[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100225115":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":42,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":10,"maxAge":10,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Leipzig","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"lean and obese children and adolescents",null,"study cohort may be stratified for lean (definded as BMI \\\u003C1.28 SDS) and overweight\u002Fobese (definded as BMI\\>= 1.28 SDS) children for posthoc analyses no intervention",[13],{"name":14,"affiliation":5,"role":15},"Antje Körner, Prof. Dr.","PRINCIPAL_INVESTIGATOR",[17,21],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","0049\u002F(0)341-9726854","Antje.Koerner@medizin.uni-leipzig.de",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Robert Stein, MD","0049\u002F(0)341-9726537","Robert.stein@medizin.uni-leipzig.de",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Center for Pediatric Research Leipzig (CPL)","RECRUITING","Leipzig","Saxony","04103","Germany","DE",{"type":35,"coordinates":36},"Point",[37,38],12.37129,51.33962,{"lat":38,"lon":37},[41],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":15,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Antje Koerner, Prof. Dr. med.","Prof. Dr. med.","100225115","leipzig-adipose-tissue-childhood-cohort-100225115",false,"NCT02208141","Leipzig Adipose Tissue Childhood Cohort","Determinants of Adipose Tissue Development and Obesity in Children and Adolescents","Inclusion Criteria:\n\n* body weight: 3000 g - 180 kg\n* suitable surgical procedure\n* signed informed consent by the guardians and the study participant, if older 12 years\n\nExclusion Criteria:\n\n* severe chronic and inflammatory diseases\n* acute or chronic infections\n* oncological diseases\n* clotting disorders\n* complications during surgical procedure\n* drug treatment\n* nil by mouth",true,"ALL",{"count":55,"type":56},1000,"ESTIMATED","OBSERVATIONAL","In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents. The investigators aim to identify and characterize mechanisms and molecular targets that affect the development of adipose tissue and ensuing obesity in childhood and adolescence.",[60,61],"Childhood Obesity","Insulin Resistance",[63,64,65,66,67,68,69],"children","obesity","adipose tissue dysfunction","inflammation","macrophage infiltration","insulin resistance","dyslipidemia","2023-11-03",{"date":72,"type":73},"2023-11-07","ACTUAL",{"date":75,"type":10},"2010-10",{"date":77,"type":56},"2030-12",{"name":5,"class":6},1]