[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630523":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":31,"responsibleParty":45,"collaborators":20,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":20,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":20,"enrollmentInfo":56,"targetDuration":20,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":67,"whyStopped":20,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Yale University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"fMRI neurofeedback (NF) and Glioma","EXPERIMENTAL","All participants will receive an fMRI NF intervention delivered as a presurgical prehabilitation strategy involving eloquent language cortex. The intervention will be conducted during the standard preoperative window and will not alter or delay clinical care. The study involves repeated within-subject assessments, including baseline and post-intervention neuropsychological testing and task-based fMRI measures.",[13],"Device: fMRI",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","fMRI","Real-time functional magnetic resonance imaging (fMRI) neurofeedback (NF)",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Luca Pasquini, MD, PhD","Yale School of Medicin","PRINCIPAL_INVESTIGATOR",[27],{"name":23,"role":28,"phone":29,"phoneExt":20,"email":30},"CONTACT","203-688-2433","luca.pasquini@yale.edu",[32],{"facility":33,"status":20,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":20},"Yale School of Medicine","New Haven","Connecticut","06520","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-72.92816,41.30815,{"lat":43,"lon":42},{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100630523","language-network-prehab-via-fmri-neurofeedback-100630523",false,"NCT07488780","Language Network Prehab Via fMRI Neurofeedback","fMRI Neurofeedback for Prehabilitation of the Language Network in Patients Undergoing Radical Glioma Surgery","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Diagnosis of WHO grade II-III glioma involving eloquent language cortex\n* Scheduled for surgical resection\n* MRI-compatible\n* Ability to perform the simple language tasks required for fMRI and neurofeedback\n* Residence within 2 hours of Yale MRRC and ability and willingness to make multiple visits for study participation\n\nExclusion Criteria:\n\n* Severe baseline aphasia precluding task performance\n* Contraindications to MRI\n* Significant cognitive\u002Fpsychiatric comorbidity limiting compliance\n* Concurrent enrollment in other interventional trials\n* Claustrophobia of a degree that they cannot comfortably be scanned\n* Inability or unwillingness to understand or follow the instructions\n* Pregnancy or possible pregnancy","ALL","18 Years",{"count":57,"type":58},4,"ESTIMATED","INTERVENTIONAL",[61],"NA","This is an interventional neuroimaging study that will examine whether fMRI neurofeedback can shift language network activity away from regions affected by glioma prior to surgery.",[64,65],"Glioma","Glioma Surgery",[17],"NOT_YET_RECRUITING","2026-03-17",{"date":70,"type":71},"2026-03-23","ACTUAL",{"date":73,"type":58},"2026-04",{"date":75,"type":58},"2026-12",{"name":5,"class":6},1]