[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100465690":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":51,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Marquette University","OTHER",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"Midlife former athletes with a prior knee injury",null,"Inclusion Criteria: Age 40-64 years. Prior participation in a collision, contact, or jumping\u002Fcutting\u002Fpivoting sport (e.g., baseball, basketball, field hockey, football, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the collegiate varsity level for at least 1 season; history of at least 1 prior traumatic knee injury including but not limited to ACL or PCL rupture and\u002For reconstruction, medial and\u002For lateral meniscus tear or surgery, osteochondral defect, and\u002For intra-articular (i.e., tibiofemoral or patellofemoral) fracture.\n\nExclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and\u002For degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement).",{"label":13,"type":10,"description":14,"interventionNames":10},"Midlife former athletes without a prior major lower extremity injury","Inclusion Criteria: Age 40-64 years. Prior participation in a collision, contact, or jumping\u002Fcutting\u002Fpivoting sport (e.g., football, baseball, basketball, field hockey, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the collegiate varsity level for at least 1 season.\n\nExclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and\u002For degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement); prior major lower extremity injury (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation).",{"label":16,"type":10,"description":17,"interventionNames":10},"Midlife controls","Inclusion Criteria: Age 40-64 years.\n\nExclusion Criteria: Prior participation in a collegiate varsity sport or professional sport; neurologic (e.g., stroke, Parkinson's) and\u002For degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement); prior major lower extremity injury (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation).",{"label":19,"type":10,"description":20,"interventionNames":10},"Young adult athletes","Inclusion Criteria: Age 18-25 years. Participation in a collision, contact, or jumping\u002Fcutting\u002Fpivoting sport (e.g., baseball, basketball, field hockey, football, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the varsity collegiate level.\n\nExclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and\u002For degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement).",{"label":22,"type":10,"description":23,"interventionNames":10},"Young adult controls","Inclusion Criteria: Age 18-25 years.\n\nExclusion Criteria: Prior or current participation in any collegiate varsity sport; prior major lower extremity injury or surgery (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation); current participation in competitive sport (e.g., collegiate club sport) more than 3x\u002Fweek; joint replacement in the lower extremity (i.e., knee or hip replacement); current pregnancy; or neurologic condition (e.g., stroke, Parkinson's) and\u002For degenerative condition that impairs function.",[25],{"name":26,"affiliation":5,"role":27},"Jacob J. Capin, DPT, PhD, MS","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","414-288-7865","jacob.capin@marquette.edu",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Milwaukee","Wisconsin","53233","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-87.90647,43.0389,{"lat":45,"lon":44},[48],{"name":49,"role":30,"phone":50,"phoneExt":10,"email":32},"Jacob J. Capin, PhD, DPT, MS","4142887865",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54],{"name":55,"class":56},"National Institutes of Health (NIH)","NIH","100465690","life-after-sport-prior-injury-and-sedentary-behavior-as-mechanisms-of-later-poor-health-100465690",false,"NCT05344001","Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health","Please see cohorts for specific inclusion\u002Fexclusion criteria\n\nInclusion Criteria:\n\n* Age 18-25 years OR age 40-64 years\n* Current or former collegiate varsity athlete OR non-athlete control\n\nExclusion Criteria:\n\n* Neurologic (e.g., stroke, Parkinson's) and\u002For degenerative disease that impairs function\n* Pregnancy\n* Lower extremity joint replacement (e.g., hip or knee replacement)",true,"ALL","18 Years","64 Years",{"count":68,"type":69},450,"ESTIMATED","OBSERVATIONAL","Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.",[73,74,75,76],"Aging","Athletic Injuries","Physical Inactivity","Knee Injuries and Disorders",[78,79,80,81,82,83,84,85],"Sports Medicine","Injury","Athlete","Sport","Physical Activity","Function","Health","Knee","2026-02-23",{"date":88,"type":89},"2026-02-25","ACTUAL",{"date":91,"type":89},"2022-04-18",{"date":93,"type":69},"2027-08",{"name":5,"class":6},1]