[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598729":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":42,"locations":52,"responsibleParty":70,"collaborators":26,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":26,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":55,"whyStopped":26,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Horus University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A","EXPERIMENTAL","16 patients have anterior disc displacement with or without reduction will be treated with injection of liquid phase concentrated growth factor",[13],"Procedure: Liquid Phase Concentrated Growth Factor",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B","ACTIVE_COMPARATOR","16 patients have anterior disc displacement with or without reduction will be treated with conventional arthrocentesis",[19],"Procedure: Conventional arthrocentesis",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Liquid Phase Concentrated Growth Factor","16 patients with anterior disc displacement with or without reduction randomly allocated to be treated with injection of liquid phase concentrated growth factor",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional arthrocentesis","16 patients with anterior disc displacement with or without reduction randomly allocated to be treated with conventional arthrocentesis",[15],[32,36,40],{"name":33,"affiliation":34,"role":35},"Mohamed Ali Habib, Teaching Assistant","Horus University in Egypt - Faculty of dentistry","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":38,"role":39},"Eman AbdElsalam Yousef, Ass. prof","Horus University in Egypt- Faculty of dentistry","STUDY_DIRECTOR",{"name":41,"affiliation":34,"role":39},"Ahmed Khalil, lecturer",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":26,"email":47},"Mohamed Ali Habib, Teaching assistant","CONTACT","+2001069505336","mbasiouny@horus.edu.eg",{"name":49,"role":45,"phone":50,"phoneExt":26,"email":51},"Eman AbdElsalam Yousef, Associate professor","+20 15 56767533","eabdelsalam@horus.edu.eg",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Faculty of Dentistry- Horus University in Egypt","RECRUITING","Damietta","New Damietta","34518","Egypt","EG",{"type":62,"coordinates":63},"Point",[64,65],31.81332,31.41648,{"lat":65,"lon":64},[68],{"name":33,"role":45,"phone":69,"phoneExt":26,"email":47},"+201069505336",{"type":35,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Mohamed Ali Habib","Teaching assistant","100598729","liquid-phase-concentrated-growth-factor-versus-conventional-arthrocentesis-in-temporomandibular-disc-displacement-100598729",false,"NCT07075276","Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement","Injection of Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Management of Temporomandibular Disc Displacement: A Randomized Controlled Clinical Trial","LPCGF in TMDs","Inclusion Criteria:\n\n* 1\\. Adults aged 18-45 years. 2. Patients scored as (ASA I).9 3. Presence of complete or nearly complete set of natural dentition with Angle class I occlusion. 4. Diagnosed with unilateral involvement of disc displacement, according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC\u002FTMD).10 5. Symptoms include one or more of the following: pain, joint sounds, and limited mandibular movement (Maximum Mouth Opening\\\u003C 40mm) 6. No prior surgical intervention for TMD. 7. Patient's willingness to participate and follow the study protocol.\n\nExclusion Criteria:\n\n* 1\\. TMJ pathology related to mechanical deformities 2. Psychiatric problems or presence of systemic diseases that may affect healing (e.g., uncontrolled diabetes, autoimmune disorders, hematologic or neurologic disorders, inflammatory or connective tissue disorders as well as rheumatological or previous infectious diseases, head and neck cancer). 3. Patient unwilling or has contraindication to MRI 4. Previous injections or surgical interventions of the TMJ. 5. Concurrent use of anticoagulants or anti-inflammatory medications within the last 30 days. 6. Pregnant or breastfeeding women. 7. History of trauma or infection in the TMJ region. 8. Allergy to local anesthetics or other components used in the study. 9. Patients diagnosed with (Disc Displacement with reduction with no pain or limited mandibular movements).",true,"ALL","18 Years","45 Years",{"count":86,"type":87},32,"ESTIMATED","INTERVENTIONAL",[90],"NA","This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial. By comparing LPCGF therapy with conventional arthrocentesis, this research looks to provide robust evidence on the efficacy, safety, and potential role of (LPCGF) as an alternative therapeutic choice for IDD.",[93,94,95],"Temporomandibular Disorders (TMD)","Internal Derangement of the Tempromandibular Joint","Anterior Disc Displacement",[97,98,99,100,101],"Temporomandibular disorder","Concentrated growth factor","Anterior disc displacement with reduction","Anterior disc displacement without reduction","Arthrocentesis","2026-03-08",{"date":104,"type":105},"2026-03-11","ACTUAL",{"date":107,"type":105},"2025-10-01",{"date":109,"type":87},"2026-06-01",{"name":5,"class":6},1]