[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574606":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":38,"responsibleParty":59,"collaborators":18,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":18,"maxAge":18,"enrollmentInfo":72,"targetDuration":18,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Hospital Alemão Oswaldo Cruz","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Multifaceted intervention","EXPERIMENTAL","Implementation of active-case finding strategies",[13],"Other: Implementing active-case finding strategies",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care","NO_INTERVENTION","Routine screening",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Implementing active-case finding strategies","Implementation of a multifactorial active-case finding strategy, including: (1) raising awareness among the population about leprosy; (2) theoretical and practical educational training for healthcare workers; (3) georeferencing of historical and existing cases in the municipality (from 2012 to 2023) and of new cases diagnosed throughout the study (dynamic changes); (4) screening tools for signs\u002Fsymptoms of the disease (application of Leprosy Suspicion Questionnaire); and (5) serological profile (rapid test) of patients with reported signs\u002Fsymptoms (positive answers Leprosy Suspicion Questionnaire).",[9],[25],{"name":26,"affiliation":5,"role":27},"Rosa C Lucchetta, PhD","STUDY_DIRECTOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Sebastian A Vernal, MD, PhD","CONTACT","+61 488 062 931","vernal.carranza@gmail.com",{"name":35,"role":31,"phone":36,"phoneExt":18,"email":37},"Katia C Braz","+55 11 99616 5496","katia.braz@haoc.com.br",[39],{"facility":5,"status":40,"city":41,"state":18,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","São Paulo","01327-001","Brazil","BR",{"type":46,"coordinates":47},"Point",[48,49],-46.63611,-23.5475,{"lat":49,"lon":48},[52,53,57],{"name":35,"role":31,"phone":36,"phoneExt":18,"email":37},{"name":54,"role":31,"phone":55,"phoneExt":18,"email":56},"Gisele S Belber","+55 11 94968 8725","gisele.belber@haoc.com.br",{"name":30,"role":58,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"type":58,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Sebastian Andres Vernal Carranza","Medical Doctor","100574606","leprosy-active-searching-trial-in-brazil-100574606",false,"NCT06761469","Leprosy Active Searching Trial in Brazil","Pragmatic, Randomized, Cluster Stepped-Wedge Clinical Trial for Active Case Finding of Leprosy in Brazil","LAST•Br","Inclusion Criteria:\n\n(I) Municipalities\n\n* Municipality recognized by the Brazilian Institute of Geography and Statistics as part of the Brazilian Federation.\n* Municipality with operational epidemiological classification by the Ministry of Health (BMoH) as: 'municipalities with cases in the period from 2015 to 2019'.\n* Municipality with authorization\u002Fconsent from the government to participate in the study.\n\n(II) Primary Health Units (Unidade Básica de Saúde or UBS) • UBS with territorial coverage (linked population) within the participating municipality.\n\n(III) Participants\n\n• Patients with positive Leprosy Suspicion Questionnaire (LSQ): children under five years old with Free and Informed Consent Form (ICF) signed by parents\u002Fguardians, 5-17 years old with ICF signed by parents\u002Fguardians and Free and Informed Assent Form (IAF) signed by the minor, and patients over 18 years old with ICF signed for: rapid test collection, comorbidity questionnaire and clinical evaluation; and if leprosy diagnosis is confirmed, collection of complementary exams.\n\nExclusion Criteria:\n\n(I) Municipalities\n\n* Municipality with extreme population size (municipalities with a number of inhabitants lower than the 10th percentile and higher than the 90th percentile).\n* Municipality with operational epidemiological classification by the BMoH as: 'municipalities without cases in the period 2015 to 2019'.\n* Municipalities with active or recent participation (less than one year) in other active-finding strategies, in addition to the usual ones: ministerial, Non-Governmental Organizations (NGOs), academic, among others.\n\n(II) Primary Health Units\n\n* UBS with limited multidisciplinary team (absence of physicians, nurse and\u002For community health agents).\n* UBS with difficult access (no access by land, i.e. riverside populations).\n* UBS with territorial coverage exclusively of indigenous populations.\n\n(III) Participants\n\n* LSQ negative.\n* Patients with a previous diagnosis or history of treated leprosy.\n* Patients residing\u002Fregistered outside the selected municipality.",true,"ALL",{"count":73,"type":74},1925,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to assess whether a multifactorial active case-finding strategy improves the detection of leprosy cases in Brazil compared to usual screening practices. The main questions it aims to answer are:\n\n\\- Does the intervention increase the number of new leprosy cases detected compared to standard care?\n\nParticipants will:\n\n* Receive community awareness about leprosy.\n* Be screened using the Leprosy Suspicion Questionnaire at priority areas identified by georeference tools.\n* Undergo clinical evaluation by a trained medical team.\n* If leprosy is diagnosed, affected patients will collect complementary laboratory exams\n\nHealthcare professionals from primary care units will receive training in leprosy, while researchers will monitor changes in leprosy incidence over a 12-month period using data from Brazil's national notification system. The study will provide insights into underdiagnosis and the clinical profiles of patients who have been diagnosed.",[80],"Leprosy",[80,82,83,84,43],"Active-case finding","Cluster stepped-wedge","Clinical trial","2026-04-26",{"date":87,"type":88},"2026-04-28","ACTUAL",{"date":90,"type":88},"2025-06-01",{"date":92,"type":74},"2026-05-31",{"name":5,"class":6},1]