[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634257":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":28,"locations":27,"responsibleParty":34,"collaborators":27,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":27,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":27,"overallStatus":58,"whyStopped":27,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":27},{"fullName":5,"class":6},"Sakarya University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Genicular Nerve Thermal Radiofrequency Ablation","ACTIVE_COMPARATOR","Patients in this group will receive conventional thermal radiofrequency ablation of the superior medial, superior lateral, and inferior medial genicular nerves. The procedure will be performed at 80°C for 90 seconds per site under ultrasound guidance to achieve thermal neurocoagulation.",[13],"Other: genicular nerve block",{"label":15,"type":16,"description":17,"interventionNames":18},"Genicular Nerve Chemical Neurolysis (Alcohol)","EXPERIMENTAL","Patients will receive chemical neurolysis of the superior medial, superior lateral, and inferior medial genicular nerves. 95% ethyl alcohol (1mL per site) will be injected at the target locations to achieve chemical neurodestruction of the sensory nerves.",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"genicular nerve block","Genicular nerve radiofrequency ablation : Patients will undergo ultrasound or fluoroscopy-guided radiofrequency ablation of the genicular nerves (superior medial, superior lateral, and inferior medial). The procedure involves placing RF cannulas at the target neural sites. Once the position is confirmed by sensory and motor stimulation, thermal radiofrequency lesioning will be performed to disrupt pain signal transmission.\n\nGenicular nerve chemichal neurolysis: Patients will receive ultrasound or fluoroscopy-guided chemical neurolysis of the genicular nerves (superior medial, superior lateral, and inferior medial). Following correct needle placement confirmed by contrast spread or local anesthetic test block, a specific volume (1 mL per nerve) of ethyl alcohol (95-96% concentration) will be injected to achieve long-term neurolytic blockade of the target nerves.",[15,9],[25,26],"genicular nerve chemical neurolysis","genicular nerve radiofrequency ablation",null,[29],{"name":30,"role":31,"phone":32,"phoneExt":27,"email":33},"murat erten","CONTACT","+905435118202","muraterten37@gmail.com",{"type":35,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100634257","knee-osteoartritis-genicular-nerve-rf-ablation-vs-alcohol-neurolysis-100634257",false,"NCT07537335","Knee Osteoartritis Genicular Nerve RF Ablation vs Alcohol Neurolysis","Comparison of Genicular Nerve Radiofrequency Ablation and Neurolytic Alcohol Injection for Chronic Knee Osteoarthritis Pain: A Randomized Controlled Trial","GEN-AL-RF","Inclusion Criteria:\n\n* Age: Patients aged 45 to 85 years.\n* Diagnosis: Chronic knee pain for at least 6 months diagnosed with knee osteoarthritis according to American College of Rheumatology (ACR) criteria.\n* Radiological Grade: Grade 3 or 4 according to the Kellgren-Lawrence (K-L) classification.\n* Pain Severity: Baseline Numerical Rating Scale (NRS) score of 5 or higher.\n* Failure of Conservative Treatment: Inadequate response to conservative treatments (e.g., physical therapy, NSAIDs, or intra-articular injections) for at least 3 months.\n* Positive Diagnostic Block: At least 50% reduction in pain for minimum 24 hours following a prognostic genicular nerve block with local anesthetic.\n\nExclusion Criteria:\n\n* Previous Surgery: History of knee arthroplasty or major knee surgery on the affected side.\n* Specific Conditions: Presence of inflammatory arthritis (e.g., rheumatoid arthritis), gouty arthritis, or active infection at the injection site.\n* Neurological Deficit: Severe neurological or psychiatric disorders that may interfere with pain assessment.\n* Coagulopathy: Uncontrolled bleeding disorders or use of anticoagulant therapy that cannot be temporarily discontinued.\n* Recent Injections: Intra-articular steroid or hyaluronic acid injection within the last 3 months.\n* Allergy: Known allergy to local anesthetics, contrast agents, or ethyl alcohol.\n* Pacemaker: Presence of a cardiac pacemaker or implanted electronic device (specifically for the RFA group).","ALL","45 Years","80 Years",{"count":48,"type":49},50,"ESTIMATED","INTERVENTIONAL",[52],"NA","The GEN-AL-RF study is a randomized controlled trial designed to compare the clinical efficacy of two interventional techniques for managing chronic knee pain due to osteoarthritis. The study focuses on genicular nerve radiofrequency (RF) ablation versus neurolytic alcohol injection for pain blockade.\n\nPatients diagnosed with knee osteoarthritis are randomly assigned to either the RF ablation group or the neurolytic alcohol group. The primary objective is to evaluate the superiority and duration of analgesic effects between these two methods. Clinical outcomes are assessed at baseline and at 1, 3, and 6 months post-procedure using the Numeric Rating Scale (NRS) for pain intensity, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for physical function, and the Short Form-12 (SF-12) for health-related quality of life.\n\nThe results of this study aim to provide high-quality evidence regarding the comparative effectiveness and long-term outcomes of genicular nerve RF and alcohol neurolysis in the clinical management of chronic knee osteoarthritis pain.",[55,56,57],"Knee Osteoarthristis","Radiofrequency Ablation","NEUROLYSIS","NOT_YET_RECRUITING","2026-04-10",{"date":61,"type":62},"2026-04-17","ACTUAL",{"date":64,"type":49},"2026-05-01",{"date":66,"type":49},"2026-12-30",{"name":5,"class":6}]