[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628795":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":41,"locations":47,"responsibleParty":62,"collaborators":66,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":32,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":97,"overallStatus":50,"whyStopped":32,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"University of Vienna","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"L-serine and strength training","EXPERIMENTAL","The L-serine and training group (LSERTRAIN) receives an L-serine supplement at a dose of 6 g\u002Fday over the entire study period (48 weeks).",[13,14],"Behavioral: Strength training","Dietary Supplement: L-serine supplementation",{"label":16,"type":17,"description":18,"interventionNames":19},"L-serine supplementation","ACTIVE_COMPARATOR","The L-serine group (LSER) receives an L-serine supplement at a dose of 6 g\u002Fday over the entire study period (48 weeks).",[14],{"label":21,"type":22,"description":23,"interventionNames":24},"Control","PLACEBO_COMPARATOR","The control group (PLA) receives a placebo (cornstarch) throughout the entire study period (48 weeks)",[25],"Dietary Supplement: Control (cornstarch)",[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"BEHAVIORAL","Strength training","Structured strength training 2x\u002Fweek",[9],null,{"type":34,"name":16,"description":35,"armGroupLabels":36,"otherNames":32},"DIETARY_SUPPLEMENT","L-serine supplementation 6g\u002Fday",[9,16],{"type":34,"name":38,"description":39,"armGroupLabels":40,"otherNames":32},"Control (cornstarch)","Placebo 6g cornstarch\u002Fday, No strength training",[21],[42],{"name":43,"role":44,"phone":45,"phoneExt":32,"email":46},"Karl-Heinz Wagner, Prof.","CONTACT","+43-1-4277-54930","karl-heinz.wagner@univie.ac.at",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":32},"NuTraLab","RECRUITING","Vienna","State of Vienna","1070","Austria","AT",{"type":57,"coordinates":58},"Point",[59,60],16.37208,48.20849,{"lat":60,"lon":59},{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Karl-Heinz Wagner","Univ.-Prof. Dr.",[67],{"name":68,"class":6},"Medical University of Vienna","100628795","l-serine-and-strength-training-in-the-elderly-100628795",false,"NCT07466290","L-serine and Strength Training in the Elderly","AAAging","Inclusion Criteria:\n\n* Men and women between the ages of 65 and 85\n* Mini-Mental-State \\>23\n* Independently mobile, without aids (walker, cane, etc.)\n\nExclusion Criteria:\n\n* Chronic diseases that contraindicate medical training therapy\n* Regular strength training (\\>1x\u002Fweek) in the last 6 months before confinement\n* Frailty Index ≥ 3\n* Lack of written consent to test physical performance\n* Regular use of Cortison-containing medications or Antibiotika\n* MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body\n* Non-compliance with the study protocol: \\\u003C70% of the planned L-serine administration, \\\u003C70% of the strength training",true,"ALL","65 Years","85 Years",{"count":81,"type":82},126,"ESTIMATED","INTERVENTIONAL",[85],"NA","This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people.\n\nHealthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training.\n\nCognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.",[88,89,90,91,92,93,94,95,96],"Brain Health","Longevity","Cognitive Performance","Strength Training Effects","Healthy Ageing","Ageing","Cognition","Memory","Muscle Strength",[92,98,99,16,100,101,102,95,103,104,105,106,107,108],"Brain ageing","Older adults","Resistance training","Cognitive function","Cognitive ageing","Hippocampus","Magnetic resonance imaging","Electroencephalography","Brain connectivity","Muscle strength","Synaptic plasticity","2026-03-06",{"date":111,"type":112},"2026-03-12","ACTUAL",{"date":114,"type":82},"2026-03",{"date":116,"type":82},"2028-12",{"name":5,"class":6},1]