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an Observational Study","Ivosidenib in Locally Advanced or Metastatic Cholangiocarcinoma With IDH1 R132 Mutation After at Least One Prior Systemic Treatment - a Prospective, Multicenter, Observational Study in Germany","IDHIRA","Inclusion Criteria:\n\n* Age 18 years or older.\n* Histologically confirmed locally advanced or metastatic CCC with a documented IDH1 R132 mutation diagnosed by an appropriate diagnostic test\n* Patients must have at least one prior systemic therapy\n* Decision for treatment with ivosidenib according to current SmPC.\n* Signed written informed consent before or within 6 weeks of first ivosidenib dose (inclusion of patients up to 6 weeks after first ivosidenib intake is allowed for patients not participating in the PRO module)\n* For patients participating in the PRO module (optional):\n\n  * Dated signature of informed consent form before start of study treatment.\n  * Willingness and capability to participate in PRO assessment in German language.\n* Other criteria according to current SmPC.\n\nExclusion Criteria:\n\n* Participation in an interventional clinical trial within 30 days prior to enrolment or concurrent participation in an interventional clinical trial except for the follow-up period.\n* Other contraindications according to current SmPC.","ALL","18 Years",{"count":175,"type":176},100,"ESTIMATED","OBSERVATIONAL","Cholangiocarcinoma is a rare and aggressive tumor of the bile duct associated with a poor prognosis and very limited treatment options. 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