[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053656":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":26,"responsibleParty":60,"collaborators":25,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":29,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine (D)","EXPERIMENTAL","Patients will receive a scalp block with a 20 ml syringe containing 1 mg\u002Fkg of 0.5% bupivacaine and 1 µg\u002Fkg of dexmedetomidine, with the remainder filled with saline.",[13],"Drug: Scalp Block with Bupivacaine",{"label":15,"type":16,"description":17,"interventionNames":18},"Ketamine (K):","ACTIVE_COMPARATOR","Patients will receive a scalp block with a 20 ml syringe containing 1 mg\u002Fkg of 0.5% bupivacaine and 2 mg\u002Fkg of ketamine, with the rest filled with saline. The syringes will be prepared by an anesthesia technician and handed blindly to the anesthetist to administer the block.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Scalp Block with Bupivacaine","After induction, bilateral scalp blocks were performed using a 23G needle, with local anesthetic infiltrated around supraorbital, supratrochlear, zygomaticotemporal, auriculotemporal, lesser occipital, greater occipital, and great auricular nerves, 2-3 mL per nerve.",[9,15],null,[27,49],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Cairo university","RECRUITING","Cairo","Governorate","002","Egypt","EG",{"type":36,"coordinates":37},"Point",[38,39],31.24967,30.06263,{"lat":39,"lon":38},[42,47],{"name":43,"role":44,"phone":45,"phoneExt":25,"email":46},"Nagy Malak","CONTACT","01552480258","nagymalak12345@gmail.com",{"name":43,"role":44,"phone":45,"phoneExt":25,"email":48},"nagymalak@kasralainy.edu.eg",{"facility":50,"status":29,"city":30,"state":25,"zip":25,"country":33,"countryCode":34,"cosmosGeoPoint":51,"geoPoint":53,"contacts":54},"Cairo university Hospitals. kasralainy",{"type":36,"coordinates":52},[38,39],{"lat":39,"lon":38},[55,57,58],{"name":56,"role":44,"phone":45,"phoneExt":25,"email":46},"Nagy M Nashed, MD",{"name":25,"role":44,"phone":25,"phoneExt":25,"email":46},{"name":56,"role":59,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"type":59,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Nagy Malak , MD","Principal investigator","100053656","ketamine-versus-dexmedetomidine-as-an-adjuvant-in-scalp-block-in-supratentorial-brain-tumor-excision-surgeries-100053656",false,"NCT07698665","Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries","Efficacy of Ketamine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block in Adults Undergoing Supratentorial Brain Tumor Excision Surgeries for Hemodynamics and Pain Control, Double-blinded Randomized Study","Inclusion Criteria:\n\n* Age from 20 to 60 years, both sexes, American Society of Anesthesiologists (ASA) physical status II-III, Supratentorial tumor excision, Supine Position.\n\nand operation time: less than 6 hours.\n\nExclusion Criteria:\n\n* Patient refusal, disturbed consciousness level (Glasgow Coma Scale \\[GCS\\] \\\u003C 15). Patients who required reintubation during the study period, those not extubated. immediately after surgery, or those who awoke with neurological deficits impairing. pain assessments were excluded from the final analysis, history of psychotic disorders or previous surgeries, Poor cognitive function.\n\nPostictal state or uncontrolled\u002Frecurrent seizures, known allergy to dexmedetomidine or ketamine, difficult intubation (Mallampati score \\> III) or multiple intubation attempts, operation duration \\> 6 hours, renal dysfunction (creatinine \\> 1.2 mg\u002FdL, BUN \\> 20 mg\u002FdL), heart block and patients with chronic headache disorders or those receiving chronic analgesic therapy (for \\>3 months) were excluded.",true,"ALL","20 Years","60 Years",{"count":75,"type":76},90,"ESTIMATED","INTERVENTIONAL",[79],"NA","Supratentorial brain tumor surgeries are associated with significant nociceptive stimulation and postoperative pain, which may adversely affect patient outcomes. Scalp block has emerged as an effective regional anesthetic technique to improve analgesia and reduce opioid consumption.\n\nObjective: To compare efficacy of ketamine versus dexmedetomidine as adjuvants to bupivacaine in scalp blocks for supratentorial brain tumor surgeries, focusing on analgesia, opioid consumption, and hemodynamic stability.\n\nMethods:\n\nThis randomized double-blinded controlled trial included 80 patients undergoing supratentorial tumor excision, allocated equally into two groups: Group K received bupivacaine with ketamine (2 mg\u002Fkg), and Group D received bupivacaine with dexmedetomidine (1 µg\u002Fkg). Intraoperative hemodynamics, fentanyl consumption, postoperative pain scores (NRS), analgesic requirements, and complications were assessed.",[82,83,84],"Regional Anesthesia Morbidity","Supratentorial Brain Tumor","Acute Pain",[86,87,88],"Scalp block","Dexemetomedine","Supratentorial","2026-07-07",{"date":91,"type":92},"2026-07-13","ACTUAL",{"date":94,"type":92},"2026-01-01",{"date":96,"type":76},"2026-07-30",{"name":5,"class":6},2]