[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541337":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":39,"responsibleParty":56,"collaborators":24,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":24,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":24,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":24,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Aalborg University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"1st pruritogen","EXPERIMENTAL","The subproject is conducted in 1 session (approx. 3 hours in total) divided into two parts. In the first part, 3 test areas (3x3 cm) will be selected on one forearm of the subject. The 3 areas will be randomly treated with 1 application of cowhage, 2 applications of cowhage (the second application will be conducted 90 seconds after the first one in the same area), and 2 applications of cowhage (the second application will be conducted 180 seconds after the first one in the same area). Itch will be monitored using a VAS (visual analog scale) for 15 min in each session. After the removal of cowhage, FLPI, alloknesis, and mechanically evoked itch will be measured.",[13],"Other: Histamine",{"label":15,"type":10,"description":16,"interventionNames":17},"2nd pruritogen","The second part will be conducted 20 minutes after the first part, and the procedure will be the same, but using histamine instead of cowhage. The two parts will be randomized between subjects.",[18],"Other: Cowhage",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Histamine","Histaminergic itch will be evoked by a 1% histamine solution. A droplet of histamine solution will be placed on the predetermined area on the forearm, and the SPT lancet will be pierced through the histamine.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Cowhage","25 spicules will be inserted in the center of the predefined skin area on the mandibular area. The spicules will be gently rubbed for 15-20 seconds in circular motion to facilitate epidermal penetration.",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Silvia Lo Vecchio, PhD","CONTACT","+4521397785","slv@hst.aau.dk",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Giulia Erica Aliotta, PhD","50290580","gea@hst.aau.dk",[40],{"facility":5,"status":41,"city":42,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Aalborg","9260","Denmark","DK",{"type":47,"coordinates":48},"Point",[49,50],9.9187,57.048,{"lat":50,"lon":49},[53,55],{"name":31,"role":32,"phone":54,"phoneExt":24,"email":34},"0045+21397785",{"name":31,"role":32,"phone":24,"phoneExt":24,"email":24},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Silvia Lo Vecchio","Associate Professor","100541337","itch-sensation-induced-by-multiple-applications-of-pruritogens-temporal-summation-100541337",false,"NCT06328543","Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)","Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand Englis\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other addictive drugs\n* Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results\n* Lack of ability to cooperate\n* Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids\n* Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)\n* Moles, scars, or tattoos in the area to be treated or tested.\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain\n* Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)",true,"ALL","18 Years","60 Years",{"count":72,"type":73},26,"ESTIMATED","INTERVENTIONAL",[76],"NA","In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.",[21,26],"2024-11-20",{"date":81,"type":82},"2024-11-22","ACTUAL",{"date":84,"type":82},"2024-11-01",{"date":86,"type":73},"2026-12-31",{"name":5,"class":6},1]