[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100384666":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":41,"locations":48,"responsibleParty":65,"collaborators":10,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":10,"maxAge":10,"enrollmentInfo":76,"targetDuration":10,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":10,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Cologne","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Leptospirosis group",null,"Patients with cultural, serological, molecular or histological evidence and clinical evidence of invasive leptospirosis disease.",[13,14,15],"Other: Retrospective data collection of demographics","Other: Retrospective data collection of underlying diseases","Other: Retrospective data collection of duration of hospitalization",{"label":17,"type":10,"description":18,"interventionNames":19},"Control group","Controls will be included at the same hospitals that conduced cases based on matching of demographics, underlying diseases and duration of hospitalization (i.e. one control per case, both in the same hospital)",[13,14,15],[21,25,29],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Retrospective data collection of demographics","Retrospective data collection of demographics from patients with leptospirosis and matching control group patients.",[17,9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Retrospective data collection of underlying diseases","Retrospective data collection of underlying diseases from patients with leptospirosis and matching control group patients.",[17,9],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"Retrospective data collection of duration of hospitalization","Retrospective data collection of duration of hospitalization from patients with leptospirosis and matching control group patients.",[17,9],[34,38],{"name":35,"affiliation":36,"role":37},"Volker Burst, MD","University Hospital of Cologne","STUDY_CHAIR",{"name":39,"affiliation":36,"role":40},"Felix Köhler, MD","PRINCIPAL_INVESTIGATOR",[42,46],{"name":39,"role":43,"phone":44,"phoneExt":10,"email":45},"CONTACT","+4922147897222","felix.koehler@uk-koeln.de",{"name":39,"role":43,"phone":10,"phoneExt":10,"email":47},"kidneyinfection@uk-koeln.de",[49],{"facility":36,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Cologne","North Rhine-Westphalia","50937","Germany","DE",{"type":57,"coordinates":58},"Point",[59,60],6.95,50.93333,{"lat":60,"lon":59},[63,64],{"name":39,"role":43,"phone":10,"phoneExt":10,"email":45},{"name":39,"role":43,"phone":10,"phoneExt":10,"email":47},{"type":40,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Volker Burst","Principal Investigator","100384666","leptospirosis-registry---leptoscope-100384666",false,"NCT04288674","Leptospirosis Registry - LeptoScope","Leptoscope","Inclusion Criteria:\n\n* Cultural, serological, molecular or histological evidence of invasive leptospirosis diseases\n* Clinical signs of disseminated leptospirosis disease without cultural, serological, molecular or histological evidence\n* Case controls: Matching procedures for controls: Particularly, case controls will be included at the same hospitals that conduced cases based on matching of demographics, underlying diseases and duration of hospitalization (i.e. one control per case, both in the same hospital).\n\nExclusion Criteria:\n\n* Colonization or other non-invasive infection\n* Cultural, serological, molecular or histological evidence without dissemination","ALL",{"count":77,"type":78},200,"ESTIMATED","OBSERVATIONAL","Leptospirosis is a worldwide zoonotic diseases caused by pathogenic Leptospira spp. Human are accidental hosts, who acquired infections after exposition to animal urine, contaminated water or soil, infected tissue. Incidence of invasive leptospirosis disease causing acute kidney injury, acute respiratory distress syndrome (ARDS), myocarditis, hepatic dysfunction, hemorrhage and multi-organ failure, is globally increasing and there have been frequent outbreak situation throughout the world. Due to increasing outbreak situations and globally chances in species distributions, a worldwide surveillance in epidemiology and species distribution is urgently needed. The objective of the Leptospirosis Registry - LeptoScope is to overcome the lack knowledge on epidemiology, clinical course, prognostic factors and molecular characteristics for invasive leptospirosis disease.",[82],"Leptospirosis","2025-12-09",{"date":85,"type":86},"2025-12-17","ACTUAL",{"date":88,"type":86},"2020-03-04",{"date":90,"type":78},"2030-12",{"name":5,"class":6},1]