[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591264":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":59,"collaborators":62,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":25,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":25,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Wysa for Chronic Pain + JITAIs","EXPERIMENTAL","Participants assigned to the experimental arm will receive access to the Wysa for Chronic Pain app, and the novel JITAIs that are being tested in this study will be incorporated into the app experience.\n\nIn an initial 4-week pilot trial, participants in this arm will receive the JITAIs every time the decision rule (i.e., \"trigger criteria\") is satisfied for that respective JITAI. In subsequent 12-week micro-randomized trials, every time the decision rule for a JITAI is satisfied, participants in this arm will be randomized to receive (versus not receive) the respective JITAI.",[13,14],"Other: Just-In-Time Adaptive Interventions (JITAIs)","Behavioral: Wysa for Chronic Pain",{"label":16,"type":17,"description":18,"interventionNames":19},"Wysa for Chronic Pain without JITAIs","ACTIVE_COMPARATOR","Participants assigned to the control arm will receive access to the Wysa for Chronic Pain app, but the novel JITAIs that are being tested in this study will not be incorporated into the app experience.",[14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Just-In-Time Adaptive Interventions (JITAIs)","JITAIs are digital interventions that aim to deliver support to a user when the person is most in need and receptive to the intervention. In this study, multiple JITAIs will be tested and refined through completion of an iterative series of randomized trials that are interspersed with qualitative participant interviews. The purpose of each JITAI under investigation is to improve engagement with the Wysa for Chronic Pain app.",[9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"BEHAVIORAL","Wysa for Chronic Pain","Wysa for Chronic Pain is an app-based digital mental health intervention that uses a behavioral activation framework and encourages users to work toward pain acceptance. The intervention also includes cognitive behavioral therapy, mindfulness, and sleep tools.",[9,16],[32],{"name":33,"affiliation":5,"role":34},"Abby L. Cheng, MD, MPHS","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Adriana Martin","CONTACT","314-530-9023","azmartin@wustl.edu",{"name":42,"role":38,"phone":43,"phoneExt":25,"email":25},"Research Coordinator","314-747-8489",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":25},"Washington University in St. Louis School of Medicine","RECRUITING","St Louis","Missouri","63110","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-90.19789,38.62727,{"lat":57,"lon":56},{"type":34,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Abby Cheng","Assistant Professor",[63,66,68],{"name":64,"class":65},"National Institute of Mental Health (NIMH)","NIH",{"name":67,"class":6},"Duke University",{"name":69,"class":70},"Wysa","INDUSTRY","100591264","just-in-time-adaptive-interventions-jitais-in-a-digital-mental-health-intervention-for-middle-aged-and-older-adults-with-chronic-pain-100591264",false,"NCT06978166","Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain","Evaluating and Optimizing Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention (Wysa for Chronic Pain) for Middle-Aged and Older Adults With Chronic Pain","Inclusion Criteria:\n\n* 45 years or older\n* At least moderately severe depression and\u002For anxiety symptoms (Patient Health Questionnaire-9 (PHQ-9) and\u002For Generalized Anxiety Disorder-7 (GAD-7) score ≥ 10)\n* Chronic pain (i.e., pain on most days or every day in the past three months)\n\nExclusion Criteria:\n\n* Frequent active suicidal ideation\n* No access to a mobile device\n* Not living in the United States","ALL","45 Years",{"count":81,"type":82},1000,"ESTIMATED","INTERVENTIONAL",[85],"NA","The purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called Wysa for Chronic Pain. This app is designed to support people who have chronic pain and who also experience symptoms of depression and\u002For anxiety. This version of the app is not currently available to the public. Eligible participants will be asked to download and use the Wysa for Chronic Pain study app for several weeks, and to use it as they normally would if they were not part of a research study. At the beginning and end of the study period, participants will be asked to complete brief surveys about their mood, pain, physical function, and sleep. Additionally, a few participants will be asked to share their experience with the study app at the end of the research study in a casual interview using a secure audio\u002Fvideo recorded call. Participating in the interview portion is optional.",[88,89],"Chronic Pain","Depression, Anxiety",[91,92,93,94,95,96,97,98,99,100],"JITAI","Digital mental health intervention","Older adults","Middle-aged adults","App","Smartphone","Chronic pain","Depression","Anxiety","Chatbot","2026-04-29",{"date":103,"type":104},"2026-05-05","ACTUAL",{"date":106,"type":104},"2025-06-02",{"date":108,"type":82},"2026-12",{"name":5,"class":6},1]