[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596179":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":41,"centralContacts":28,"locations":46,"responsibleParty":66,"collaborators":68,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":28,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":97,"overallStatus":49,"whyStopped":28,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"St. Anne's University Hospital Brno, Czech Republic","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Mindfulness Yoga and Time-Restricted Eating Intervention","EXPERIMENTAL","Participants in this arm will take part in a 9-month intervention consisting of yoga-based mindfulness sessions combined with time-restricted eating (16:8 protocol). The yoga program includes physical postures (asanas), breathing techniques, and meditation, aimed at improving physical fitness, stress regulation, and cognitive function. The dietary component promotes a flexitarian diet within an 8-hour daily eating window. Sessions are conducted twice weekly for 90 minutes under certified instructors.",[13,14],"Behavioral: Mindfulness Yoga","Behavioral: Time-Restricted Eating with nutritional counseling promoting a flexitarian dietary pattern",{"label":16,"type":17,"description":18,"interventionNames":19},"Cognitive Training and Stretching Intervention","ACTIVE_COMPARATOR","Participants in this arm will engage in a 9-month intervention including cognitive training exercises and guided stretching. The cognitive program targets multiple domains: verbal and non-verbal memory, executive functions, attention, language, and social cognition. Sessions are delivered twice weekly for 90 minutes by trained therapists. This intervention serves as an active comparator for assessing the effects of yoga and dietary modification on cognitive and biological outcomes.",[20,21],"Behavioral: Cognitive Training","Behavioral: Stretching",[23,29,33,37],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","Mindfulness Yoga","A structured 9-month program integrating physical yoga postures (asanas), breathing techniques, sound, and meditation. Sessions are conducted twice weekly (90 minutes each) and focus on enhancing physical health, stress regulation, and cognitive performance. Delivered by certified instructors.",[9],null,{"type":24,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Time-Restricted Eating with nutritional counseling promoting a flexitarian dietary pattern","Participants follow a 16:8 time-restricted eating schedule (16 hours fasting \u002F 8 hours eating window) for 9 months, with nutritional counseling promoting a flexitarian dietary pattern. The intervention is designed to support metabolic health and reduce risk factors for neurodegeneration.",[9],{"type":24,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"Cognitive Training","A 9-month structured program of twice-weekly cognitive training sessions (90 minutes each), targeting memory, attention, executive function, and social cognition using both paper-based and computer-based tasks. Supervised by trained therapists.",[16],{"type":24,"name":38,"description":39,"armGroupLabels":40,"otherNames":28},"Stretching","A twice-weekly stretching routine performed over 9 months (90-minute sessions), led by physiotherapists. This intervention provides low-intensity physical activity to control for physical engagement across study arms.",[16],[42],{"name":43,"affiliation":44,"role":45},"Kateřina Sheardova, MD. PhD.","The International Clinical Research Center of St. Anne's University Hospital in Brno (FNUSA-ICRC)","PRINCIPAL_INVESTIGATOR",[47],{"facility":48,"status":49,"city":50,"state":28,"zip":51,"country":52,"countryCode":28,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Fnusa\u002F Icrc","RECRUITING","Brno","64400","Czechia",{"type":54,"coordinates":55},"Point",[56,57],16.60796,49.19522,{"lat":57,"lon":56},[60,65],{"name":61,"role":62,"phone":63,"phoneExt":28,"email":64},"Kurečková Kurečková, Ing.","CONTACT","+420 54 318 4086","monika.kureckova@fnusa.cz",{"name":43,"role":45,"phone":28,"phoneExt":28,"email":28},{"type":67,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR",[69],{"name":70,"class":71},"Slovak Academy of Sciences","OTHER_GOV","100596179","lifestyle-for-the-brain-health---time-restricted-eating-and-mindfulness-100596179",false,"NCT07042087","Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness","LIBRA REMIND","Inclusion Criteria:\n\n* Age 60-80 years\n* Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)\n* mini-mental-scale (MMSE) score between 24-30\n* Positive plasma pTau217 biomarker\n* Stable dose of iAChE therapy (if applicable)\n* Ability to participate in a 9-month intervention\n\nExclusion Criteria:\n\n* Stroke or myocardial infarction within the past year\n* Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy)\n* Long-term psychiatric treatment (except well-managed depression)\n* Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy)\n* Severe sensory or motor impairment preventing protocol participation\n* Active cancer treated within the past 5 years\n* Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation)\n* Concurrent participation in another clinical study\n* Unstable iAChE medication regimen\n* Substance or alcohol dependence","ALL","60 Years","80 Years",{"count":83,"type":84},48,"ESTIMATED","INTERVENTIONAL",[87],"NA","The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.",[90,91,92,93,94,95,96],"Alzheimer Disease","Aging","Lifestyle Factors","Cognitive Impairment","Yoga","Time Restricted Eating","Diet Modification",[98,99,34,100,101],"Alzheimer's Disease Prevention","Mindfulness-Based Intervention","Time-Restricted Eating","Dietary consultation","2025-06-19",{"date":104,"type":105},"2025-06-27","ACTUAL",{"date":107,"type":105},"2024-11-01",{"date":109,"type":84},"2026-12",{"name":5,"class":6},1]