[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548285":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":134,"collaborators":25,"id":136,"slug":137,"hasResults":138,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":138,"sex":144,"minAge":145,"maxAge":25,"enrollmentInfo":146,"targetDuration":25,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":161,"whyStopped":25,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","EXPERIMENTAL","Patients will benefit from surgery with the use of L-PRF.",[13],"Procedure: Surgery with the use of L-PRF",{"label":15,"type":6,"description":16,"interventionNames":17},"Control group","Patients will benefit from standard surgical treatment.",[18],"Procedure: Standard surgery",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Surgery with the use of L-PRF","The study protocol is the same as the standard surgery one but with additional use of L-PRF membranes",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard surgery","The standard surgical treatment, taking place in the operating room under general anesthesia",[15],[31],{"name":32,"affiliation":5,"role":33},"Claire VILLEPINTE, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Franck DELANOË, MD","CONTACT","+33 5 61 77 74 76","delanoe.f@chu-toulouse.fr",[41,59,69,83,97,111,124],{"facility":42,"status":25,"city":43,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"University Hospital - Centre François-Xavier Michelet","Bordeaux","France","FR",{"type":47,"coordinates":48},"Point",[49,50],-0.58046,44.84124,{"lat":50,"lon":49},[53,58],{"name":54,"role":37,"phone":55,"phoneExt":56,"email":57},"Mathieu BONDAZ, MD","05 56 79 56 79","+33","mathieu.bondaz@chu-bordeaux.fr",{"name":54,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":60,"status":25,"city":43,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":61,"geoPoint":63,"contacts":64},"University Hospital - Groupe hospitalier Pellegrin",{"type":47,"coordinates":62},[49,50],{"lat":50,"lon":49},[65,68],{"name":66,"role":37,"phone":55,"phoneExt":56,"email":67},"Jean-Christophe FRICAIN, MD","jean-christophe.fricain@u-bordeaux.fr",{"name":66,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":70,"status":25,"city":71,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"University Hospital","Limoges",{"type":47,"coordinates":73},[74,75],1.24759,45.83362,{"lat":75,"lon":74},[78,82],{"name":79,"role":37,"phone":80,"phoneExt":56,"email":81},"Julie USSEGLIO, MD","05 55 05 61 20","julie.usseglio@chu-limoges.fr",{"name":79,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":84,"status":25,"city":85,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"University Hospital Gui de CHAULIAC","Montpellier",{"type":47,"coordinates":87},[88,89],3.87635,43.61093,{"lat":89,"lon":88},[92,96],{"name":93,"role":37,"phone":94,"phoneExt":56,"email":95},"Marie DE BOUTRAY, MD","04 67 33 68 03","m-deboutray@chu-montpellier.fr",{"name":93,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":98,"status":25,"city":99,"state":25,"zip":100,"country":44,"countryCode":45,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"University Hospital Pitié-Salpêtrière","Paris","75013",{"type":47,"coordinates":102},[103,104],2.3488,48.85341,{"lat":104,"lon":103},[107,110],{"name":108,"role":37,"phone":109,"phoneExt":56,"email":25},"Géraldine LESCAILLE, MD","01 42 17 84 16",{"name":108,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":70,"status":25,"city":112,"state":25,"zip":113,"country":44,"countryCode":45,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"Toulouse","31000",{"type":47,"coordinates":115},[116,117],1.44367,43.60426,{"lat":117,"lon":116},[120,123],{"name":121,"role":37,"phone":122,"phoneExt":56,"email":39},"Franck DELANOE, MD","05 61 77 74 76",{"name":121,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":70,"status":25,"city":112,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":125,"geoPoint":127,"contacts":128},{"type":47,"coordinates":126},[116,117],{"lat":117,"lon":116},[129,133],{"name":130,"role":37,"phone":131,"phoneExt":56,"email":132},"Clément CAMBRONNE, MD","06 78 18 54 78","cambronne.c@chu-toulouse.fr",{"name":130,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":135,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100548285","leukocyte--and-platelet-rich-fibrin-in-the-surgical-treatment-of-medication-related-osteonecrosis-of-the-jaw-100548285",false,"NCT06419010","Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw","Use of Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw: a Randomized Controlled Trial","PeRFOrMand","Inclusion Criteria:\n\n* MRONJ requiring surgical treatment according to AAOMS criteria (stage 2 or 3; failure of first-line treatments; sequestration of a necrotic bone block), the resection of which needs general anesthesia;\n* Affiliates or beneficiaries of a social security scheme.\n* Having given free and informed written consent.\n\nExclusion Criteria:\n\n* Presence of a maxillo-mandibular neoplastic lesion;\n* Presence of several MRONJ lesions;\n* History of cervico-facial radiotherapy;\n* Contraindication to general anesthesia;\n* Reduced life expectancy (estimated at less than 6 months).","ALL","18 Years",{"count":147,"type":148},150,"ESTIMATED","INTERVENTIONAL",[151],"NA","Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious side-effect of antiresorptive therapies used in the management of bone diseases, such as osteoporosis or bone metastases. A surgical management can lead to a resolution of the disease, but with perfectible results. For this purpose, the use of autologous platelet concentrates (APC) can be useful. With this study, researchers aim to demonstrate the efficacy of L-PRF (Leukocyte- and Platelet-Rich Fibrin) as an adjunct to the surgical treatment of MRONJ in terms of wound healing.",[154],"Osteonecrosis of the Jaw",[156,157,158,159,160],"therapeutics","surgical","autologous platelet concentrates","Platelet-Rich Fibrin","PRF","NOT_YET_RECRUITING","2024-05-16",{"date":164,"type":165},"2024-05-17","ACTUAL",{"date":167,"type":148},"2024-05",{"date":169,"type":148},"2027-05",{"name":5,"class":6},7]