[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100340363":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":69,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":10,"studyType":90,"phases":10,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Lifelong Endurance Athletes",null,"i) Athletes who have initiated endurance sports activities at regional, national or international level before the age of 30 years. Sports include triathlon, cycling, distance running (1500 metres and longer) and rowing. ii) Aged 45-70 years. iii) Involved in competition and high-level training: more than 10 hours per week for cyclists and triathletes or more than 6 hours per week for runners and rowers. Subjects will be excluded if: i) they have a history of smoking (\\> 5 pack years) or diabetes, ii) had been diagnosed with a cardiopulmonary disorder prior to inclusion.",{"label":13,"type":10,"description":14,"interventionNames":10},"Late-onset Endurance Athletes","i) Athletes who have initiated endurance sports activities at regional, national or international level after the age of 30 years. Sports include triathlon, cycling, distance running (1500 metres and longer) and rowing. ii) Aged 45-70 years. iii) Involved in competition and high-level training: more than 10 hours per week for cyclists and triathletes or more than 6 hours per week for runners and rowers. Subjects will be excluded if: i) they have a history of smoking (\\> 5 pack years) or diabetes, ii) they have a history of smoking (\\> 5 pack years) or diabetes, ii) had been diagnosed with a cardiopulmonary disorder prior to inclusion.",{"label":16,"type":10,"description":17,"interventionNames":10},"Healthy Non-athletes","Healthy non-athletes will be recruited from subjects seen in the outpatient clinic for a work-related medical check-up, from university alumni and from multisports organisations. Subjects will be excluded if they: i) had been involved in regular sports practice more than \\>3 hours \u002F week, ii) have a history of smoking (\\> 5 pack years) or diabetes, or iii) had been diagnosed with a cardiopulmonary disorder prior to inclusion. Participation in regular sports with a low dynamic component (e.g. billiards, darts or bowling) \\>3 hours \u002Fweek is allowed.",[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Guido Claessen, MD, PhD","CONTACT","+3216343397","guido.claessen@kuleuven.be",[25,43,57],{"facility":26,"status":27,"city":28,"state":10,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"University Hospital, Antwerpen","RECRUITING","Edegem","2650","Belgium","BE",{"type":33,"coordinates":34},"Point",[35,36],4.44504,51.15662,{"lat":36,"lon":35},[39],{"name":40,"role":21,"phone":41,"phoneExt":10,"email":42},"Hein Heidbuchel, MD, PhD","+3238214693","hein.heidbuchel@uantwerpen.be",{"facility":44,"status":27,"city":45,"state":10,"zip":46,"country":30,"countryCode":31,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Jessa Hospital","Hasselt","3500",{"type":33,"coordinates":48},[49,50],5.33781,50.93106,{"lat":50,"lon":49},[53],{"name":54,"role":21,"phone":55,"phoneExt":10,"email":56},"Lieven Herbots, MD, PhD","+3211373565","lieven.herbots@jessazh.be",{"facility":58,"status":27,"city":59,"state":10,"zip":60,"country":30,"countryCode":31,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"UZLeuven","Leuven","3000",{"type":33,"coordinates":62},[63,64],4.70093,50.87959,{"lat":64,"lon":63},[67],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":68},"guido.claessen@uzleuven.be",{"type":70,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[72,74],{"name":73,"class":6},"University Hospital, Antwerp",{"name":44,"class":6},"100340363","lifetime-endurance-exercise-to-prevent-coronary-artery-disease-100340363",false,"NCT03711539","Lifetime Endurance Exercise to Prevent Coronary Artery Disease","Lifetime Endurance Exercise to Prevent Coronary Artery Disease. A Comparison With Late-onset Endurance Training and a Sedentary Lifestyle","MASTER@HEART","Inclusion Criteria:\n\n* Lifelong endurance athletes:\n\n  * Initiation of endurance sports before the age of 30 years\n  * Activities at regional, national or international level\n  * Sports: triathlon, cycling, distance running (1500 metres and longer) and rowing\n  * Aged 45-70 years\n  * Involved in competition and high-level training:\n\n    * more than 10 hours per week for cyclists and triathletes\n    * more than 6 hours per week for runners and rowers.\n* Late-onset endurance athletes:\n\n  * Initiation of endurance sports after the age of 30 years and at least 6 months ago\n  * Activities at regional, national or international level\n  * Sports: triathlon, cycling, distance running (1500 metres and longer) and rowing\n  * Aged 45-70 years\n  * Involved in competition and high-level training:\n\n    * more than 10 hours per week for cyclists and triathletes\n    * more than 6 hours per week for runners and rowers.\n* Healthy non-athletes\n\n  * subjects seen in the outpatient clinic for a work-related medical check-up\n  * university alumni\n  * subjects from multisports organisations\n  * history of regular sports practice \\\u003C3 hours \u002Fweek\n  * participation in regular sports with a low dynamic component (e.g. billiards, darts or bowling) \\>3 hours \u002Fweek is allowed\n\nExclusion Criteria:\n\n* history of smoking (\\> 5 pack years)\n* history of diabetes\n* diagnosis of cardiopulmonary disorder prior to inclusion\n* medical treatment for arterial hypertension or hypercholesterolemia",true,"MALE","45 Years","70 Years",{"count":88,"type":89},1800,"ESTIMATED","OBSERVATIONAL","The primary objective of the Master@Heart Trial is to investigate whether lifelong endurance exercise reduces the incidence of non-calcified plaques (both mixed and soft plaques) as compared to late-onset endurance exercise and a non-athletic lifestyle.",[93,94,95],"Coronary Artery Disease","Physical Activity","Lifestyle",[97,93,98,99,100],"Endurance Exercise","Atrial Fibrillation","Myocardial Fibrosis","Coronary CT","2024-07-02",{"date":103,"type":104},"2024-07-03","ACTUAL",{"date":106,"type":104},"2018-10-18",{"date":108,"type":89},"2025-10-01",{"name":5,"class":6},3]