[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625570":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":56,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":23,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":23,"overallStatus":39,"whyStopped":23,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Initial-Exercise'","EXPERIMENTAL","The initial exercise group will participate in an 8-week eccentric overload exercise intervention using a kBox, with two sessions per week. Participants will then cease the intervention for 8 weeks to enter a detraining period.",[13],"Other: Eccentric resistance training",{"label":15,"type":10,"description":16,"interventionNames":17},"Delayed-Exercise","The 'Delayed-Exercise' group will maintain their normal activity, without intervention, for the first 8 weeks of the study. In the second half of the study, they will begin the same 8-week kBox training completed by the 'Initial-Exercise' group.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Eccentric resistance training","The intervention consists of an eccentric overload resistance training program using a portable flywheel exercise device (kBox). This device generates resistance through inertia, meaning that the load is created by the individual's own movement speed and the effort applied. Participants with knee osteoarthritis will train with the flywheel system for 8 weeks, completing two to three sessions each week, with each session lasting approximately 30 to 45 minutes. The program will focus on functional lower-limb exercises such as squats, step-ups, and knee extensions. These exercises are chosen because they closely mimic everyday movements like climbing and descending stairs. Participants randomized to the delayed-exercise subgroup will continue with usual activity and medical care for the first 8 weeks, serving as a comparison group. After this waiting period, the delayed group will then be offered the same flywheel training protocol.",[15,9],null,[25],{"name":26,"affiliation":5,"role":27},"Michael Harris-Love, PT, MPT, DSc, FGSA, FAPTA","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":23,"email":33},"Katie Boncella, MS","CONTACT","7207241786","katie.boncella@cuanschutz.edu",{"name":26,"role":31,"phone":35,"phoneExt":23,"email":36},"303-724-0687","michael.harris-love@cuanschutz.edu",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Aurora","Colorado","80045","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-104.83192,39.72943,{"lat":49,"lon":48},[52,55],{"name":53,"role":31,"phone":54,"phoneExt":23,"email":33},"Katie Boncella","720-724-1786",{"name":26,"role":27,"phone":23,"phoneExt":23,"email":23},{"type":57,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[59],{"name":60,"class":61},"NIH\u002FNCATS Colorado CTSA Grant Number T32TR004367","UNKNOWN","100625570","knee-osteoarthritis-rehabilitation-through-rotational-inertia-100625570",false,"NCT07424352","Knee Osteoarthritis Rehabilitation Through Rotational Inertia","Exploring the Benefits of Eccentric Training for Aging Adults With Knee Osteoarthritis","KORRI","Inclusion Criteria Osteoarthritis (OA) Group:\n\n* Aged 40-70 years\n* Radiographically confirmed knee OA (Kellgren-Lawrence \\[KL\\] Grade 2 or 3)\n* Able to walk independently (assistive devices permitted)\n\nInclusion Criteria Healthy Control Group:\n\n* Aged 40-70 years\n* No radiographic evidence of knee OA (KL Grade 0 or 1)\n* No frequent knee pain\n* No history of:\n* Knee surgery (e.g., ACL reconstruction, meniscectomy, patellar realignment)\n* Significant knee injury (e.g., ligament tears, fractures, dislocations)\n* Diagnosed knee conditions (e.g., patellofemoral pain syndrome, bursitis)\n\nExclusion Criteria:\n\n* Uncontrolled hypertension or other cardiovascular disease\n* A musculoskeletal condition preventing physical testing\n* Neurological muscle weakness (e.g., stroke, spinal cord injury)\n* BMI \\>34.9 kg\u002Fm²\n* Recent hospitalization (past 3 months)",true,"ALL","40 Years","70 Years",{"count":75,"type":76},60,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.\n\nThe study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.\n\nThe hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.",[82],"Knee Arthritis, Osteoarthritis","2026-02-19",{"date":85,"type":86},"2026-02-20","ACTUAL",{"date":88,"type":86},"2025-08-20",{"date":90,"type":76},"2029-05-31",{"name":5,"class":6},1]