[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628622":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":88,"collaborators":26,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":94,"sex":100,"minAge":101,"maxAge":26,"enrollmentInfo":102,"targetDuration":26,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":26,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Left bundle branch area pacing","EXPERIMENTAL","Left bundle branch area pacing performed using a stylet-driven extendable screw-in lead for treatment of atrioventricular block.",[13],"Device: Left Bundle Branch Area Pacing",{"label":15,"type":16,"description":17,"interventionNames":18},"Right ventricular pacing","ACTIVE_COMPARATOR","Conventional right ventricular pacing using a transvenous pacing lead for treatment of atrioventricular block.",[19],"Device: Right venticular pacing",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Left Bundle Branch Area Pacing","Left bundle branch area pacing performed using a stylet-driven extendable screw-in pacing lead to achieve physiological ventricular activation in patients with atrioventricular block.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Right venticular pacing","Conventional right ventricular pacing performed with a standard transvenous pacing lead for treatment of atrioventricular block.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Seung-Jung Park, MD, PhD","CONTACT","82-2-3410-3419","orthovics@gmail.com",[38,55,65,78],{"facility":39,"status":40,"city":41,"state":42,"zip":26,"country":43,"countryCode":26,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Wonju Severance Christian Hospital","RECRUITING","Wŏnju","Gangwon-do","South Korea",{"type":45,"coordinates":46},"Point",[47,48],127.94528,37.35139,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":53,"phoneExt":26,"email":54},"Young Jun Park, MD","82-10-9842-0369","pyj@yonsei.ac.kr",{"facility":5,"status":40,"city":56,"state":56,"zip":57,"country":43,"countryCode":26,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Seoul","06351",{"type":45,"coordinates":59},[60,61],126.9784,37.566,{"lat":61,"lon":60},[64],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"facility":66,"status":40,"city":67,"state":26,"zip":26,"country":43,"countryCode":26,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Samsung Changwon Hospital","Changwon",{"type":45,"coordinates":69},[70,71],128.68111,35.22806,{"lat":71,"lon":70},[74],{"name":75,"role":34,"phone":76,"phoneExt":26,"email":77},"Hye Bin Gwag, MD","82-10-4761-9395","tgfbk@naver.com",{"facility":79,"status":40,"city":56,"state":26,"zip":26,"country":43,"countryCode":26,"cosmosGeoPoint":80,"geoPoint":82,"contacts":83},"Veterans Health Service Medical Center",{"type":45,"coordinates":81},[60,61],{"lat":61,"lon":60},[84],{"name":85,"role":34,"phone":86,"phoneExt":26,"email":87},"Jin Kyung Hwang, MD","82-10-8870-0768","dangtong@naver.com",{"type":89,"investigatorFullName":90,"investigatorTitle":91,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Seung-Jung Park","MD, PhD","100628622","left-bundle-branch-area-pacing-versus-right-ventricular-pacing-in-atrioventricular-block-with-preserved-ejection-fraction-100628622",false,"NCT07464041","Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Atrioventricular Block With Preserved Ejection Fraction","Left Bundle Branch Area Pacing With a Stylet-Driven Lead Versus Right Ventricular Pacing in Patients With Atrioventricular Block and Preserved Ejection Fraction: A Multicenter Randomized Trial","NOVEL II","Inclusion Criteria:\n\nPatients requiring permanent pacemaker implantation for the following indications:\n\n* Third-degree AV block\n* First- or second-degree AV block with an expected ventricular pacing burden ≥40%\n* Atrial fibrillation with slow ventricular response with an expected ventricular pacing burden ≥40%\n\nExclusion Criteria:\n\n* Prior implantation of a cardiac pacemaker or implantable cardioverter-defibrillator\n* Left ventricular ejection fraction ≤50%\n* Indication for cardiac resynchronization therapy\n* Life expectancy ≤1 year (e.g., patients not eligible for heart transplantation due to end-stage heart failure, patients with DNR orders, those receiving hospice care after refusal of life-sustaining treatment, or patients with terminal cancer not eligible for chemotherapy or radiotherapy)","ALL","19 Years",{"count":103,"type":104},200,"ESTIMATED","INTERVENTIONAL",[107],"NA","Conventional right ventricular pacing (RVP) has been associated with ventricular dyssynchrony and an increased risk of pacing-induced cardiomyopathy, which may lead to worse clinical outcomes. These adverse effects are more pronounced in patients with pre-existing left ventricular dysfunction. To overcome these limitations, left bundle branch area pacing (LBBAP), which directly engages the cardiac conduction system to preserve physiological ventricular activation, has been increasingly adopted in clinical practice.\n\nHowever, in patients with atrioventricular block and preserved left ventricular ejection fraction (LVEF ≥50%), evidence demonstrating the long-term clinical superiority of LBBAP over conventional RVP remains limited. As a result, both pacing strategies continue to be used in current practice. This multicenter randomized trial aims to compare the efficacy, safety, and lead stability of LBBAP using a stylet-driven extendable screw-in lead versus conventional RVP in patients with atrioventricular block and preserved ejection fraction.",[110,111,112],"Atrioventricular Block","Left Bunde Branch Area Pacing","Conduction System Pacing","2026-03-06",{"date":115,"type":116},"2026-03-11","ACTUAL",{"date":118,"type":116},"2024-04-29",{"date":120,"type":104},"2027-06-30",{"name":5,"class":6},4]