[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100483319":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":45,"centralContacts":49,"locations":54,"responsibleParty":71,"collaborators":74,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":35,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":56,"whyStopped":35,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Indiana University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Cognitive Training and Tai Chi- Qi Gong Arm","EXPERIMENTAL","Participants receiving 14 weeks of Cognitive Training (BrainHQ) and Tai Chi- Qi Gong exercise training",[13,14],"Device: Cognitive Training","Behavioral: Tai Chi- Qi Gong",{"label":16,"type":17,"description":18,"interventionNames":19},"Active Control Arm","ACTIVE_COMPARATOR","Participants receiving 14 weeks of Brain Games (BrainHQ) and stretching",[20,21],"Device: Brain Games","Behavioral: Stretching",[23,30,36,41],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DEVICE","Cognitive Training","Participants will be asked to complete approximately 45 minutes of training, 4-5 sessions per week for 14 weeks (corresponding to approximately 40 hours of training total). Training will be completed via BrainHQ, a mobile application that, as used in this study, meets the FDA's definition of a medical device.",[9],[29],"BrainHQ",{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","Tai Chi- Qi Gong","Participants will be asked to complete 14 hours of training total (in 30-minute sessions, 2 days per week for 14 weeks).",[9],null,{"type":24,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"Brain Games","Participants will be asked to complete 40 hours of training total (in 45-minute sessions, 4 to 5 days per week for 14 weeks). Training will be completed via BrainHQ, a mobile application that, as used in this study, meets the FDA's definition of a medical device.",[16],[29],{"type":31,"name":42,"description":43,"armGroupLabels":44,"otherNames":35},"Stretching","Participants will be asked to engage in stretching exercises twice per week, for approximately 20-30 minutes per session. This will total 14 hours over the course of 14 weeks.",[16],[46],{"name":47,"affiliation":5,"role":48},"Dustin B Hammers, PhD","PRINCIPAL_INVESTIGATOR",[50],{"name":47,"role":51,"phone":52,"phoneExt":35,"email":53},"CONTACT","3179638557","hammersd@iu.edu",[55],{"facility":5,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"RECRUITING","Indianapolis","Indiana","46202","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-86.15804,39.76838,{"lat":66,"lon":65},[69,70],{"name":47,"role":51,"phone":52,"phoneExt":35,"email":53},{"name":47,"role":48,"phone":35,"phoneExt":35,"email":35},{"type":48,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Dustin Hammers","Associate Professor",[75,77,80,82],{"name":76,"class":6},"Alzheimer's Association",{"name":78,"class":79},"Tai Chi Foundation","UNKNOWN",{"name":81,"class":6},"Alzheimer's Therapeutic Research Institute",{"name":83,"class":84},"National Institute on Aging (NIA)","NIH","100483319","lifestyle-interventions-for-the-treatment-of-early-onset-alzheimers-disease-study-100483319",false,"NCT05573490","Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study","LITES","Inclusion Criteria:\n\n* Enrolled in the Longitudinal Early-Onset AD Study (LEADS) parent study, and being classified via LEADS consensus criteria as having amyloid-positive Early Onset Alzheimer's Disease\n* Aged 40-64 years at the time of enrollment into LEADS\n* Fluent in English\n* In good general health and absent another neurological disorder\n* Have a knowledgeable informant.\n* Have had a Clinical Dementia Rating scale of 0.5 to 1.0 at the time of enrollment into LEADS\n* Have sufficient vision, hearing, comprehension, and manual dexterity to participate in the testing and training program\n\nExclusion Criteria:\n\n• Have access to the internet (e.g., home, family, public library, etc.) for less than 4 hours per week","ALL","40 Years","75 Years",{"count":96,"type":97},60,"ESTIMATED","INTERVENTIONAL",[100],"NA","The purpose of this study is to generate preliminary data on the benefit of computerized cognitive training and Tai Chi- Qi Gong training in participants with Early-Onset Alzheimer's Disease. It is hypothesized that participants in the experimental training condition will perform better on outcomes related to cognition, functioning, and mood at follow-up compared to participants assigned to the active control condition.",[103],"Alzheimer Disease, Early Onset",[105,106,107,108],"lifestyle intervention","cognitive training","exercise training","cognition","2026-05-05",{"date":111,"type":112},"2026-05-06","ACTUAL",{"date":114,"type":112},"2024-01-11",{"date":116,"type":97},"2028-06",{"name":5,"class":6},1]