[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600885":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":12,"locations":23,"responsibleParty":66,"collaborators":7,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":7,"enrollmentInfo":78,"targetDuration":81,"studyType":82,"phases":7,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":88,"whyStopped":7,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University Hospital, Rouen","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Search for activating somatic genetic mutations","This research aims to evaluate the genetic mutations identified by liquid biopsies on the drainage vein of AVMs, and the prevalence of each mutation.\n\nThese liquid biopsies will be performed during the embolisation procedure by sampling the drainage vein of the malformation and peripheral venous blood (no additional procedures compared to standard care).",[13,19],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},"Julien JB BUREL, Doctor","CONTACT","02 32 88 88 50","+33","Julien.Burel@chu-rouen.fr",{"name":20,"role":15,"phone":21,"phoneExt":17,"email":22},"Vincent VF FERRANTI, ARC","02 32 88 82 65","Vincent.Ferranti@chu-rouen.fr",[24,41,55],{"facility":25,"status":7,"city":26,"state":7,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"University Hospital of Caen","Caen","14033","France","FR",{"type":31,"coordinates":32},"Point",[33,34],-0.35912,49.18585,{"lat":34,"lon":33},[37],{"name":38,"role":15,"phone":39,"phoneExt":17,"email":40},"Charlotte CB BARBIER, Doctor","02 31 06 46 97","barbier-ch@chu-caen.fr",{"facility":42,"status":7,"city":43,"state":7,"zip":44,"country":28,"countryCode":29,"cosmosGeoPoint":45,"geoPoint":49,"contacts":50},"Hôpital la Pitié-Salpêtrière","Paris","75013",{"type":31,"coordinates":46},[47,48],2.3488,48.85341,{"lat":48,"lon":47},[51],{"name":52,"role":15,"phone":53,"phoneExt":17,"email":54},"Frederic FC CLARENCON, Professor","01 42 16 55 45","frederic.clarencon@aphp.fr",{"facility":56,"status":7,"city":57,"state":7,"zip":58,"country":28,"countryCode":29,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"University Hospital of Rouen","Rouen","76031",{"type":31,"coordinates":60},[61,62],1.09932,49.44313,{"lat":62,"lon":61},[65],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},{"type":67,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100600885","liquid-biopsies-for-detecting-somatic-mutations-in-sporadic-cerebral-arteriovenous-malformations-100600885",false,"NCT07103304","Liquid Biopsies for Detecting Somatic Mutations in Sporadic Cerebral Arteriovenous Malformations.","Liquid Biopsies for Detecting Somatic Mutations in Sporadic Cerebral Arteriovenous Malformations. Contribution of Sampling From the Drainage Vein of the Malformation.","BioMAV2","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Treated for cAVM\n* Indication for embolisation treatment decided upon during a multidisciplinary team meeting (MDT)\n* Venous embolisation, with or without arterial embolisation\n* Patients informed about the study and willing to participate\n\nExclusion Criteria:\n\n* Extra-cerebral arteriovenous malformations\n* Under legal protection measures (guardianship\u002Fcuratorship, etc.)\n* Pregnancy\n* Not eligible for intravenous treatment","ALL","18 Years",{"count":79,"type":80},16,"ESTIMATED","3 Months","OBSERVATIONAL","Cerebral arteriovenous malformations (CAVMs) are abnormal vessels located on the surface of the brain or within the cerebral parenchyma, causing abnormal communication between the arterial and venous networks, without the interposition of the capillary bed. The main risk associated with these malformations is rupture, which causes intracranial bleeding and can lead to serious sequelae or even death. CAVMs (except those of clearly identified genetic origin \\[\\\u003C 5%\\], such as mutations associated with Rendu-Osler disease) have long been considered to be of non-genetic origin.\n\nHowever, somatic genetic mutations that activate the RAS\u002FRAF\u002FMEK\u002FERK (MAPK) signalling pathway have recently been identified in surgical specimens of cAVMs. Furthermore, targeted inhibition of this pathway is effective in treating these malformations in animals and appears to be effective in extracranial arteriovenous malformations, particularly superficial ones.",[85],"Cerebral Arteriovenous Malformations",[87,10],"embolisation","NOT_YET_RECRUITING","2025-09-01",{"date":91,"type":92},"2025-09-08","ACTUAL",{"date":89,"type":80},{"date":95,"type":80},"2028-04-01",{"name":5,"class":6},3]