[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521694":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":64,"collaborators":67,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":26,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":26,"enrollmentInfo":84,"targetDuration":26,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":96,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University of Cincinnati","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lingual Endurance Exercise","EXPERIMENTAL","The experimental exercise group will participate in 3 training sessions per day for 8 weeks. Endurance exercise will include completing isotonic endurance repetitions 3 times a day. Number of repetitions per session will be determined during baseline testing, and re-evaluated every 2 weeks, for each participant.",[13],"Behavioral: Isotonic Endurance Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Exercise","SHAM_COMPARATOR","The sham control group will be instructed to press the lingual sensor 30 times at a very low-pressure threshold (approximately 1-15 kPa), which will be monitored weekly via device output sent to the study team to avoid use of excessive force that would qualify as exercise.",[19],"Behavioral: Sham Exercise",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Isotonic Endurance Exercise","Pressing tongue against a pressure sensor at the set number of repetitions per session (individualized per participant) 3 times per day",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Pressing tongue against pressure sensor at a low threshold (1-15kPa) 30x\u002Fday",[15],[31],"Learning group",[33],{"name":34,"affiliation":5,"role":35},"Brittany N Krekeler, PhD","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Anna Hopkins, MS","CONTACT","+1 513 558 4152","hopkiak@ucmail.uc.edu",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Rebecca Reinert","+1 513 558 1719","gibsonrk@ucmail.uc.edu",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Cincinnati","Ohio","45220","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-84.51439,39.12711,{"lat":58,"lon":57},[61,62],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},{"name":63,"role":35,"phone":26,"phoneExt":26,"email":26},"Brittany Krekeler, PhD",{"type":35,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Brittany Krekeler","Assistant Professor",[68,71,73],{"name":69,"class":70},"National Institutes of Health (NIH)","NIH",{"name":72,"class":70},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",{"name":74,"class":6},"TriHealth Inc.","100521694","k01-impacts-of-lingual-endurance-exercise-100521694",false,"NCT06072924","K01 Impacts of Lingual Endurance Exercise","Impact of Lingual Endurance Exercise on Rehabilitation of Swallowing Impairments After Ischemic Stroke","Inclusion Criteria:\n\n* 1\\) 3-6 months since most recent diagnosis of ischemic, confirmed from clinical imaging) with or without small hemorrhagic transformation (HI-1)\n* 2\\) Have some indication of on-going swallowing issues\n* 3\\) English Speaking\n\nExclusion Criteria:\n\n* 1\\) ≤18 years of age\n* 2\\) history of dysphagia prior to or after the stroke caused by any of the following conditions: gastrointestinal disease, traumatic brain injury, head and neck cancer, surgery involving the pharynx or larynx\n* 3\\) history of other neurological disease (i.e. multiple sclerosis, ALS, Parkinson's, dementia).\n* 4\\) Medium to large hemorrhagic transformation\u002Finvolvement documented on clinical stroke imaging 5) 5) History of temporomandibular joint and muscle disorders (also known as TMJ).","ALL","18 Years",{"count":85,"type":86},70,"ESTIMATED","INTERVENTIONAL",[89],"NA","The goal of this clinical trial is to learn whether a tongue endurance exercise program can improve swallowing function in adults with dysphagia after a stroke. It also aims to explore how this exercise may affect brain structure and connectivity involved in swallowing. The main questions it aims to answer are:\n\nPrimary Aim: Does lingual endurance exercise improve swallowing function compared to a sham therapy? Secondary Aim: Does lingual endurance exercise lead to changes in brain structure or neuroplasticity, as measured by MRI?\n\nResearchers will compare a group receiving tongue endurance exercises to a sham therapy group to see whether the treatment improves tongue function, swallowing.\n\nParticipants will:\n\n* Complete a baseline swallowing assessment and MRI\n* Be randomly assigned to either the lingual exercise or sham therapy group\n* Complete 8 weeks of home-based tongue exercise therapy\n* Return for follow-up swallowing assessments\n* A subgroup of participants will complete a pre-treatment and post-treatment MRI.",[92,93,94,95],"Dysphagia","Dysphagia, Oropharyngeal","Ischemic Stroke","Stroke",[97,98,99],"swallowing trouble","difficulty swallowing","swallow rehab","2025-12-16",{"date":102,"type":103},"2025-12-18","ACTUAL",{"date":105,"type":103},"2023-09-01",{"date":107,"type":86},"2028-08-31",{"name":5,"class":6},1]