[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591839":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":33,"locations":41,"responsibleParty":58,"collaborators":60,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":12,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":12,"enrollmentInfo":76,"targetDuration":12,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":94,"overallStatus":101,"whyStopped":12,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of Maryland, College Park","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Enhanced Treatment As Usual","NO_INTERVENTION","This site will receive enhanced treatment as usual (ETAU)-a one-day training for all CHWs on mental health screening, psychoeducation on mental health in HIV and impact on HIV care outcomes, and available referral pathways, and encouraged to use these skills during their home visits.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Khanya-Ekhaya","EXPERIMENTAL","The Khanya Ekhaya intervention includes an integration of several evidence-based treatment components, including motivational interviewing (MI), problem solving therapy (PST), and behavioral activation (BA), previously tested and adapted for this context in clinic settings, as well as cognitive-behavioral and mindfulness strategies that target rumination and negative thinking patterns. Aims 1-2 will inform Khanya-Ekhaya adaptation, including intervention length, but it is likely to include 3-6 sessions of CHW home visits based on formative work with ongoing supervision and support for CHWs.",[18],"Behavioral: Khanya-Ekhaya",[20],{"type":21,"name":14,"description":16,"armGroupLabels":22,"otherNames":12},"BEHAVIORAL",[14],[24,27,30],{"name":25,"affiliation":5,"role":26},"Jessica F Magidson, PhD","PRINCIPAL_INVESTIGATOR",{"name":28,"affiliation":29,"role":26},"Tara Carney, PhD","Medical Research Council, South Africa",{"name":31,"affiliation":32,"role":26},"Bronwyn Myers, PhD","Curtin University; South African Medical Research Council",[34,38],{"name":25,"role":35,"phone":36,"phoneExt":12,"email":37},"CONTACT","301-405-5095","jmagidso@umd.edu",{"name":39,"role":35,"phone":12,"phoneExt":12,"email":40},"Abigail C Hines, MPH","ahines01@umd.edu",[42],{"facility":43,"status":12,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"South African Medical Research Council - Delft Office","Cape Town","Western Cape","7580","South Africa","ZA",{"type":50,"coordinates":51},"Point",[52,53],18.42322,-33.92584,{"lat":53,"lon":52},[56],{"name":57,"role":35,"phone":12,"phoneExt":12,"email":12},"Kim Johnson, MA",{"type":59,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[61,62,65],{"name":29,"class":6},{"name":63,"class":64},"Fogarty International Center of the National Institute of Health","NIH",{"name":66,"class":6},"Curtin University","100591839","khanya-ekhaya-a-home-based-intervention-100591839",false,"NCT06985641","Khanya Ekhaya: A Home-Based Intervention","Home-Based Community Health Worker Support for Mental Health Among People Living With HIV in South Africa: A Hybrid Effectiveness Implementation Trial","Inclusion Criteria:\n\nCHWs:\n\n* at least 18 years old\n* must conduct home visits for people with HIV newly initiating or re-initiating ART at the approved clinic site\n\nPATIENTS:\n\n* at least 18 years old\n* seen by a CHW after newly initiating or re-initiating ART in the past three months\n* screen positive for depressive symptoms or harmful alcohol use\n\nExclusion Criteria:\n\nCHWs:\n\n-Unable or unwilling to complete informed consent and study procedures in English, isiXhosa, or Afrikaans\n\nPATIENTS:\n\n-Unable or unwilling to complete informed consent and study procedures in English, isiXhosa, or Afrikaans","ALL","18 Years",{"count":77,"type":78},119,"ESTIMATED","INTERVENTIONAL",[81],"NA","Mental health conditions, such as depression, anxiety, and harmful alcohol use are prevalent among people with chronic diseases, including HIV, and contribute to poor engagement in care. There is a need to address untreated mental health problems. Community health workers (CHWs) are frontline workers who play a central role in supporting vulnerable individuals to stay in care, including seeking people living with HIV who are newly initiating antiretroviral therapy (ART) or re-initiating after a period of care disengagement. CHW-delivered interventions are promising for improving engagement and retention in care. Yet, these programs rarely address mental health -a significant barrier to chronic disease care engagement and treatment. An approach that moves beyond providing care in the clinic setting is needed. Community-delivered home-based mental health care has been shown to be feasible and acceptable and shows promise for integration into broader community health care services for people with chronic conditions, such as HIV.",[84,85,86,87,88,89,90,91,92,93],"HIV","HIV Antiretroviral Therapy (ART) Adherence","Mental Health","Substance Use Disorders","Stigma","Community Health Workers","Training","Global Health","Mental Health Recovery","Substance Use Recovery",[89,95,91,93,92,84,96,97,98,99,100,87],"Health Personnel","Health Care Seeking Behavior","Treatment Adherence and Compliance","Attitude of Health Personnel","Substance Use Stigma","Mental health Stigma","NOT_YET_RECRUITING","2025-05-14",{"date":104,"type":105},"2025-05-22","ACTUAL",{"date":107,"type":78},"2025-09-01",{"date":109,"type":78},"2026-06-15",{"name":5,"class":6},1]