[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100424595":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":25,"responsibleParty":42,"collaborators":25,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":25,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":25,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":25,"overallStatus":64,"whyStopped":25,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":25},{"fullName":5,"class":6},"Women's College Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Local infiltration analgesia","EXPERIMENTAL","Patients in this group will receive LIA intraoperatively, as per institutional standard. The injected solution will be comprised of 100cc Ropiv 2%, + Ketorolac 30 mg + Epinephrine 25 ug.",[13],"Procedure: Local infiltration analgesia",{"label":15,"type":16,"description":17,"interventionNames":18},"Local infiltration analgesia + ACB-iPACK block","ACTIVE_COMPARATOR","Patients in this group will receive LIA intraoperatively, as per institutional standard. The injected solution will be comprised of 100cc Ropiv 2%, + Ketorolac 30 mg + Epinephrine 25 ug.\n\nPatients in this group will also receive preoperative nerve blocks under ultrasound guidance. These will include:\n\n1. Adductor canal block with 0.5% Ropivacaine w\u002Fepi 20 mL\n2. iPack block with 0.25% Ropivacaine w\u002Fepi 10 mL",[13,19],"Procedure: Ultrasound-guided adductor canal block",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Procedure: Local infiltration analgesia performed by surgeons.",[9,15],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Ultrasound-guided adductor canal block","Procedure: Ultrasound-guided adductor canal and iPACK blocks performed by anesthesiologists preoperatively.",[15],[31],"iPACK block",[33],{"name":34,"affiliation":5,"role":35},"Richard Brull, MD","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},"Didem Bozak","CONTACT","416-323-6008","didem.bozak@wchospital.ca",{"type":43,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100424595","lia-vs-lia--acb-ipack-block-for-total-knee-arthroplasty-100424595",false,"NCT04808947","LIA vs. LIA + ACB-iPACK Block for Total Knee Arthroplasty","The Ideal Analgesic Technique for Total Knee Arthroplasty: A Randomized Comparison Between Local Infiltration Analgesia Alone or Combined With Adductor Canal and iPACK Blocks","Inclusion Criteria:\n\n1. ASA classification I-III\n2. BMI \\\u003C 35 kg\u002Fm2\n3. Having elective unilateral total knee arthroplasty\n\nExclusion Criteria:\n\n1. Bilateral knee surgery.\n2. Pre-existing neurological deficit or peripheral neuropathy in the lower the lower limbs\n3. Severe, poorly controlled cardiac conditions, significant arrhythmias, severe valvular heart diseases\n4. Severe, poorly controlled respiratory conditions (severe COPD, severe interstitial lung disease, severe \u002F poorly controlled asthma)\n5. Contraindication to regional anesthesia (e.g. bleeding diathesis, coagulopathy, sepsis, infection at the site of potential needle puncture on the posterior chest)\n6. Patient refusal\n7. Chronic pain disorder\n8. Chronic opioid use (≥30 mg oxycodone \u002F day)\n9. Contraindication (or allergy) to a component of multi-modal analgesia protocol\n10. Allergy to amide local anesthetics used in nerve blocks\n11. Contraindications to spinal anesthesia\n12. Significant psychiatric disorder that would preclude objective study assessment\n13. Pregnancy\n14. Inability to provide informed consent","ALL","18 Years","85 Years",{"count":55,"type":56},60,"ESTIMATED","INTERVENTIONAL",[59],"NA","LIA is the mainstay of postoperative analgesia in patients having knee arthroplasty. The combination of ACB-iPACK blocks has also been proposed as an effective analgesic modality for total knee arthroplasty. However, whether combining these two modalities yields any important incremental analgesic benefit remains unclear. The investigators hypothesized that the addition of ACB and iPACK blocks to LIA will yield clinically important analgesic benefits compared to LIA alone in patients having total knee arthroplasty.",[62,63],"Nerve Block","Neuromuscular Blockade","NOT_YET_RECRUITING","2025-07-14",{"date":67,"type":68},"2025-07-16","ACTUAL",{"date":70,"type":56},"2027-01",{"date":72,"type":56},"2028-12",{"name":5,"class":6}]