[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639678":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":26,"locations":32,"responsibleParty":61,"collaborators":12,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":12,"enrollmentInfo":73,"targetDuration":12,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":35,"whyStopped":12,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","NO_INTERVENTION","Control group (CR): patients who will receive conventional rehabilitation (CR) in our hospital followed by an intensive conventional rehabilitation (ICR) program at the rehabilitation center.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"IVR group","ACTIVE_COMPARATOR","Intervention group (CR+IVR): patients who will receive, in addition to CR, rehabilitation using the immersive virtual reality (IVR) system in our hospital, followed by the same ICR program as the control group together with IVR therapy at the rehabilitation center.",[18],"Other: Immersive Virtual Reality",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Immersive Virtual Reality","patients who will receive, in addition to CR, rehabilitation using the immersive virtual reality (IVR) system in our hospital, followed by the same ICR program as the control group together with IVR therapy at the rehabilitation center.",[14],[25,9],"IVR Group",[27],{"name":28,"role":29,"phone":30,"phoneExt":12,"email":31},"Yolanda Silva, MD PhD","CONTACT","34972940262","ysilva.girona.ics@gencat.cat",[33],{"facility":34,"status":35,"city":36,"state":12,"zip":12,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Hospital Dr Josep Trueta","RECRUITING","Girona","Spain","ES",{"type":40,"coordinates":41},"Point",[42,43],2.82493,41.98311,{"lat":43,"lon":42},[46,48,51,53,55,57,59],{"name":28,"role":29,"phone":30,"phoneExt":12,"email":47},"neurologia.girona.ics@gencat.cat",{"name":49,"role":50,"phone":12,"phoneExt":12,"email":12},"Mikel Terceño, MD PhD","SUB_INVESTIGATOR",{"name":52,"role":50,"phone":12,"phoneExt":12,"email":12},"Elisvan Rufino",{"name":54,"role":50,"phone":12,"phoneExt":12,"email":12},"Nuria Bas",{"name":56,"role":50,"phone":12,"phoneExt":12,"email":12},"Imma Boada",{"name":58,"role":50,"phone":12,"phoneExt":12,"email":12},"Elisabet Ortiz",{"name":60,"role":50,"phone":12,"phoneExt":12,"email":12},"Carme Gubern",{"type":62,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100639678","ivr-on-upper-limb-rehabilitation-in-stroke-patients-a-clinical-trial-100639678",false,"NCT07609966","IVR ON UPPER-LIMB REHABILITATION IN STROKE PATIENTS: A CLINICAL TRIAL","Impact of Immersive Virtual Reality in the Rehabilitation in the Acute Phase of Stroke: a Clinical Study and Correlation With Blood Biomarkers and Polymorphisms Related to Neuroplasticity","REVICTUS","Inclusion Criteria: Diagnosis of ischemic stroke or intracerebral hemorrhage. Age \\> 18 years. \\\u003C 7 days between stroke onset and inclusion in the study. Impairment of mobility in the right or left upper limb due to stroke. After hospital discharge, patients continue an intensive conventional rehabilitation (ICR) program at their referral rehabilitation center (MUTUAM).\n\nAbility to understand and sign the study informed consent form (ICF) and the IDIBGI Biobank informed consent form.\n\n\\-\n\nExclusion Criteria:\n\nPrevious upper limb disability (neurological or non-neurological cause). Previous dementia or any disease with a life expectancy of less than 1 year. Language comprehension difficulties. Difficulty remembering exercise instructions. History of photosensitive epilepsy.\n\n\\-","ALL","18 Years",{"count":74,"type":75},120,"ESTIMATED","INTERVENTIONAL",[78],"NA","Stroke is the leading cause of acquired disability in adults. Neurorehabilitation aims to recover the affected function by stimulating neuroplasticity. Immersive virtual reality (IVR) has shown that it can be effective but the evidence is still weak. Similarly, few studies have analysed blood biomarkers as outcome or predictive indicators, and knowledge of the influence of genetic polymorphisms on rehabilitation efficacy is limited. Our objectives are (1) to demonstrate that the addition of IVR to conventional rehabilitation (CR) improves upper-limb motor function, functional status, and quality of life in stroke patients, at short and long term; (2) to determine the effect of IVR on the expression of neuroplasticity biomarkers at long term; (3) to evaluate the impact of genetic polymorphisms on the rehabilitation and functional prognosis of treated patients, at short and long term; and (4) to identify acute phase predictive biomarkers of motor recovery and functional prognosis at short and long term. To this end, we propose a single-center, prospective, randomised, controlled, and open label clinical trial with blinded end-point assessment. Adults diagnosed of acute ischaemic\u002Fhaemorrhagic stroke with mobility impaired in the upper-limb and included in a program of intensive CR (ICR) at hospital discharge will be included. Patients will be randomly assigned into two groups: ICR+IVR or only ICR and will be followed for one year to assess, at 3 and 12 months, motor strength in the upper-limb, functional dependence and quality of life. In blood samples obtained at admission (baseline) and at 12 months, proteins and microRNAs will be analysed to identify predictive biomarkers of recovery (motor and functional) and to determine the effect of IVR on neuroplasticity mechanisms. Genetic polymorphisms that may affect motor and functional recovery of patients treated with RC±RVI will also be analysed",[81],"Stroke Acute",[83,84,85],"stroke","virtual reality","rehabilitation","2026-05-20",{"date":88,"type":89},"2026-05-27","ACTUAL",{"date":91,"type":89},"2022-08-31",{"date":93,"type":75},"2026-06",{"name":5,"class":6},1]