[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547267":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":34,"responsibleParty":50,"collaborators":54,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":19,"enrollmentInfo":68,"targetDuration":19,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University Hospital Bispebjerg and Frederiksberg","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"LAA closure","All patients included in the study undergo closure of the Left Atrial Appendage",[12],"Procedure: left atrial appendage closure",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","left atrial appendage closure","systematic closure of the left atrial appendage in addition to the planned heart surgery",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Helena Dominguez","STUDY_DIRECTOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Helena DOMINGUEZ, MD, PhD","CONTACT","4522989343","mdom0002@regionh.dk",{"name":31,"role":27,"phone":32,"phoneExt":19,"email":33},"Ida Gustafsson, MD, PhD","4538635000","ida.gustafsson@regionh.dk",[35],{"facility":36,"status":37,"city":38,"state":19,"zip":19,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Rigshospitalet","RECRUITING","Copenhagen","Denmark","DK",{"type":42,"coordinates":43},"Point",[44,45],12.56553,55.67594,{"lat":45,"lon":44},[48],{"name":49,"role":27,"phone":19,"phoneExt":19,"email":19},"Christian L Carranza",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Helena DOMINGUEZ","MD, PhD, Associate Professor",[55,57],{"name":56,"class":6},"Rigshospitalet, Denmark",{"name":58,"class":6},"University of Copenhagen","100547267","left-atrial-appendage-arrhythmogenic-and-thrombogenic-substrate-100547267",false,"NCT06405750","Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate","LAATAS","Inclusion Criteria:\n\n* signed informed consent AND\n* planned any open-heart surgery:\n\n  * CABG\n  * valve repair or replacement\n  * aorta surgery\n  * any combination of the above\n\nExclusion Criteria:\n\n* current endocarditis\n* follow-up not possible","ALL","18 Years",{"count":69,"type":70},1000,"ESTIMATED","INTERVENTIONAL",[73],"NA","The purpose of the project is to elucidate whether it is possible to identify which patients are at risk of forming blood clots that can cause stroke based on analysis of the electrocardiogram.\n\nIn connection with the operation, the small pouch known as the auricle of the heart is closed, which can be completely removed after closing. This procedure is common in patients with atrial fibrillation to protect the brain from stroke. In the project, all patients will have this auricle closed if they agree to participate in the project.\n\nAfter closure, the auricle is usually discarded. We will analyze the blood and the auricle tissue taken (if available) in connection with the operation itself, together with the analysis of the electrocardiogram recorded before the planned heart operation.",[76,77],"Atrial Fibrillation","Stroke",[79,80,81,82,83,84,85],"heart surgery","atrial myocardiopathy","arrhythmogenic substrate","stroke","cerebral transitory ischemic attack","thrombogenesis","cardiac embolism","2026-01-14",{"date":88,"type":89},"2026-01-15","ACTUAL",{"date":91,"type":89},"2024-08-01",{"date":93,"type":70},"2035-12-31",{"name":5,"class":6},1]