThe second aim is to identify the cognitive and motor profiles of MS patients who benefit the most from either the combined cognitive-motor rehabilitation intervention or the isolated cognitive or motor treatments.",[84,85,86,87],"Rehabilitation","Multiple Sclerosis","Cognitive Deficit","Motor Deficits",[89,90,91,92],"rehabilitation","multiple sclerosis","cognitive deficits","motor deficits","2025-02-05",{"date":95,"type":96},"2025-02-11","ACTUAL",{"date":98,"type":96},"2023-07-05",{"date":100,"type":78},"2026-07-05",{"name":5,"class":6},1]