[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605499":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":17,"locations":7,"responsibleParty":23,"collaborators":7,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":29,"sex":35,"minAge":36,"maxAge":37,"enrollmentInfo":38,"targetDuration":41,"studyType":42,"phases":7,"briefSummary":43,"conditions":44,"keywords":7,"overallStatus":49,"whyStopped":7,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":7},{"fullName":5,"class":6},"Chengdu University of Traditional Chinese Medicine","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"PROCEDURE","Endovenous Ablation for Varicose Veins","Participants will receive standard endovenous treatment for lower limb varicose veins as part of their routine clinical care. The procedure may include radiofrequency ablation (RFA), endovenous laser ablation (EVLA), or other accepted thermal ablation techniques, with or without adjunctive phlebectomy or foam sclerotherapy if clinically indicated. The intervention is performed under tumescent local anesthesia by vascular surgeons according to established guidelines. No experimental techniques or investigational devices are used.",[14,15,16],"Endovenous Thermal Ablation (Radiofrequency Ablation or Endovenous Laser Ablation)","Endovenous Treatment for Varicose Veins","Standard Varicose Vein Surgery",[18],{"name":19,"role":20,"phone":21,"phoneExt":7,"email":22},"Chunshui He, Doctor","CONTACT","18981885601","Chunshuihe@msn.com",{"type":24,"investigatorFullName":25,"investigatorTitle":26,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Chunshui He","Ph.D , Chief Physician of Vascular Surgery , Hospital of Chengdu University of Traditional Chinese Medicine","100605499","knee-pain-relief-after-endovenous-treatment-for-lower-limb-varicose-veins-a-prospective-observational-study-100605499",false,"NCT07163312","Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study","Prospective Observational Cohort Study of Knee Pain and Function After Endovenous Treatment for Lower Limb Varicose Veins","VV-KNEE","Inclusion Criteria:\n\nAdults aged ≥18 years. Clinical diagnosis of lower limb varicose veins with documented venous reflux on duplex ultrasound (CEAP C2-C4).\n\nPresence of knee pain lasting ≥4 weeks prior to enrollment, confirmed by patient-reported VAS\u002FNRS ≥3 at baseline.\n\nPlanned to undergo standard endovenous treatment (radiofrequency ablation, endovenous laser ablation, or equivalent).\n\nAbility to provide informed consent and complete study questionnaires.\n\nExclusion Criteria:\n\nPrior surgery or endovenous ablation for varicose veins in the same limb. History of inflammatory arthritis (e.g., rheumatoid arthritis, gout) or other systemic rheumatologic disease.\n\nRecent acute knee injury (ligament, meniscus, fracture) within 6 months. Prior knee replacement or major knee surgery. Recent intra-articular injection or arthroscopy (\\\u003C3 months). Known deep vein thrombosis or history of pulmonary embolism within the past 6 months.\n\nSevere peripheral arterial disease (ABI \\\u003C0.8). Pregnancy or breastfeeding. Inability to comply with follow-up schedule or complete questionnaires.","ALL","18 Years","80 Years",{"count":39,"type":40},50,"ESTIMATED","6 Months","OBSERVATIONAL","This study will observe patients with lower limb varicose veins who also have knee pain. Many patients with varicose veins experience swelling, heaviness, or aching in the legs, and some also report pain in or around the knee. Previous studies suggest that venous reflux and poor circulation may increase discomfort in the knee, especially when knee osteoarthritis is present.\n\nThe purpose of this study is to evaluate whether treatment of varicose veins with standard endovenous procedures can improve knee pain and function. Participants will undergo standard vein treatment as part of their clinical care. We will follow them for changes in knee pain, quality of life, and leg symptoms over time.\n\nThis study does not assign patients to experimental interventions. Instead, it collects information before and after treatment to better understand the relationship between varicose veins and knee pain relief. Findings from this study may help doctors identify which patients are most likely to benefit from venous treatment in terms of both leg and knee symptoms.",[45,46,47,48],"Varicose Veins of Lower Limb","Chronic Venous Insufficiency, CVI","Knee Pain Chronic","Knee Osteoarthritis","NOT_YET_RECRUITING","2025-09-01",{"date":52,"type":53},"2025-09-09","ACTUAL",{"date":55,"type":40},"2025-10-01",{"date":57,"type":40},"2026-11-01",{"name":5,"class":6}]