[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541336":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":39,"responsibleParty":55,"collaborators":24,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":24,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Aalborg University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"1st pruritogen","EXPERIMENTAL","The subproject consists of 2 sessions 3 days apart. Each session consists of 3 parts.\n\nIn the first session, 3 test areas (4x4 cm) will be selected on the subject's forearms. In part 1, we will apply cowhage in one area. In part 2, we will apply cowhage in two areas on the same arm. In part 3, we will again apply cowhage in 2 areas, one on each arm. In each part, the itch intensity will be measured using a VAS (visual analog scale) for 10 min from the cowhage application. After removal of the cowhage, alloknesis and mechanically evoked itch will be measured in the area selected in part 1.",[13],"Other: Cowhage",{"label":15,"type":6,"description":16,"interventionNames":17},"2nd pruritogen","The second session will take place 3 days after the first one and will follow the same procedure as session 1. However, histamine will be applied instead of cowhage. The order of the two sessions will be randomized.",[18],"Other: Histamine",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Cowhage","25 spicules will be inserted in the center of the predefined skin area on the mandibular area. The spicules will be gently rubbed for 15-20 seconds in circular motion to facilitate epidermal penetration.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Histamine","Histaminergic itch will be evoked by a 1% histamine solution. A droplet of histamine solution will be placed on the predetermined area on the forearm, and the SPT lancet will be pierced through the histamine with 120 g of pressure for 1-2 seconds.",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Silvia Lo Vecchio, PhD","CONTACT","+4521397785","slv@hst.aau.dk",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Giulia Erica Aliotta, PhD","50290580","gea@hst.aau.dk",[40],{"facility":5,"status":41,"city":42,"state":24,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Aalborg","9620","Denmark","DK",{"type":47,"coordinates":48},"Point",[49,50],9.9187,57.048,{"lat":50,"lon":49},[53],{"name":54,"role":32,"phone":33,"phoneExt":24,"email":34},"Silvia Lo Vecchio",{"type":56,"investigatorFullName":54,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Associate Professor","100541336","itch-sensation-induced-by-simultaneous-application-of-pruritogens-spatial-summation-100541336",false,"NCT06328530","Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation)","Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other addictive drugs\n* Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis) musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results\n* Lack of ability to cooperate\n* Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids\n* Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)\n* Moles, scars, or tattoos in the area to be treated or tested.\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain\n* Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)",true,"ALL","18 Years","60 Years",{"count":70,"type":71},24,"ESTIMATED","INTERVENTIONAL",[74],"NA","In This experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. The hypothesis behind this study (spatial summation) is that two simultaneous applications of pruritogens will result in higher itch sensation compared with a single application of pruritogen.",[26,21],"2024-05-03",{"date":79,"type":80},"2024-05-06","ACTUAL",{"date":82,"type":80},"2024-04-01",{"date":84,"type":71},"2026-12-31",{"name":5,"class":6},1]