[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629972":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":10,"responsibleParty":33,"collaborators":10,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":10,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":56,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":10},{"fullName":5,"class":6},"Northwestern University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Laparoscopic Sclerotherapy",null,"Patients who choose to undergo laparoscopic sclerotherapy for management of their ovarian endometrioma.",[13],"Procedure: Laparoscopic sclerotherapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Laparoscopic sclerotherapy","Standard of care for an endometrioma is a laparoscopic cystectomy. This procedure still uses laparoscopy however instead of a cystectomy, the ovarian cyst is drained and ethanol is instilled for sclerotherapy and then removed from the cyst. The benefit is hopefully a lesser impact on ovarian reserve as opposed to ovarian cystectomy.",[9],[21],{"name":22,"affiliation":5,"role":23},"Magdy Milad, MD","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Hannah Pope, MD","CONTACT","3126946773","hannah.pope@nm.org",{"name":31,"role":27,"phone":10,"phoneExt":10,"email":32},"Juan Avitia, MPH","juan.avitia1@nm.org",{"type":23,"investigatorFullName":22,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Albert B Gerbie Professor","100629972","laparoscopic-sclerotherapy-for-the-management-of-ovarian-endometriomas-100629972",false,"NCT07481617","Laparoscopic Sclerotherapy for the Management of Ovarian Endometriomas","Laparoscopic Sclerotherapy for Management of Endometriomas: A Pilot Study Evaluating Impact on Ovarian Reserve","Inclusion Criteria:\n\n* English speaking\n* Age of 18 or greater\n* At least one ovarian endometrioma \\> 4 cm in size\n* Desires to proceed with surgical management of the endometrioma\n\nExclusion Criteria:\n\n* Known diminished ovarian reserve (AMH \\\u003C 1.0)\n* Known allergies to ethanol solutions\n* Pregnancy","FEMALE","18 Years","55 Years",{"count":46,"type":47},20,"ESTIMATED","6 Weeks","OBSERVATIONAL","The objective of this study is to evaluate the effect of laparoscopic sclerotherapy on ovarian reserve and its overall efficacy in the treatment of endometriomas. Ovarian reserve will be assessed using preoperative and postoperative anti-Müllerian hormone (AMH) levels and antral follicle count (AFC). Traditionally, ovarian endometriomas are managed by complete cystectomy; however, multiple studies including a large systematic review and meta-analysis-have demonstrated that cystectomy significantly reduces ovarian reserve, with an average decline in AMH of 1.77 ng\u002FmL within one to six weeks postoperatively without recovery to baseline after many months. Sclerotherapy has historically been a potential alternative, typically performed by interventional radiology via transvaginal, transabdominal, or transgluteal drainage. This percutaneous approach, however, precludes direct visualization of the cyst and surgical management of concurrent conditions including endometriosis peritoneal disease, excision, adhesions, or tubal disease.\n\nSeveral studies have explored the feasibility and effectiveness of laparoscopic sclerotherapy, reporting encouraging results regarding its safety, increased AFC compared with cystectomy, and comparable pregnancy rates. Nonetheless, none of these studies have been conducted in the United States, and few have utilized a laparoscopic approach. Further research is therefore warranted to establish the accessibility and reproducibility of this technique. The investigators aim to conduct the first U.S.-based study evaluating the impact of laparoscopic sclerotherapy on ovarian reserve. The primary outcome will be the change in AMH and AFC at six weeks postoperatively. Consistent with prior evidence, the investigators hypothesize that laparoscopic sclerotherapy will result in a smaller decline in ovarian reserve compared with traditional cystectomy.",[52,53,54,55],"Endometriosis","Endometrioma","Sclerotherapy","Laparoscopy",[57],"laparoscopic sclerotherapy","NOT_YET_RECRUITING","2026-04-23",{"date":61,"type":62},"2026-04-29","ACTUAL",{"date":64,"type":47},"2026-05-16",{"date":66,"type":47},"2027-08-30",{"name":5,"class":6}]