[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644207":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":31,"responsibleParty":48,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":70,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University Hospital, Bordeaux","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group",null,"Patients ≥ 18 years old hospitalized in the neurocritical care unit or the trauma unit in clinically stable condition allowing transient positional changes",[13],"Procedure: Ultrasound assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Ultrasound assessment","After the routine nursing care, during patient repositioning to 30 ° assessments are performed at 0, 10° 20° 30°, and at a calculated threshold angle α. At each angle intracranial pressure , cerebral perfusion pressure and ultrasound assessment of cerebral blood flow velocities and internal jugular vein cross-sectional area at three cervical levels are recorded.",[9],[21],{"name":22,"affiliation":5,"role":23},"Grégoire CANE, Dr","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"David ROURE","CONTACT","05 57 87 02 01","+33","david.roure@chu-bordeaux.fr",[32],{"facility":33,"status":10,"city":34,"state":10,"zip":10,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Bordeaux university hospital","Bordeaux","France","FR",{"type":38,"coordinates":39},"Point",[40,41],-0.58046,44.84124,{"lat":41,"lon":40},[44,45,46],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},{"name":22,"role":23,"phone":10,"phoneExt":10,"email":10},{"name":26,"role":47,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100644207","jugular-gating-for-upright-level-adjustment-and-targeted-enhancement-of-cerebral-perfusion-100644207",false,"NCT07665606","JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion","JUGULATE","Inclusion Criteria:\n\n* Patients ≥ 18 years old\n* Hospitalized in the neurocritical care unit or the trauma unit\n* Scheduled for nursing care requiring a supine position.\n* Arterial catheter allowing continuous measurement of mean arterial pressure.\n* Central venous catheter for continuous measurement of central venous pressure.\n* External ventricular drain or intracranial pressure sensor for intracranial pressure monitoring.\n* Bed with controlled inclination capability.\n* Clinically stable condition allowing transient positional changes (as judged by the clinician).\n* Not included, or planned to be included in another trial.\n\nExclusion Criteria:\n\n* Contraindication to trunk mobilization.\n* Being a minor or placed under supervision.\n* Hemodynamic or respiratory instability.\n* Uncontrolled intracranial hypertension, refractory arterial hypertension, or severe dysautonomia.\n* Pregnancy or breastfeeding.\n* Refusal to participate in the study.","ALL","18 Years",{"count":60,"type":61},30,"ESTIMATED","OBSERVATIONAL","Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse. This collapse is estimated to occur at the angle where the hydrostatic pressure of the blood column matches the central venous pressure, and it can be assessed using ultrasonography. This approach allows for the determination of an individualized tilt angle, optimizing cerebral perfusion pressure without compromising venous drainage.",[65,66],"Intracranial Pressure","Critical Care",[65,68,69],"jugular vein collapse","Critical care","NOT_YET_RECRUITING","2026-06-18",{"date":73,"type":74},"2026-06-24","ACTUAL",{"date":76,"type":61},"2026-09-01",{"date":78,"type":61},"2027-03-31",{"name":5,"class":6},1]