[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100416216":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":28,"centralContacts":29,"locations":39,"responsibleParty":110,"collaborators":114,"id":118,"slug":119,"hasResults":120,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":28,"eligibilityCriteria":124,"healthyVolunteers":120,"sex":125,"minAge":126,"maxAge":28,"enrollmentInfo":127,"targetDuration":28,"studyType":130,"phases":131,"briefSummary":133,"conditions":134,"keywords":138,"overallStatus":42,"whyStopped":28,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":151},{"fullName":5,"class":6},"University of Maryland, Baltimore","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"LITT with Hypofractionated RT","EXPERIMENTAL","Laser interstitial thermal therapy (LITT) followed by hypo-fractionated radiation therapy, 25Gy\u002F10 fractions.",[13,14],"Procedure: LITT","Radiation: Hypofractionated Radiation Therapy",[16,23],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"PROCEDURE","LITT","This procedure is done under MRI guidance and employs low-powered thermal energy to achieve tumor ablation through coagulation.",[9],[22],"Laser Interstitial thermal therapy",{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"RADIATION","Hypofractionated Radiation Therapy","Treatments will be delivered once daily on consecutive treatment days (typically 5 fractions per week). Radiation therapy simulation is to be performed within 10 days of the LITT procedure.",[9],null,[30,35],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},"Mark Mishra, MD","CONTACT","410-328-6080","mmishra@umm.edu",{"name":36,"role":32,"phone":37,"phoneExt":28,"email":38},"Caitlin Eggleston, BS","410-328-7586","caitlineggleston@umm.edu",[40,58,69,83,96],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Maryland Proton Treatment Center","RECRUITING","Baltimore","Maryland","21201","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-76.61219,39.29038,{"lat":52,"lon":51},[55,57],{"name":31,"role":32,"phone":56,"phoneExt":28,"email":34},"4103286080",{"name":36,"role":32,"phone":37,"phoneExt":28,"email":38},{"facility":59,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},"University of Maryland Greenebaum Cancer Center",{"type":49,"coordinates":61},[51,52],{"lat":52,"lon":51},[64,65,66],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},{"name":36,"role":32,"phone":33,"phoneExt":28,"email":38},{"name":67,"role":68,"phone":28,"phoneExt":28,"email":28},"Graeme Woodworth, MD","SUB_INVESTIGATOR",{"facility":70,"status":42,"city":71,"state":44,"zip":72,"country":46,"countryCode":47,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"UCH Kaufman Cancer Center","Bel Air","21014",{"type":49,"coordinates":74},[75,76],-76.34829,39.53594,{"lat":76,"lon":75},[79,80],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":28},{"name":81,"role":32,"phone":28,"phoneExt":28,"email":82},"Linda Romar","lromar@umm.edu",{"facility":84,"status":42,"city":85,"state":44,"zip":86,"country":46,"countryCode":47,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Central Maryland Radiation Oncology","Columbia","21044",{"type":49,"coordinates":88},[89,90],-76.83942,39.24038,{"lat":90,"lon":89},[93,94],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":28},{"name":95,"role":32,"phone":28,"phoneExt":28,"email":38},"Caitlin Eggleston",{"facility":97,"status":42,"city":98,"state":44,"zip":99,"country":46,"countryCode":47,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Baltimore Washington Medical Center","Glen Burnie","21061",{"type":49,"coordinates":101},[102,103],-76.62469,39.16261,{"lat":103,"lon":102},[106,107],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},{"name":108,"role":32,"phone":28,"phoneExt":28,"email":109},"Pilar Strycula","P.Strycula@umm.edu",{"type":111,"investigatorFullName":112,"investigatorTitle":113,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","Department of Radiation Oncology","Principal Investigator",[115],{"name":116,"class":117},"Keep Punching Foundation","UNKNOWN","100416216","litt-followed-by-hypofractionated-rt-for-newly-diagnosed-gliomas-gcc-20138-100416216",false,"NCT04699773","LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)","Laser Interstitial Thermal Therapy Followed By Hypofractionated Radiation Therapy For Treatment Of Newly Diagnosed High-Grade Gliomas","Inclusion Criteria:\n\n1. Patients with radiographic evidence of suggestive of a primary high-grade glioma\n2. Brain MRI with contrast demonstrates an enhancing mass within 60 days prior to registration. Patient must be deemed a candidate for LITT from MRI by Neurosurgery in order to be eligible.\n3. History and physical including neurological exam within 30 days prior to registration\n4. Karnofsky performance status ≥50% within 30 days prior to registration\n5. Age ≥ 18 years old\n6. Patients must have signed an approved informed consent\n7. Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.\n8. Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.\n\nExclusion Criteria:\n\n1. Patients that are not surgical candidates for stereotactic biopsy or laser ablation\n2. Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following:\n\n   * History or presence of serious uncontrolled ventricular or significant arrhythmias.\n   * Any of the following within 6 months prior to registration: myocardial infarction, severe\u002Funstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism\n3. Infratentorial tumor or evidence of leptomeningeal spread\n4. Inability to undergo a MRI\n5. Pregnant or breast-feeding women","ALL","18 Years",{"count":128,"type":129},32,"ESTIMATED","INTERVENTIONAL",[132],"NA","The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.",[135,136,137],"Glioma","Glioblastoma","Brain Tumor",[139,137,140,141,135],"Laser Interstitial Thermal Therapy","Radiotherapy","Proton Therapy","2026-05-05",{"date":144,"type":145},"2026-05-06","ACTUAL",{"date":147,"type":145},"2021-02-20",{"date":149,"type":129},"2027-12",{"name":5,"class":6},5]