[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567640":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":12,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":12,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":12,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":79,"whyStopped":12,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"National Defense Medical Center, Taiwan","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Active iTBS for Patients With MCI or AD","ACTIVE_COMPARATOR","The patient will receive one daily rTMS session for 10 days of iTBS, delivered through an H-coil applied to the left dorsolateral prefrontal cortex. The TBS frequency parameters consist of 3-pulse 50-Hz bursts every 200 ms at 5 Hz, and the intensity will be set at 80% of the active motor threshold (AMT). A single session of iTBS contains 2 s of TBS repeated every 10 s for 20 times.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Sham iTBS for Patients With MCI or AD","SHAM_COMPARATOR","Sham stimulation will be delivered 10 sessions.",[18],"Device: Sham rTMS",[20,24],{"type":21,"name":22,"description":23,"armGroupLabels":12,"otherNames":12},"DEVICE","Active rTMS","iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions",{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":12},"Sham rTMS","sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions",[14],[29],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},"YU-KAI LIN","CONTACT","886-987-859-907","yukai0907@ndmctsgh.edu.tw",[35],{"facility":36,"status":12,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Tri-Service General Hospital","Taipei","Other","114","Taiwan","TW",{"type":43,"coordinates":44},"Point",[45,46],121.52639,25.05306,{"lat":46,"lon":45},[49,52],{"name":50,"role":31,"phone":51,"phoneExt":12,"email":33},"Yu-Kai Lin","886-2-87923311 ext 10552,13907",{"name":12,"role":31,"phone":32,"phoneExt":12,"email":12},{"type":54,"investigatorFullName":50,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","100567640","itbs-in-mci-and-mild-ad-100567640",false,"NCT06670820","iTBS in MCI and Mild AD","The Effects of Intermittent Theta-burst Stimulation on Cognitive Function in Patients With Mild Cognitive Impairment and Mild Alzheimer's Disease and the Role of Brain-Derived Neurotrophic Factor","Inclusion Criteria:\n\n* Clinical diagnosis of MCI (overall Clinical Dementia Rating of 0.5)\n* Clinical diagnosis of mild Alzheimer's Disease (overall Clinical Dementia Rating of 0.5 or 1)\n\nExclusion Criteria:\n\n* History of stroke\n* History of uncontrol seizure\n* History of significant head trauma followed by persistent neurologic deficit or known structural brain abnormality\n* Mental illness\n* Drug abuse","ALL","50 Years","85 Years",{"count":66,"type":67},80,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.",[73,74],"Mild Cognitive Impairment (MCI)","Mild Alzheimer Disease",[76,77,78,74],"rTMS","iTBS","Mild Cognitive Impairment","NOT_YET_RECRUITING","2024-10-31",{"date":82,"type":83},"2024-11-01","ACTUAL",{"date":80,"type":67},{"date":86,"type":67},"2028-12-31",{"name":5,"class":6},1]