[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565745":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":61,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mixture of liposome bupivacaine and bupivacaine hydrochloride","EXPERIMENTAL","The same anesthesiologist with experience in regional block was used for ultrasound guided bilateral transverse thoracic muscle plane block (T4-5 interstital space, paracentral transverse axis position). According to the literature, in this study, 1.33% bupivacaine liposome 10 mL + 0.5% bupivacaine hydrochloride 10 ml was used.",[13],"Procedure: Transverse thoracic muscle plane block (TTMPB) using liposomal bupivacaine and bupivacaine mixture",{"label":15,"type":16,"description":17,"interventionNames":18},"Bupivacaine hydrochloride alone","ACTIVE_COMPARATOR","The same anesthesiologist with experience in regional block was used for ultrasound guided bilateral transverse thoracic muscle plane block (T4-5 interstital space, paracentral transverse axis position). According to the literature, in this study, 0.5% bupivacaine 20ml was used.",[19],"Procedure: Transverse thoracic muscle plane block (TTMPB) using bupivacaine hydrochloride",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Transverse thoracic muscle plane block (TTMPB) using liposomal bupivacaine and bupivacaine mixture","Liposomal bupivacaine and bupivacaine mixture were used for transverse thoracic muscle plane block (TTMPB) in experimental group.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Transverse thoracic muscle plane block (TTMPB) using bupivacaine hydrochloride","Bupivacaine hydrochloride was used for transverse thoracic muscle plane block (TTMPB) in active control group.",[15],[32],{"name":33,"affiliation":5,"role":34},"Mei Wei, M.D.","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Liu Tianzhu, M.D.","CONTACT","13098866448","liutzh@126.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Tianzhu Liu","RECRUITING","Wuhan","Hubei","430000","China","CN",{"type":51,"coordinates":52},"Point",[53,54],114.26667,30.58333,{"lat":54,"lon":53},[57,59],{"name":58,"role":38,"phone":39,"phoneExt":26,"email":40},"Tianzhu, M.D.",{"name":60,"role":38,"phone":39,"phoneExt":26,"email":40},"Tianzhu Liu, M.D.",{"type":62,"investigatorFullName":43,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100565745","liposomal-bupivacaine-and-bupivacaine-for-ttmpb-in-median-sternotomy-100565745",false,"NCT06646172","Liposomal Bupivacaine and Bupivacaine for TTMPB in Median Sternotomy","Liposomal Bupivacaine and Bupivacaine Alone Transverse Thoracic Muscle Plane Blocks in Median Sternotomy: a Prospective, Single-blind, Randomized Controlled Study","Inclusion Criteria:\n\n* Patients aged 18-90 years;\n* ASA Class I \\~ III;\n* Patients undergoing elective median sternotomy.\n\nExclusion Criteria:\n\n* Emergency surgery;\n* Re-operation;\n* Coagulation dysfunction;\n* Preoperative left ventricular function was poor (ejection fraction \\\u003C35%);\n* Systemic infection or injection site infection;\n* Neuromuscular diseases;\n* Mental illness;\n* Dependence on psychotropic drugs;\n* Allergic to bupivacaine liposomes and bupivacaine;\n* Patients have participated in previous trials or have been determined by a surgeon or anesthesiologist to be unsuitable for randomization;\n* Failure to obtain written informed consent from the patient or his\u002Fher representative","ALL","18 Years","90 Years",{"count":75,"type":76},38,"ESTIMATED","INTERVENTIONAL",[79],"NA","In light of the ongoing controversy surrounding the efficacy of bupivacaine liposomes, our study was designed to investigate, for the first time, the differential postoperative analgesic effects between bupivacaine liposomes combined with bupivacaine hydrochloride and bupivacaine hydrochloride alone in transverse thoracic muscle plane block treatment. The aim is to provide evidence-based medical guidance for drug selection in regional block local anesthesia.",[82],"Median Sternotomy","2024-10-24",{"date":85,"type":86},"2024-10-28","ACTUAL",{"date":83,"type":86},{"date":89,"type":76},"2026-10-12",{"name":5,"class":6},1]