[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574300":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":64,"collaborators":26,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":26,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":26,"overallStatus":42,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"The First Affiliated Hospital of Soochow University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sham rTMS Group","SHAM_COMPARATOR","For the sham rTMS group, the coil was placed over the mPFC with the rTMS function disabled, and pre-recorded acoustic artifacts were played to mimic the auditory experience of the rTMS group.",[13],"Device: Sham (No Treatment)",{"label":15,"type":16,"description":17,"interventionNames":18},"rTMS Group","ACTIVE_COMPARATOR","Low-frequency rTMS (1 Hz) was applied to the mPFC using a TMS stimulator at 80% resting motion threshold intensity.",[19],"Device: Repetitive Transcranial Magnetic Stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Repetitive Transcranial Magnetic Stimulation","A figure-of-eight coil is used to apply active low-frequency (1 Hz) rTMS to the corresponding representation area of theprefrontal cortex (mPFC). The treatment is administered for 20 minutes daily for a total of 2 weeks.",[15],null,{"type":22,"name":28,"description":11,"armGroupLabels":29,"otherNames":26},"Sham (No Treatment)",[9],[31],{"name":32,"affiliation":5,"role":33},"Rui Li, Dr.","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"Ruixia Weng, Dr.","CONTACT","15206214921","wengruixia@suda.edu.cn",[41],{"facility":5,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Suzhou","Jiangsu","215006","China","CN",{"type":49,"coordinates":50},"Point",[51,52],120.59538,31.30408,{"lat":52,"lon":51},[55,59,61,62],{"name":56,"role":37,"phone":57,"phoneExt":26,"email":58},"Shuangjie Wu","+8651267972743","sdfyec@163.com",{"name":26,"role":37,"phone":26,"phoneExt":26,"email":60},"lrhcsz@163.com",{"name":32,"role":33,"phone":26,"phoneExt":26,"email":26},{"name":63,"role":33,"phone":26,"phoneExt":26,"email":26},"Ruixia Weng",{"type":65,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100574300","lf-rtms-attenuates-visceral-pain-in-irritable-bowel-syndrome-with-diarrhea-100574300",false,"NCT06757491","Lf-rTMS Attenuates Visceral Pain in Irritable Bowel Syndrome With Diarrhea","Low-frequency Repetitive Transcranial Magnetic Stimulation Attenuates Visceral Pain in Irritable Bowel Syndrome With Diarrhea Via Inhibition of the Medial Prefrontal Cortex","All diagnoses were made by board-certified gastroenterologists. Eligible participants met the following inclusion criteria: (1) age between 18 and 75 years; (2) fulfillment of the Rome IV diagnostic criteria for IBS-D. Exclusion criteria included: (1) presence of inflammatory or other organic gastrointestinal diseases; (2) diagnosed psychiatric disorders; (3) history of anorectal, intestinal, or abdominal surgery; (4) pregnancy or lactation; (5) presence of metallic implants or cardiac pacemakers.","ALL","18 Years","75 Years",{"count":77,"type":78},42,"ESTIMATED","INTERVENTIONAL",[81],"NA","Objectives: To identify a central hub of visceral pain in IBS-D and elucidate the mechanism by which repetitive transcranial magnetic stimulation (rTMS) confers analgesic effects.\n\nMethods: A total of 42 IBS-D patients were recruited and randomly assigned (1:1) to the sham rTMS or the rTMS group. A nested cohort of 21 IBS-D participants who completed baseline fMRI assessments prior to randomization was included. Consistent with the randomization procedure，these individuals were evenly distributed between the two groups. Both participants and outcome assessors remained blinded to treatment allocation throughout the study. All patients completed the two-week intervention and were included in the final analysis.",[23,84,85,86,87],"Chronic Visceral Pain","Functional Magnetic Resonance Imaging","IBS (Irritable Bowel Syndrome)","Clinical Efficacy","2025-11-18",{"date":90,"type":91},"2025-11-21","ACTUAL",{"date":93,"type":91},"2024-08-01",{"date":95,"type":78},"2026-01-25",{"name":5,"class":6},1]